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Lyme Disease Working Group
Lyme Borreliosis, more commonly known as Lyme disease, is the most frequently reported vector-borne illness in the United States.
Lyme disease affects individuals of all ages and is caused by the bacterium Borrelia burgdorferi, transmitted through the bite of a tick. The disease is thought to be characterized by a signature “bulls-eye” rash around the bite-site in the early localized stage of Lyme disease, although this rash is not always present. Symptoms of headache, fever and fatigue can present soon after infection. Lyme disease can cause worsening symptoms over time during early and later disseminated stages. It is thought to be responsible for devastating effects in the health of humans including serious disease and sequelae in the brain, heart muscle and joint tissue. Meningitis, cranial neuritis, radiculoneuritis, peripheral neuritis, carditis, heart block, migratory musculoskeletal pain, intermittent or chronic arthritis, polyneuropathy, and chronic encephalopathy affecting memory, mood, or sleep have been associated with B. burgdorferi infection.
Consequently, Lyme disease and Lyme-like diseases are often debilitating, but little is known about how this infection can trigger symptoms that in some cases do not resolve even after a course of high dose antibiotics. Developing new methods to diagnose, monitor and treat Lyme disease and other tick-borne diseases (TBD) will allow us to reduce and hopefully eliminate the burden and cost of this prevalent chronic disability.
Fortunately, recently available research findings (e.g., biofilms, spirochete replication and adaptation, metabolic vulnerabilities) are opening a gateway to more enlightened medical understanding. This growing body of evidence offers fresh pathways for innovative research that can help to transcend the scientific debate, and point to better means of TBD diagnosis, treatment and prevention. In the long run, such research may offer a transformative lens through which to view other complex human ailments.
Lyme Disease Working Group
Despite the high occurrence of disease, and disagreements within the medical community about Lyme disease and other tick-borne diseases, evidence from research on this illness is in its infancy. A group of scientists and physicians have formed a Lyme Disease Working Group – a Stanford-based, integrated, interdisciplinary initiative to address the global ravages of Lyme disease. With the encouragement of a number of Lyme Disease organizations, we have initiated philanthropically focused efforts to support current research and clinical projects, and catalyze new work.
Our Lyme Disease Working Group is interested in developing more accurate diagnostic tests, improving medical understanding of the course of illness, evaluating the effectiveness of innovative therapies, expanding clinical services, and building greater knowledge and awareness of how to prevent illness. Participating colleagues represent biochemistry, biomedical informatics, biomaterials and advanced drug delivery, cardiovascular medicine, community ecology of wildlife disease, genetics, infectious disease, pediatrics, pain management, microbiology/immunology, neurology, psychiatry and behavioral sciences, and rheumatology/immunology. Basing this effort at Stanford University will build upon the advantages of working within an institution that strongly supports academic freedom while also encouraging interdisciplinary collaboration. This extraordinary interdisciplinary group also values collaboration with other academic institutions and a number of collaborations are underway.
Such a model is optimal in this context for its potential to produce major breakthroughs in knowledge and improve medical practice—perhaps even more so in the context of Lyme disease where bringing together diverse views is greatly needed to advance the science and inform practice.
Greater funding will enable us to accelerate the work of a coordinated interdisciplinary Lyme disease program that focuses on cutting edge research, and to use the new knowledge that ensues to set the standards for development of evidence-based clinical practices, inform public policy,and improve education accordingly.
- – Taking A Stand 4 Lyme
Taking A Stand 4 Lyme: Scientists Tackle the Lyme Disease Epidemic
In Stand4Lyme Foundation's new video, Stanford Lyme Disease Working Group members speak about the serious consequences of Lyme and tick-borne diseases to help educate stakeholders from a scientific perspective and garner increased government support and funding.
- – Tick and Mosquito Infections Spreading Rapidly, C.D.C. Finds
Tick and Mosquito Infections Spreading Rapidly, C.D.C. Finds
Rates of Lyme, Zika and exotic new diseases are soaring. Federal officials blame hotter weather, jet travel, forested suburbs and slow vaccine development.
- – KRON4
VIDEO: May is Lyme Disease Awareness Month
KRON Channel 4 covers Lyme Disease Awareness Month
- – News Center
New compounds have potential to combat Lyme disease
Researchers here have discovered drugs with the potential to eliminate the Lyme disease-causing bacteria Borrelia burgdorferi at the onset of infection. Jayakumar Rajadas, director of the medical school’s Biomaterials and Advanced Drug Delivery Laboratory is senior author. The lead author is postdoctoral scholar Venkata Raveendra Pothineni.
Seed Grant Projects
2017 Research on Lyme Disease: Funded Project Titles
- Biomechanical alterations of endothelial cells infected with Borrelia burgdorferi
- Novel microneedle patch development for detection of Borrelia burgdorferi
- Stem Cell Model of Lyme Carditis
2018 Research on Lyme Disease: Funded Project Titles
- Proteome-wide Profiling of Borrelia Burgdorferi to Identify Temperature Sensitive Modulators of Infection and Persistence
- Evaluating GABA depletion as the major cause for symptomatic pain, fatigue, and brain fog in post-treatment Lyme disease syndrome (PTLDS) using disulfiram treatment
- Functional MRI and sensory evaluation of central mechanisms of chronic pain associated with Lyme disease
- Investigating the Sexual Transmission and Developmental Consequences of Borrelia burgdorferi
2020 Research on Lyme Disease: Funded Project Titles
- Impact of habitat fragmentation on Lyme disease entomological hazard and human Lyme disease incidence in California landscapes
- Teleyoga for Lyme Disease
- Correlation of Lyme Incidence with Meteorological Alterations Throughout the Eastern United States, 2003 – 2018 (CLIMATE)