Clinical Trials

BOOST3 – Brain Oxygen Optimization in Severe TBI Phase 3
BOOST3 is a study to learn if either of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU) is more likely to help them get better. For more information, please see
Protocol ID: 49130
PI: James Quinn, MD

CHARM - Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 for Severe Cerebral Edema following Large Hemispheric Infarction.
The purpose of this study is to evaluate the safety and effectiveness of the study drug, Intravenous BIIB093 (Glibenclamide), in improving functional outcome in subjects with large strokes. NCT02864953
Protocol ID: 46054
PI: Chitra Venkatasubramanian, MBBS, MD

Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH).
This is a randomized, placebo-controlled, subject- and investigator-blinded trial of BAF312 in intracerebral hemorrhage (ICH) patients to study efficacy, safety, and tolerability. BAF312 is a drug that could potentially limit brain inflammation after ICH, and thereby improve neurological outcome for hemorrhagic stroke patients. 
Protocol ID: 43744
PI: Chitra Venkatasubramanian, MBBS, MD

INTREPID - Impact of Fever Prevention in Brain Injured Patients
This study will assess the impact of fever prevention on fever burden and short- and long-term neurologic outcomes in brain injured patients. Half of the subjects will undergo fever prevention using a targeted temperature management system and half of the subjects will be treated for fever should it develop.
Protocol ID: 43136
PI: Chitra Venkatasubramanian, MBBS, MD

CERIBELL Stroke Study
The primary objective of this study is to acquire EEG data in suspected stroke patients, immediately following diagnostic brain imaging to detect potential EEG signals that differ among emergent large vessel occlusion stroke (ELVO), intracranial hemorrhage (ICH), and non-stroke patients (stroke mimics).
Protocol ID: 47822
PI: Anna Finley Caulfield, MD

ICECAP - Influence of Cooling duration on Efficacy in Cardiac Arrest Patients
The purpose of this study is to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.
Protocol ID: 56493
PI: Karen Hirsch, MD
Status: Coming soon

PRECICECAP - PREcision Care In Cardiac ArrEst -ICECAP
In partnership with the ICECAP trial, this project will use novel data-driven approaches to collect high resolution monitoring data from patients in the critical care unit and will use that multi-parametric data to develop newly defined patient sub-groups with differing clinical trajectories and responses to therapies.
Protocol ID: 58318
PI: Karen Hirsch, MD
Status: Coming soon

CyBIO -  A systems-based mass cytometry approach to study the post-cardiac arrest immune response
The goal of this research study is to use Cytometry Time of Flight (CyTOF), a novel methodology, to comprehensively define which individual systemic immune features, at which times, correlate with outcome after cardiac arrest.
Protocol ID: 14447
PI: Karen Hirsch, MD
Status: Recruiting