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Dr. Frankovich is a Clinical Professor in the Department of Pediatrics, Division of Allergy, Immunology Rheumatology (AIR) at Stanford University/Lucile Packard Children’s Hospital (LPCH). Her clinical expertise is in systemic inflammatory and autoimmune diseases that co-occur with psychiatric symptoms. She completed her training in pediatrics, pediatric rheumatology, and clinical epidemiology at Stanford University/LPCH. She directs the Stanford PANS Program (2012- present) where she and her collaborators have created a longitudinal clinical database and large biorepository of patient and healthy control biospecimens. In addition to generating clinical data to better understand immune-behavioral health conditions, she is collaborating with 10 basic science labs who aim to understand the immunological underpinnings of PANS and related conditions.
My primary interest and role at Stanford is to evaluate and treat children with both systemic and organ specific autoimmune disease. In October of 2012, we started a multidisciplinary clinic dedicated to treating patients with PANS (Pediatric Acute-onset Neuropsychiatric Syndromes). I am currently the clinical and research director for the PANS program.
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
Continuation of the CARRA Registry as described in the protocol will support data collection
on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis
for future CARRA studies. In particular, this observational registry will be used to answer
pressing questions about therapeutics used to treat pediatric rheumatic diseases, including
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Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
This study is an investigation of the neurologic, immunologic, and rheumatologic markers of
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by
the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction
accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include
anxiety, emotional lability, depression, irritability, aggression, oppositionality,
deterioration in school performance, behavioral (developmental) regression, sensory
amplification, movement abnormalities, sleep disturbance, and urinary frequency. PANS is
thought to be caused by infection, inflammation, or alternate triggers that is associated
with a brain response that leads to these symptoms. The purpose of this study is to examine
specific neurologic, immunologic, rheumatologic, and genomic, components in children with the
acute-onset of psychiatric symptoms. This research may begin to uncover a much larger story
of autoimmune processes that are involved in psychiatric disorders of childhood. By better
understanding the etiologic components of psychiatric phenomenon, future treatments may be
better targeted to underlying causes.