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Nazish Sayed, MD, PhD is an Assistant Professor in the Department of Surgery, Division of Vascular Surgery and The Stanford Cardiovascular Institute. Dr. Sayed earned his MD degree from the University of Mumbai, India and his PhD degree from the University of Medicine and Dentistry of New Jersey (Rutgers New Jersey Medical School). He has a Master’s degree in Molecular Biology from Montclair State University. He completed his postdoctoral fellowship in cardiovascular and regenerative medicine in the Division of Cardiovascular Medicine at Stanford University followed by an Instructor position at the Stanford Cardiovascular Institute. Dr. Sayed has received numerous awards including the ATVB Young Investigator Award by the American Heart Association and Jay D. Coffman Young Investigator Award by the Society of Vascular Medicine. He has been a recipient of the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32), AHA Scientist Development Grant and the National Institute of Health (NIH), National Heart, Lung, and Blood Institute K-award. His lab is funded by the NIH-NHLBI R01 grant and Stanford SAGE center seed funding.
The Sayed Laboratory is focused on the development of novel technologies that drive innovation in regenerative medicine, disease modeling, and drug testing in vascular biology. The lab conducts translational research in vascular biology and aims to understand the role of the vasculature in the development of cardiac diseases, including those due to inherited genetic variants or environmental insults such as type 2 diabetes or hypertension. The lab employs the human induced pluripotent stem cell (iPSC) technology to generate patient-specific vascular cells (endothelial and vascular smooth muscle cells) as an alternative to animal models providing a human tissue surrogate for research that is scalable and sustainable. By employing this unique platform, the lab also investigates the role of chemotherapeutic agents (anti-cancer drugs) on the vasculature. Dr. Sayed’s lab has also established an endothelial regeneration program, where they leverage the innate immune system to regenerate endothelial cells from human fibroblasts. Work from the lab has led to seminal discoveries in the areas of 1) Nitric oxide (NO) biology, (2) vascular biology, (3) stem cell biology, (4) cardiovascular disease modeling (5) cardio-oncology.