Bio
I am Redlich Professor and Chief of the Division of Stanford Pain Medicine. I am a physician-scientist trained and experienced in neuroimaging, psychophysics, public health, health policy, patient outcomes and medical education. I am guided by our group’s mission “To Predict, Prevent and Alleviate Pain” which encompasses my three goals: (1) define the factors that cause pain to become chronic after injury or surgery, (2) discover and implement novel methods to prevent the persistence or chronification of pain, and (3) discover and test novel therapies to alleviate chronic pain. This vision statement informs the multidisciplinary group I have assembled and the tools my team and I use: advanced neuroimaging, psychophysical and neurobehavioral assessment, genomics, patient- and clinician-reported outcomes, and assessment of pro-inflammatory cytokines.
I have served as principle investigator on multiple NIH awards (PO1, multiple R01’s, U01, K24, T32). Additionally, I hold two endowments that provide the flexible research funds to pursue innovative projects and support our junior investigators. I am the author of over 200 journal articles and book chapters in addition to numerous national and international lectures. Broadly, some of my current research falls into two categories: (1) Characterizing CNS mechanisms of the human pain experience and its modulation and using this to develop biomarkers and (2) development and use of an open-source learning healthcare system (CHOIR; http://choir.stanford.edu) to transform the care of people with pain, and serve as a platform for innovative research in real-world clinic patients. Additionally, we are investigating novel therapies for pain including: transcranial magnetic stimulation, virtual reality, psychological and pharmacological therapies.
Clinical: Under my leadership, the Stanford Pain Management Center has been twice designated a Center of Excellence by the American Pain Society for the Center’s innovative approach in comprehensive, interdisciplinary, and outcomes-based care. We have one of the largest academic pain centers in the country, Stanford Pain Management Center (https://med.stanford.edu/pain.html) with multiple physicians from different disciplines, psychologists, physical therapists, nursing, nutritionists and other professionals all working together to understand and treat the person in pain.
Mentorship: I am the Program Director for our NIH T32 postdoctoral training program “Interdisciplinary Training in Pain and/or Substance Use Disorders”. Furthermore, I have an NIH K24 which funds time to mentor and develop junior investigators. I have a long track record in mentoring of researchers and clinicians to develop their own successful careers.
Leadership: I am Past-President of the American Academy of Pain Medicine (AAPM). I co-authored the Institutes of Medicine’s report on Relieving Pain in America and was Co-Chair of the Oversight Committee for the HHS/NIH National Pain Strategy (NPS), an effort to establish a national health strategy for pain care, education and research. I have received multiple awards for leadership, teaching, research and clinical care.
Clinical Focus
- Chronic Pain
- Pain Management
- Pain Medicine
- Neuropathic Pain
- Complex Regional Pain Syndrome
- Back Pain
- Acute Pain
- reflex sympathetic dystrophy
- Facial Pain
- Headache
- Anesthesia
Academic Appointments
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Professor - Med Center Line, Anesthesiology, Perioperative and Pain Medicine
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Professor - Med Center Line (By courtesy), Neurology & Neurological Sciences
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Member, Bio-X
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Member, Cardiovascular Institute
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Member, Stanford Cancer Institute
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Member, Wu Tsai Neurosciences Institute
Administrative Appointments
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Redlich Professor, Anesthesia & Pain Management, Neurosciences and (by courtesy) Neurology, Stanford University (2012 - Present)
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Chief, Division of Pain Medicine, Stanford University (2007 - Present)
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Fellowship Program Director, Pain Medicine, Stanford University (2007 - Present)
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Associate Professor, Anesthesia & Pain Management, Neurosciences and (by courtesy) Neurology, Stanford University (2007 - 2012)
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Co-Director, Pain Working Group, Neuroscience Institute, Stanford University (2005 - Present)
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Co-Director, Stanford Pain Research and Clinical Center (SPARCC) (2004 - Present)
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Associate Director, Pain Management Division, Stanford University (2004 - 2007)
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Director, Stanford Systems Neuroscience and Pain Lab (SNAPL) (2002 - Present)
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Director (and Co-Founder), Regional Anesthesia Services (2000 - 2006)
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Assistant Professor, Anesthesia & Pain Management, Neurosciences, Stanford University (1999 - 2007)
Honors & Awards
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Robert G. Addison, MD Award, American Academy of Pain Medicine (2020)
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Pain Medicine Fellowship Excellence Award, American Academy of Pain Medicine (2019)
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Presidential Commendation, American Academy of Pain Medicine (2019)
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Distinguished Service Award, American Academy of Pain Medicine (2017)
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Pain Medicine Fellowship Award, American Academy of Pain Medicine (2017)
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Wilbert E. Fordyce Clinical Investigator Award, American Pain Society (2016)
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NIH Directors Award, National Institutes of Health (2015)
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Clinical Center of Excellence, American Pain Society (2012)
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Presidential Commendation, American Academy of Pain Medicine (2012)
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U.S. News and World Report Top 1% of Pain Management Specialists, U.S. News and World Report (2012)
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Stanford CAM Center for Chronic Back Pain, NIH P01 AT006651 (2011-2016)
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Stanford CAM Center for Chronic Back Pain Supplement, NIH P01 AT006651S1 (2011-2012)
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Neuroimaging and Mentoring in Translational Pain Research, NIH K24 DA029262 (2010-2015)
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Ellis Cohen Achievement Award, Department of Anesthesia, Stanford University (2010)
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Chris Redlich Endowment in Pain Research, Chris Redlich Endowment Fund (2009-forever)
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Learned Control of Frontal and Limbic Systems via Real-Time fMRI, NIH R21 DA026092 (2009-2011)
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Development and Applications of Real Time fMRI Technology, Stanford Bio-X (2009-2010)
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Central Mechanisms of Urologic Pelvic Pain: Functional and Structural Analysis by MRI, NIH U01 DK082316 (2008-2013)
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Prescription Opioid Use, Misuse, and Pain in Post-Surgical Patients, NIH K23 DA25152 (2008-2013)
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Low-Dose Naltrexone in the Treatment of Fibromyalgia, American Fibromyalgia Syndrome Association (2008-2009)
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Mechanisms of Opioid-Induced Hyperalgesia in Pain Patients: Examination via fMRI, NIH K99/R00 DA023609 (2007-2011)
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Mechanisms of Analgesic Response During IV Lidocaine Infusion in Neuropathic Pain Patients, Foundation for Anesthesia Education and Research (2007-2008)
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fMRI of Pain in the Human Spinal Cord, NIH R01 NS053961 (2006-2010)
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Duloxetine: Functional MRI Neural Correlates of Efficacy in Patients with Chronic Low Back Pain, Eli Lilly (2006-2009)
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Fellowship Grant, Arthritis Foundation (2006-2007)
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Applications of Real Time fMRI-Phase II, NIH R44 NS050642 (2004-2007)
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Imaging Neural Systems in Complex Regional Pain Syndrome, Foundation for Anesthesia Education & Research (2004-2006)
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Teacher of the Month, Stanford Department of Anesthesia (2003)
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Applications of Real Time fMRI, NIH R43MH067290 (2002-2004)
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Top Doctors in America, Published in "Guide to Top Doctors" (2002, 2004-2006, 2008, 2010, 2012-2015)
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Processing of Pain in the Human Central Nervous System: Analysis through fMRI, Stanford Office of Technology Licensing Grant (2001-2004)
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Use of NMDA-Antagonists and Opiates in the Treatment of Fibromyalgia, Oxnard Foundation (2001-2004)
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Dodie and John Rosekrans Pain Research Endowment Fund, Dodie and John Rosekrans Pain Research Endowment Fund (2001 - forever)
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Cognitive Neurosciences Grant, Clark Center for Bioengeneering, Biomedicine & Bioscience (2000)
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Development of a Human Neuropathic Pain Model, Stanford University (1999-2007)
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Interventional Magnetic Resonance Imaging Applied to Regional Anesthesia and Pain Medicine, Stanford University (1999-2003)
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Electrical and Thermal Characterization of Radiofrequency Catheter Ablation, American College of Cardiology Research Grant (1994)
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TV Catheter Delivery of Elec Energy to Ablate Arrhythmogenic Tissue..., Alpha Omega Alpha Honor Society Research Fellowship (1991-1992)
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Characterization & Optimization of RF Catheter Ablation for the Treatment of Cardiac Arrhythmias, American Heart Association Fellowship (1990-1991)
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Optimal Control of Transvenous Catheter Ablation in the Treatment of Tachyarrhythmias, NIH Short Term Research Fellowship (1989-1994)
Boards, Advisory Committees, Professional Organizations
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Nominating Committee, American Academy of Pain Medicine (2020 - Present)
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Advisory Board Member HSRD Naloxone Distribution IIR, Veterans Affairs (VA) (2020 - 2020)
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Invited Member, FDA & Center for Devices & Radiological Health (CDRH) (2020 - 2020)
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Steering Group, Pain Registries SIG, International Association for the Study of Pain (IASP) (2020 - 2020)
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Technical Expert Panel Member PCOR TEP Pain/OUD, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2020 - 2020)
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Council Member, Council on Science & Public Health, (CMA) (2019 - Present)
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Vice-Chair - Committee on Temporomandibular Disorders (TMD), National Academies of Sciences, National Institutes of Health, (NAS)/(NIH) (2019 - 2020)
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Delegate, California Medical Association, (CMA) (2018 - Present)
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Advisory Committee Member, Drug Safety & Risk Mngt, Anesthetic & Analgesic Drug Products Advisory Comm (DSaRM/AADPAC)/(FDA) (2018 - 2019)
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Committee Member, Committee on Electronic Media & Informatics Technology (EMIT), ASA (2018 - 2018)
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Committee Member Innovations in Medical Devices to Prevent Opioid Use Disorder (OUD), Analgesic, Anesthetic, & Addiction Clinical Trial Translations, Innovations, Opportunities, & Networks (ACTTION) (2018 - 2018)
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Reviewer, American Society of Anesthesiologists Committee on Research (ASA) (2017 - Present)
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Committee Member - Marshaling Physician Leadership to Counter Opioid Epidemic, National Academy of Medicine (2017 - 2017)
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Oversight Committee, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (2017 - 2017)
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Panelist, National Academies of Sciences, Engineering, and Medicine (2017 - 2017)
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Working Group Member to add Pain and Opioid questions to National Health Interview Survey, Centers for Disease Control and Prevention (CDC) (2016 - 2017)
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Board Member, The Association of Pain Program Directors (2015 - Present)
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Immediate Past-President, American Academy of Pain Medicine (2015 - 2016)
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Panelist - Healthy People 2020 Chronic Pain Workgroup, National Institute of Health (NIH) (2014 - 2016)
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President, American Academy of Pain Medicine (2014 - 2015)
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Committee Member, National Comprehensive Cancer Network, Adult Cancer Pain Committee (2013 - Present)
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Co-Chair - Prevention and Care Working Group, National Pain Strategy Task Force (NPSTF) (2013 - 2016)
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Member - Pain Consortium Chronic Low Back Pain Research Task Force, National Institute of Health (NIH) (2013 - 2014)
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Chair, Department of Anesthesia; Stanford School of Medicine, Faculty & Development and Mentoring Committee (2013 - 2013)
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Committee Member, Department of Anesthesia; Stanford School of Medicine, Finance Committee (2012 - Present)
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Co-Chair, National Pain Strategy Task Force (NPSTF) (2012 - 2016)
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Member - Inter agency Pain Research Coordinating Committee, National Institute of Health (NIH) (2012 - 2013)
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Co-Chair Annual Meeting, American Academy of Pain Medicine (2012 - 2012)
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Vice President Scientific Affairs, American Academy of Pain Medicine (2011 - 2013)
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Committee Member & Author, Institute of Medicine (IOM) (2010 - 2011)
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Member, American Academy of Pain Research Committee (2009 - Present)
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Member - CME Oversight Committee, American Academy of Pain Medicine (2009 - Present)
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Member, American Academy of Pain Medicine Executive Committee (2009 - 2015)
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Member, American Pain Society Nominating Committee (2009 - 2011)
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Member - Appointments & Promotions Committee, Department of Anesthesia; Stanford School of Medicine (2008 - Present)
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Director at Large, American Academy of Pain Medicine (2008 - 2015)
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Committee Member, California Department of Workers Compensation (2007 - Present)
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Member - Research Committee, Department of Anesthesia; Stanford School of Medicine (2005 - Present)
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Member - Neuroscience Committee, Stanford University, Neuroscience (2004 - Present)
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Member - Governance Committee, Department of Anesthesia; Stanford School of Medicine (2003 - Present)
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Member - Residency Selection Committee, Department of Anesthesia; Stanford School of Medicine (1999 - Present)
Professional Education
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Fellowship: Stanford University Pain Management Fellowship (1999) CA
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Residency: Stanford University Anesthesiology Residency (1998) CA
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Medical Education: University of Arizona College of Medicine Office of the Registrar (1994) AZ
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Internship: Tucson Medical Center Medical Education Program (1995) AZ
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Board Certification: American Board of Anesthesiology, Pain Management (2000)
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Board Certification: American Board of Anesthesiology, Anesthesia (1999)
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M.D., University of Arizona, Medicine (1994)
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Ph.D., University of Arizona, Electrical Engineering (1994)
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M.S.E, University of Pennsylvania, Bioengineering (1986)
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B.S.E., University of Pennsylvania, Bioengineering (1986)
Patents
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Sean Mackey, Ian Carroll, David Clark. "United States Patent 2005072433 Toxin Induced Sympathectomy", Jan 26, 2004
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Sean Mackey. "United States Patent 5837001 Radio Frequency Energy Delivery System for Multipolar Electrode Catheters", Nov 17, 1998