Lyme Disease Working Group

On August 18, 2013, the Centers for Disease Control and Prevention (CDC) announced its
ten-fold increased prevalence estimate of Lyme disease, from 30,000 new infections per year in the U.S. to a preliminary new estimate of 300,000.

Seed Grant Projects

2018 Research on Lyme Disease

Proteome-wide Profiling of Borrelia Burgdorferi to Identify Temperature Sensitive Modulators of Infection and Persistence

PI: Balyn Wood Zaro, PhD
Postdoctoral Scholar in the Stem Cell Bio Regenerative Department

Evaluating GABA depletion as the major cause for symptomatic pain, fatigue, and brain fog in post-treatment Lyme disease syndrome (PTLDS) using disulfiram treatment

PI: Lawrence Steinman, MD
Professor of Neurology and Neurological Sciences in the Neurology Department
The investigative team includes John Wesson Ashford, a Clinical Professor (affiliated) in the Department of Psychiatry and Behavioral Sciences and Jayakumar Rajadas, Director, BioADD and Assistant Director of CV Pharmacology in the Diomaterials and Advanced Drug Delivery laboratory.

Functional MRI and sensory evaluation of central mechanisms of chronic pain associated with Lyme disease

PI: Danielle D. DeSouza, MSc, PhD
Instructor in the Department of Neurology and Neurological Sciences

Investigating the Sexual Transmission and Developmental Consequences of Borrelia burgdorferi

PI: Victoria Mascetti PhD
Postdoctoral Scholar in the Stem Cell Bio Regenerative Department
The investigative team includes Michal Tal Ph.D., a Postdoctoral Scholar in the Stem Cell Bio Regenerative Department and Maia Shoham, Life Science Research Professional at the Stem Cell Bio Regenerative Med Institute.

2017 Research on Lyme Disease

Biomechanical alterations of endothelial cells infected with Borrelia burgdorferi

PI: Effie E. Bastounis PhD
Postdoctoral Research Fellow in Biochemistry

Novel microneedle patch development for detection of Borrelia burgdorferi

PI: Michal Caspi Tal PhD
Postdoctoral Fellow in Stem Cell and Regenerative Medicine

Stem Cell Model of Lyme Carditis

PI: Nazish Sayed MD, PhD
Instructor in the Cardiovascular Institute
The investigative team includes Joseph C. Wu, MD, PhD., is Director of the Stanford Cardiovascular Institute, Jayakumar Rajadas, Director, BioADD and Assistant Director of CV Pharmacology in the Diomaterials and Advanced Drug Delivery laboratory and Edward S Mocarski, PhD., consultant and professor at Emory Vaccine Center, Emory University.

Background

Handmade statues made by Sherry Cagan thanking Dr. Laura Roberts and Dr. Mark Davis as "champions" in the Stand4Lyme Foundation

Lyme Borreliosis, more commonly known as Lyme disease, is the most frequently reported vector-borne illness in the United States.

Lyme disease affects individuals of all ages and is caused by the bacterium Borrelia burgdorferi, transmitted through the bite of a tick. The disease is thought to be characterized by a signature “bulls-eye” rash around the bite-site in the early localized stage of Lyme disease, although this rash is not always present. Symptoms of headache, fever and fatigue can present soon after infection. Lyme disease can cause worsening symptoms over time during early and later disseminated stages. It is thought to be responsible for devastating effects in the health of humans including serious disease and sequelae in the brain, heart muscle and joint tissue. Meningitis, cranial neuritis, radiculoneuritis, peripheral neuritis, carditis, heart block, migratory musculoskeletal pain, intermittent or chronic arthritis, polyneuropathy, and chronic encephalopathy affecting memory, mood, or sleep have been associated with B. burgdorferi infection.

Consequently, Lyme disease and Lyme-like diseases are often debilitating, but little is known about how this infection can trigger symptoms that in some cases do not resolve even after a course of high dose antibiotics. Developing new methods to diagnose, monitor and treat Lyme disease and other tick-borne diseases (TBD) will allow us to reduce and hopefully eliminate the burden and cost of this prevalent chronic disability.

Fortunately, recently available research findings (e.g., biofilms, spirochete replication and adaptation, metabolic vulnerabilities) are opening a gateway to more enlightened medical understanding. This growing body of evidence offers fresh pathways for innovative research that can help to transcend the scientific debate, and point to better means of TBD diagnosis, treatment and prevention. In the long run, such research may offer a transformative lens through which to view other complex human ailments.

Despite the high occurrence of disease, and disagreements within the medical community about Lyme disease and other tick-borne diseases, evidence from research on this illness is in its infancy. A group of scientists and physicians have formed a Lyme Disease Working Group – a Stanford-based, integrated, interdisciplinary initiative to address the global ravages of Lyme disease. With the encouragement of a number of Lyme Disease organizations, we have initiated philanthropically focused efforts to support current research and clinical projects, and catalyze new work.

Our Lyme Disease Working Group is interested in developing more accurate diagnostic tests, improving medical understanding of the course of illness, evaluating the effectiveness of innovative therapies, expanding clinical services, and building greater knowledge and awareness of how to prevent illness. Participating colleagues represent biochemistry, biomedical informatics, biomaterials and advanced drug delivery, cardiovascular medicine, community ecology of wildlife disease, genetics, infectious disease, pediatrics, pain management, microbiology/immunology, neurology, psychiatry and behavioral sciences, and rheumatology/immunology. Basing this effort at Stanford University will build upon the advantages of working within an institution that strongly supports academic freedom while also encouraging interdisciplinary collaboration.  This extraordinary interdisciplinary group  also values collaboration with other academic institutions and a number of collaborations are underway.

Such a model is optimal in this context for its potential to produce major breakthroughs in knowledge and improve medical practice—perhaps even more so in the context of Lyme disease where bringing together diverse views is greatly needed to advance the science and inform practice.

Greater funding will enable us to accelerate the work of a coordinated interdisciplinary Lyme disease program that focuses on cutting edge research, and to use the new knowledge that ensues to set the standards for development of evidence-based clinical practices, inform public policy,and improve education accordingly.

Working Group Members

John Barry, M.D.

Professor of Psychiatry and Behavioral Sciences and, 
by courtesy, of Neurology

Mark Davis, Ph.D.

The Burt and Marion Avery Family Professor of Immunology 
Director, Stanford Institute for Immunity, Transplantation and Infection

Ronald W. Davis, Ph.D.

Professor of Biochemistry and of Genetics

Jennifer Frankovich, MD MS

Clinical Associate Professor of Pediatric Rheumatology
Co-Director of the PANS Program:  Pediatric Acute Onset Neuropsychiatric Syndrome

Cheryl Gore-Felton, Ph.D.

Professor of Psychiatry and Behavioral Sciences and Associate Chair
Associate Dean, School of Medicine

Rohit Gupta

Executive Director, CTRU
Director, Spectrum Biobank, HIMC Biobank, PICI Biobank
Stanford University

Steven Harris, M.D.

Adjunct Professor
Psychiatry and Behavioral Sciences

Kristen T. Honey, Ph.D., PMP

Co-Founder, Lyme Innovation
Senior Research Scholar, School of Medicine

Safwan Jaradeh, M.D.

Professor of Neurology

Cheryl Koopman, Ph.D.

Professor (Research) of Psychiatry & Behavioral Sciences, Emerita

Sean Mackey, M.D., Ph.D.

Redlich Professor and 
Professor, by courtesy, of Neurology

Jose Montoya, M.D.

Professor of Medicine (Infectious Diseases and Geographic Medicine)

Jayakumar Rajadas, Ph.D.

Director, BioADD and Assistant Director of CV Pharmacology, BioADD Service Center

Laura Roberts, M.D., M.A.

Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Chairman, 
Department of Psychiatry & Behavioral Sciences 

William Robinson, M.D., Ph.D.

Professor of Medicine
Immunology and Rheumatology

Stanley G. Rockson, MD

Allan and Tina Neill Professor of Lymphatic Research and Medicine

Nazish Sayed M.D., Ph.D.

Instructor, TRAM Scholar

Alfred M. Spormann, Dr. rer. nat.

Professor of Civil and Environmental Engineering, of Chemical Engineering and, by courtesy, of Biology

Michael Snyder, PhD

Chair and Stanford W. Ascherman, MD, FACS, Professor in the Department of Genetics

Michal Tal, Ph.D.

Postdoctoral Fellow in Stem Cell and Regenerative Medicine

Dhananjay Wagh, PhD

Stanford Functional Genomics Facility

Irving Weissman, M.D.

Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology &, by courtesy, of Biology

Nolan Williams, M.D.

Instructor
Psychiatry and Behavioral Sciences

Joseph C. Wu, M.D., Ph.D.
Simon H. Stertzer, MD, Professor of Medicine and Radiology
Director, Stanford Cardiovascular Institute