Publications

Basic mechanisms of epilepsy

Basic science - Prince

Gu F, Parada I, Yang T, Longo FM, Prince DA. Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury. Cereb Cortex. 2020 Jul 30;30(9):5180-5189. 

Perez-Ramirez MB, Gu F, Prince DA. Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury. Neurobiol Dis. 2020 Aug;142:104949. 

Takahashi DK, Gu F, Parada I, Vyas S, Prince DA. Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma. Neurobiol Dis. 2016 Jul;91:166-81. 

Gu F, Parada I, Yang T, Longo FM, Prince DA. Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons. Neurobiol Dis. 2018 May;113:45-58. 

DK, Jin S, Prince DA. Gabapentin Prevents Progressive Increases in Excitatory Connectivity and Epileptogenesis Following Neocortical Trauma. Cereb Cortex. 2018 Aug 1;28(8):2725-2740. 

Gu F, Parada I, Shen F, Li J, Bacci A, Graber K, Taghavi RM, Scalise K, Schwartzkroin P, Wenzel J, Prince DA. Structural alterations in fast-spiking GABAergic interneurons in a model of posttraumatic neocortical epileptogenesis. Neurobiol Dis. 2017 Dec;108:100-114.

Faria LC, Gu F, Parada I, Barres B, Luo ZD, Prince DA. Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit α2δ-1. Neurobiol Dis. 2017 Jun;102:70-80. 

Antiepileptogenic repair of excitatory and inhibitory synaptic connectivity after neocortical trauma. Prog Brain Res. 2016;226:209-27.

Basic science - Huguenard

Lu AC, Lee CK, Kleiman-Weiner M, Truong B, Wang M, Huguenard J, Beenhakker MP. Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations. Elife. 2020 Sep 9;9:e59548. doi: 10.7554/eLife.59548. 

Huguenard J. Current Controversy: Spikes, Bursts, and Synchrony in Generalized Absence Epilepsy: Unresolved Questions Regarding Thalamocortical Synchrony in Absence Epilepsy. Epilepsy Curr. 2019 Mar-Apr;19(2):105-111. 

Marton RM, Miura Y, Sloan SA, Li Q, Revah O, Levy RJ, Huguenard JR, Pașca SP. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures. Nat Neurosci. 2019 Mar;22(3):484-491.

Yoon SJ, Elahi LS, Pașca AM, Marton RM, Gordon A, Revah O, Miura Y, Walczak EM, Holdgate GM, Fan HC, Huguenard JR, Geschwind DH, Pașca SP. Reliability of human cortical organoid generation. Nat Methods. 2019 Jan;16(1):75-78.

Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. Front Mol Neurosci. 2018 Nov 9;11:405. doi: 10.3389/fnmol.2018.00405

Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, DeLoach KE, Ran C, Pun A, Sun Y, Weissbourd B, Neve RL, Huguenard J, Horowitz MA, Luo L. Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell. 2018 Oct 4;175(2):472-487

Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O'Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Paşca SP. Assembly of functionally integrated human forebrain spheroids. Nature. 2017 May 4;545(7652):54-59. 

Yackle K, Schwarz LA, Kam K, Sorokin JM, Huguenard JR, Feldman JL, Luo L, Krasnow MA. Breathing control center neurons that promote arousal in mice. Science. 2017 Mar 31;355(6332):1411-1415.

Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR. Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. 2017 Mar 8;93(5):1165-1179

Fogerson PM, Huguenard JR. Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations. Neuron. 2016 Nov 23;92(4):687-704. 

Sorokin JM, Paz JT, Huguenard JR. Absence seizure susceptibility correlates with pre-ictal β oscillations. J Physiol Paris. 2016 Nov;110(4 Pt A):372-381. 

Brill J, Mattis J, Deisseroth K, Huguenard JR. LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition. eNeuro. 2016 Aug 8;3(4):ENEURO.0142-15.2016.

Deleuze C, Huguenard JR. Two classes of excitatory synaptic responses in rat thalamic reticular neurons. J Neurophysiol. 2016 Sep 1;116(3):995-1011. 

Paz JT, Huguenard JR. Microcircuits and their interactions in epilepsy: is the focus out of focus? Nat Neurosci. 2015 Mar;18(3):351-9. 

Paz JT, Huguenard JR. Optogenetics and epilepsy: past, present and future. Epilepsy Curr. 2015 Jan-Feb;15(1):34-8. 

Farzampour Z, Reimer RJ, Huguenard J. Endozepines. Adv Pharmacol. 2015;72:147-64. 

Basic science - Soltesz

Allen BD, Syage AR, Maroso M, Baddour AAD, Luong V, Minasyan H, Giedzinski E, West BL, Soltesz I, Limoli CL, Baulch JE, Acharya MM. Mitigation of helium irradiation-induced brain injury by microglia depletion. J Neuroinflammation. 2020 May 19;17(1):159.  

Nguyen QA, Moolchand P, Soltesz I. Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures. Trends Neurosci. 2020 Aug;43(8):547-549.  

Dey D, Parihar VK, Szabo GG, Klein PM, Tran J, Moayyad J, Ahmed F, Nguyen QA, Murry A, Merriott D, Nguyen B, Goldman J, Angulo MC, Piomelli D, Soltzsz I, Baulch JE, Limoli CL. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiat Res. 2020 May;193(5):407-424.

Optogenetic intervention of seizures improves spatial memory in a mouse model of chronic temporal lobe epilepsy. Epilepsia. 2020 Mar;61(3):561-571.

Ripple-related firing of identified deep CA1 pyramidal cells in chronic temporal lobe epilepsy in mice. Epilepsia Open. 2019 Mar 4;4(2):254-263.

Farrell JS, Colangeli R, Dudok B, Wolff MD, Nguyen SL, Jackson J, Dickson CT, Soltesz I, Teskey GC. In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia. Sci Rep. 2020 Sep 14;10(1):14992.

Plants come to mind: phytocannabinoids, endocannabinoids and the control of seizures. Addiction. 2019 Aug;114(8):1343-1345.  

Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B, Leschik J. Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cereb Cortex. 2018 Dec 1;28(12):4454-4471.  

Soltesz I, Losonczy A. CA1 pyramidal cell diversity enabling parallel information processing in the hippocampus. Nat Neurosci. 2018 Apr;21(4):484-493.  

Huizenga MN, Fureman BE, Soltesz I, Stella N. Proceedings of the Epilepsy Foundation's 2017 Cannabinoids in Epilepsy Therapy Workshop. Epilepsy Behav. 2018 Aug;85:237-242.  

Parihar VK, Maroso M, Syage A, Allen BD, Angulo MC, Soltesz I, Limoli CL. Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice. Exp Neurol. 2018 Jul;305:44-55.

Bui AD, Nguyen TM, Limouse C, Kim HK, Szabo GG, Felong S, Maroso M, Soltesz I. Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory. Science. 2018 Feb 16;359(6377):787-790.

Neubrandt M, Oláh VJ, Brunner J, Marosi EL, Soltesz I, Szabadics J. Single Bursts of Individual Granule Cells Functionally Rearrange Feedforward Inhibition. J Neurosci. 2018 Feb 14;38(7):1711-1724.

Neumann AR, Raedt R, Steenland HW, Sprengers M, Bzymek K, Navratilova Z, Mesina L, Xie J, Lapointe V, Kloosterman F, Vonck K, Boon PAJM, Soltesz I, McNaughton BL, Luczak A. Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy. Brain. 2017 Sep 1;140(9):2355-2369.  

Neumann AR, Raedt R, Steenland HW, Sprengers M, Bzymek K, Navratilova Z, Mesina L, Xie J, Lapointe V, Kloosterman F, Vonck K, Boon PAJM, Soltesz I, McNaughton BL, Luczak A. Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy. Brain. 2017 Sep 1;140(9):2355-2369.  

Szabo GG, Du X, Oijala M, Varga C, Parent JM, Soltesz I. Extended Interneuronal Network of the Dentate Gyrus. Cell Rep. 2017 Aug 8;20(6):1262-1268.  

Bui AD, Alexander A, Soltesz I. Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy. Neuroscientist. 2017 Feb;23(1):68-81.

Bezaire MJ, Raikov I, Burk K, Vyas D, Soltesz I. Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. Elife. 2016 Dec 23;5:e18566.  

Alexander A, Maroso M, Soltesz I. Organization and control of epileptic circuits in temporal lobe epilepsy. Prog Brain Res. 2016;226:127-54.  

Alexander A, Soltesz I. Hippogate: a break-in from entorhinal cortex. Nat Neurosci. 2016 Apr;19(4):530-2.  

Maroso M, Szabo GG, Kim HK, Alexander A, Bui AD, Lee SH, Lutz B, Soltesz I. Cannabinoid Control of Learning and Memory through HCN Channels. Neuron. 2016 Mar 2;89(5):1059-73.  

Bui AD, Alexander A, Soltesz I. Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy. Neuroscientist. 2017 Feb;23(1):68-81.  

Armstrong C, Wang J, Yeun Lee S, Broderick J, Bezaire MJ, Lee SH, Soltesz I. Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals. Hippocampus. 2016 Jun;26(6):779-93.  

Ewell LA, Liang L, Armstrong C, Soltész I, Leutgeb S, Leutgeb JK. Brain State Is a Major Factor in Preseizure Hippocampal Network Activity and Influences Success of Seizure Intervention. J Neurosci. 2015 Nov 25;35(47):15635-48.

Szabo GG, Soltesz I. Pass-Through Code of Synaptic Integration. Neuron. 2015 Sep 23;87(6):1124-1126.  

Adamantidis A, . . . Huguenard JR, . . . Malenka RC, . . . Soltesz I, . . .  Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci. 2015 Sep;18(9):1202-12. 

Classification of Seizures and Definition of Epilepsy

Fisher RS, Cross H, D'Souza C, French JA, Haut S, Higurashi N, Hirsch E, Jansen FE, Peltola J, Moshé SL, Perucca E, Lagae L, Roulet-Perez E, Schulze-Bonhage A, Scheffer IE, Somerville E, Sperling MR, Wiebe S, Yacubian EM, Zuberi S. 2017 International League Against Epilepsy classifications of seizures and epilepsy are steps in the right direction. Epilepsia. 2019 Jun;60(6):1040-1044. 

Brodie MJ, Zuberi SM, Scheffer IE, Fisher RS. The 2017 ILAE classification of seizure types and the epilepsies: what do people with epilepsy and their caregivers need to know? Epileptic Disord. 2018 Apr 1;20(2):77-87. 

Fisher RS, Bonner AM. The Revised Definition and Classification of Epilepsy for Neurodiagnostic Technologists. Neurodiagn J. 2018;58(1):1-10.

Falco-Walter JJ, Scheffer IE, Fisher RS. The new definition and classification of seizures and epilepsy. Epilepsy Res. 2018 Jan;139:73-79.

Fisher RS, et al. . Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017 Apr;58(4):522-530.

Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia. 2017 Apr;58(4):531-542.

Fisher RS. The New Classification of Seizures by the International League Against Epilepsy 2017. Curr Neurol Neurosci Rep. 2017 Jun;17(6):48. doi: 10.1007/s11910-017-0758-6

Fisher RS. An overview of the 2017 ILAE operational classification of seizure types. Epilepsy Behav. 2017 May;70(Pt A):271-273. 

Fisher RS. Redefining epilepsy. Curr Opin Neurol. 2015 Apr;28(2):130-5. 

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-82.

Cognitive Issues in Epilepsy

Meador KJ, Seliger J, Boyd A, Razavi B, Falco-Walter J, Le S, Loring DW. Comparative neuropsychological effects of carbamazepine and eslicarbazepine acetate. Epilepsy Behav. 2019 May;94:151-157.

Piña-Garza JE, Lagae L, Villanueva V, Renfroe JB, Laurenza A, Williams B, Kumar D, Meador KJ. Long-term effects of adjunctive perampanel on cognition in adolescents with partial seizures. Epilepsy Behav. 2018 Jun;83:50-58. doi: 10.1016/j.yebeh.2018.03.029. Epub 2018 Apr 10. PMID: 29653338.

Leeman-Markowski BA, Meador KJ, Moo LR, Cole AJ, Hoch DB, Garcia E, Schachter SC. Does memantine improve memory in subjects with focal-onset epilepsy and memory dysfunction? A randomized, double-blind, placebo-controlled trial. Epilepsy Behav. 2018 Nov;88:315-324. 

Adams J, Alipio-Jocson V, Inoyama K, Bartlett V, Sandhu S, Oso J, Barry JJ, Loring DW, Meador KJ. Methylphenidate, cognition, and epilepsy: A 1-month open-label trial. Epilepsia. 2017 Dec;58(12):2124-2132. 

Meador KJ, Loring DW, Boyd A, Echauz J, LaRoche S, Velez-Ruiz N, Korb P, Byrnes W, Dilley D, Borghs S, De Backer M, Story T, Dedeken P, Webster E. Randomized double-blind comparison of cognitive and EEG effects of lacosamide and carbamazepine. Epilepsy Behav. 2016 Sep;62:267-75.

Meador KJ, Yang H, Piña-Garza JE, Laurenza A, Kumar D, Wesnes KA. Cognitive effects of adjunctive perampanel for partial-onset seizures: A randomized trial. Epilepsia. 2016 Feb;57(2):243-51.

Depth Recording to Elucidate Brain Anatomy and Mechanisms

Schrouff J, Raccah O, Baek S, Rangarajan V, Salehi S, Mourão-Miranda J, Helili Z, Daitch AL, Parvizi J. Fast temporal dynamics and causal relevance of face processing in the human temporal cortex. Nat Commun. 2020 Jan 31;11(1):656.

Vesuna S, Kauvar IV, Richman E, Gore F, Oskotsky T, Sava-Segal C, Luo L, Malenka RC, Henderson JM, Nuyujukian P, Parvizi J, Deisseroth K. Deep posteromedial cortical rhythm in dissociation. Nature. 2020 Sep 16. doi: 10.1038/s41586-020-2731-9.  

Bickel S, Parvizi J. Electrical stimulation of the human claustrum. Epilepsy Behav. 2019 Aug;97:296-303.  

Liu S, Parvizi J. Cognitive refractory state caused by spontaneous epileptic high-frequency oscillations in the human brain. Sci Transl Med. 2019 Oct 16;11(514):eaax7830.  

Yih J, Beam DE, Fox KCR, Parvizi J. Intensity of affective experience is modulated by magnitude of intracranial electrical stimulation in human orbitofrontal, cingulate and insular cortices. Soc Cogn Affect Neurosci. 2019 May 17;14(4):339-351.  

Baek S, Daitch AL, Pinheiro-Chagas P, Parvizi J. Neuronal Population Responses in the Human Ventral Temporal and Lateral Parietal Cortex during Arithmetic Processing with Digits and Number Words. J Cogn Neurosci. 2018 Sep;30(9):1315-1322.

Fox KCR, Yih J, Raccah O, Pendekanti SL, Limbach LE, Maydan DD, Parvizi J. Changes in subjective experience elicited by direct stimulation of the human orbitofrontal cortex. Neurology. 2018 Oct 16;91(16):e1519-e1527.

Parvizi J, Wagner AD.  Memory, Numbers, and Action Decision in Human Posterior Parietal Cortex. Neuron. 2018: 01 03;97(1):7-10.

Pendekanti S, Baek S, Kilinc YB, Parvizi J. High-level visual manifestations of epileptic seizures originating from the medial parietal cortex. Epileptic Disneord. 2018 Jun 1;20(3):200-203.  

Perry A, Stiso J, Chang EF, Lin JJ, Parvizi J, Knight RT. Mirroring in the Human Brain: Deciphering the Spatial-Temporal Patterns of the Human Mirror Neuron System. Cereb Cortex. 2018 Mar 1;28(3):1039-1048.  

Pinheiro-Chagas P, Daitch A, Parvizi J, Dehaene S. Brain Mechanisms of Arithmetic: A Crucial Role for Ventral Temporal Cortex. J Cogn Neurosci. 2018 Dec;30(12):1757-1772

Saez I, Lin J, Stolk A, Chang E, Parvizi J, Schalk G, Knight RT, Hsu M. Encoding of Multiple Reward-Related Computations in Transient and Sustained High-Frequency Activity in Human OFC. Curr Biol. 2018 Sep 24;28(18):2889-2899.

Hermes D, Rangarajan V, Foster BL, King JR, Kasikci I, Miller KJ, Parvizi J. Electrophysiological Responses in the Ventral Temporal Cortex During Reading of Numerals and Calculation. Cereb Cortex. 2017 Jan 1;27(1):567-575.

Jiang H, Schuele S, Rosenow J, Zelano C, Parvizi J, Tao JX, Wu S, Gottfried JA. Theta Oscillations Rapidly Convey Odor-Specific Content in Human Piriform Cortex. Neuron. 2017 Apr 5;94(1):207-219.e4.  

Fonken YM, Rieger JW, Tzvi E, Crone NE, Chang E, Parvizi J, Knight RT, Krämer UM. Frontal and motor cortex contributions to response inhibition: evidence from electrocorticography. J Neurophysiol. 2016 Apr;115(4):2224-36.  

Piai V, Anderson KL, Lin JJ, Dewar C, Parvizi J, Dronkers NF, Knight RT. Direct brain recordings reveal hippocampal rhythm underpinnings of language processing. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11366-11371.  

Leeman-Markowski BA, Smart OL, Faught RE, Gross RE, Meador KJ. Cessation of gamma activity in the dorsomedial nucleus associated with loss of consciousness during focal seizures. Epilepsy Behav. 2015 Oct;51:215-20. 

Diaries for Epilepsy and Seizure Detection

Werbaneth K, Cramer JA, Bartfeld E., Fisher RS. Identification of Seizure Clusters using free text notes in an electronic seizure diary Epilepsy & Behavior 2020 in press

Shum J, Fogarty A, Dugan P, Holmes MG, Leeman-Markowski BA, Liu AA, Fisher RS, Friedman D. Sounds of seizures. Seizure. 2020 May;78:86-90.

Quigg M, Skarpaas TL, Spencer DC, Fountain NB, Jarosiewicz B, Morrell MJ. Electrocorticographic events from long-term ambulatory brain recordings can potentially supplement seizure diaries. Epilepsy Res. 2020 Mar;161:106302.

Fisher RS. Bad information in epilepsy care. Epilepsy Behav. 2017 Feb;67:133-134.

Aghaei-Lasboo A, Fisher RS. Methods for Measuring Seizure Frequency and Severity. Neurol Clin. 2016 May;34(2):383-94.

Velez M, Fisher RS, Bartlett V, Le S. Tracking generalized tonic-clonic seizures with a wrist accelerometer linked to an online database. Seizure. 2016 Jul;39:13-18. 

Fisher RS, Bartfeld E, Cramer JA, Use of an online epilepsy diary to characterize repetitive seizures. Epilepsy Behav, 2015. 47: p. 66-71.

EEG

EEG Value

Drs. Kuo, Lee-Messer and Le analyze optimal duration of aEEG recordings

Kuo J, Lee-Messer C, Le S. Optimal recording duration of ambulatory EEG (aEEG). Epilepsy Res. 2019 Jan;149:9-12. 

Wiley SL, Razavi B, Krishnamohan P, Mlynash M, Eyngorn I, Meador KJ, Hirsch KG. Quantitative EEG Metrics Differ Between Outcome Groups and Change Over the First 72 h in Comatose Cardiac Arrest Patients. Neurocrit Care. 2018 Feb;28(1):51-59. 

Bican O, Cho C, Suarez-Roman A, Nguyen V, Lee L, Le S, Heit J, Dodd R, López J. Superselective methohexital challenge prior to intracranial endovascular embolization. J Clin Neurosci. 2019 May;63:68-71.

Electroencephalographic features of moyamoya in adults. Clin Neurophysiol. 2015 Mar;126(3):481-5.

EEG Neonatal

Wusthoff CJ, Sullivan J, Glass HC, Shellhaas RA, Abend NS, Chang T, Tsuchida TN. Interrater agreement in the interpretation of neonatal electroencephalography in hypoxic-ischemic encephalopathy. Epilepsia. 2017 Mar;58(3):429-435.

Shellhaas RA, Wusthoff CJ, Tsuchida TN, Glass HC, Chu CJ, Massey SL, Soul JS, Wiwattanadittakun N, Abend NS, Cilio MR; Neonatal Seizure Registry. Profile of neonatal epilepsies: Characteristics of a prospective US cohort. Neurology. 2017 Aug 29;89(9):893-899. 

Lee JW, . . .Wusthoff CJ, . . . ; Critical Care EEG Monitoring Research Consortium (CCEMRC). Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. J Clin Neurophysiol. 2016 Apr;33(2):133-40. 

EEG New Technology

Aghaei-Lasboo A, Inoyama K, Fogarty AS, Kuo J, Meador KJ, Walter JJ, Le ST, Graber KD, Razavi B, Fisher RS. Tripolar concentric EEG electrodes reduce noise. Clin Neurophysiol. 2020 Jan;131(1):193-198.

Gururangan K, Parvizi J. Midline and Parasagittal Seizures are Rare in Adult Patients. Neurocrit Care. 2020 Feb;32(1):193-197.

Hobbs K, Krishnamohan P, Legault C, Goodman S, Parvizi J, Gururangan K, Mlynash M. Rapid Bedside Evaluation of Seizures in the ICU by Listening to the Sound of Brainwaves: A Prospective Observational Clinical Trial of Ceribell's Brain Stethoscope Function. Neurocrit Care. 2018 Oct;29(2):302-312.

Gururangan K, Razavi B, Parvizi J. Diagnostic utility of eight-channel EEG for detecting generalized or hemispheric seizures and rhythmic periodic patterns. Clin Neurophysiol Pract. 2018 Mar 26;3:65-73. 

Ho AL, Feng AY, Kim LH, Pendharkar AV, Sussman ES, Halpern CH, Grant GA. Stereoelectroencephalography in children: a review. Neurosurg Focus. 2018 Sep;45(3):E7. doi: 10.3171/2018.6.

Fisher RS, Burdelle ME. The Next Paradigm Change in EEG Recording: What Will it Mean for EEG Technologists? Neurodiagn J. 2018;58(3):140-142. 

Gururangan K, Razavi B, Parvizi J. Utility of electroencephalography: Experience from a U.S. tertiary care medical center. Clin Neurophysiol. 2016 Oct;127(10):3335-40. 

Tomlinson SB, Bermudez C, Conley C, Brown MW, Porter BE, Marsh ED. Spatiotemporal Mapping of Interictal Spike Propagation: A Novel Methodology Applied to Pediatric Intracranial EEG Recordings. Front Neurol. 2016 Dec 19;7:229. doi: 10.3389/fneur.2016.00229.

Genetics

Walker DI, Perry-Walker K, Finnell RH, Pennell KD, Tran V, May RC, McElrath TF, Meador KJ, Pennell PB, Jones DP. Metabolome-wide association study of anti-epileptic drug treatment during pregnancy. Toxicol Appl Pharmacol. 2019 Jan 15;363:122-130.

Gerard EE, Meador KJ. An Update on Maternal Use of Antiepileptic Medications in Pregnancy and Neurodevelopment Outcomes. J Pediatr Genet. 2015 Jun;4(2):94-110.

Guerrini R, Meador KJ. Breaking up genetic influences on seizure onset, spread, and termination. Neurology. 2020 Sep 11:10.1212/WNL.0000000000010760.

Meador KJ, Shin C. Pitfalls in developing precision medicine for genetic epilepsy. Neurology. 2018 Jan 2;90(1):16-17.

Ottman R, Freyer C, Mefford HC, Poduri A, Lowenstein DH and Epilepsy Return of Results Workshop Participants, including Fisher RS. Return of individual results in epilepsy genomic research: A view from the field. Epilepsia. 2018 Sep;59(9):1635-1642.  

Ketogenic Diet

Roehl K, Falco-Walter J, Ouyang B, Balabanov A. Modified ketogenic diets in adults with refractory epilepsy: Efficacious improvements in seizure frequency, seizure severity, and quality of life. Epilepsy Behav. 2019 Apr;93:113-118.

Do certain subpopulations of adults with drug-resistant epilepsy respond better to modified ketogenic diet treatments? Evaluation based on prior resective surgery, type of epilepsy, imaging abnormalities, and vagal nerve stimulation. Epilepsy Behav. 2019 Apr;93:119-124.

Machine Intelligence and Computing in Epilepsy

Saab K, Dunnmon J, Ré C, Rubin D, Lee-Messer C. Weak supervision as an efficient approach for automated seizure detection in electroencephalography. NPJ Digit Med. 2020 Apr 20;3:59. doi: 10.1038/s41746-020-0264-0.

Dunnmon JA, Ratner AJ, Saab K, Khandwala N, Markert M, Sagreiya H, Goldman R, Lee-Messer C, Lungren MP, Rubin DL, Ré C. Cross-Modal Data Programming Enables Rapid Medical Machine Learning. Patterns (N Y). 2020 May 8;1(2):100019. doi: 10.1016/j.patter.2020.100019. Epub 2020 Apr 28. PMID: 32776018

Schrouff J, Mourão-Miranda J, Phillips C, Parvizi J. Decoding intracranial EEG data with multiple kernel learning method. J Neurosci Methods. 2016 Mar 1;261:19-28. 

Leeman-Markowski BA, Smart OL, Faught RE, Gross RE, Meador KJ. Cessation of gamma activity in the dorsomedial nucleus associated with loss of consciousness during focal seizures. Epilepsy Behav. 2015 Oct;51:215-20.  

Networks

Kucyi A, Daitch A, Raccah O, Zhao B, Zhang C, Esterman M, Zeineh M, Halpern CH, Zhang K, Zhang J, Parvizi J. Electrophysiological dynamics of antagonistic brain networks reflect attentional fluctuations. Nat Commun. 2020 Jan 16;11(1):325. 

Guo ZH, Zhao BT, Toprani S, Hu WH, Zhang C, Wang X, Sang L, Ma YS, Shao XQ, Razavi B, Parvizi J, Fisher R, Zhang JG, Zhang K. Epileptogenic network of focal epilepsies mapped with cortico-cortical evoked potentials. Clin Neurophysiol. 2020 Sep 2;131(11):2657-2666.

Farrell JS, Nguyen QA, Soltesz I. Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks. Neuron. 2019 Mar 20;101(6):1016-1028.

Fox KCR, Foster BL, Kucyi A, Daitch AL, Parvizi J. Intracranial Electrophysiology of the Human Default Network. Trends Cogn Sci. 2018 Apr;22(4):307-324.

Raccah O, Daitch AL, Kucyi A, Parvizi J. Direct Cortical Recordings Suggest Temporal Order of Task-Evoked Responses in Human Dorsal Attention and Default Networks. J Neurosci. 2018 Nov 28;38(48):10305-10313. 

Kucyi A, Schrouff J, Bickel S, Foster BL, Shine JM, Parvizi J. Intracranial Electrophysiology Reveals Reproducible Intrinsic Functional Connectivity within Human Brain Networks. J Neurosci. 2018 Apr 25;38(17):4230-4242. 

Sorokin JM, Davidson TJ, Frechette E, Abramian AM, Deisseroth K, Huguenard JR, Paz JT. Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron. 2017 Jan 4;93(1):194-210. doi: 10.1016/j.neuron.2016.11.026.

Tomlinson SB, Porter BE, Marsh ED. Interictal network synchrony and local heterogeneity predict epilepsy surgery outcome among pediatric patients. Epilepsia. 2017 Mar;58(3):402-411.

Alexander A, Maroso M, Soltesz I. Organization and control of epileptic circuits in temporal lobe epilepsy. Prog Brain Res. 2016;226:127-54

Weitz AJ, Fang Z, Lee HJ, Fisher RS, Smith WC, Choy M, Liu J, Lin P, Rosenberg M, Lee JH. Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations. Neuroimage. 2015 Feb 15;107:229-241.

Liu J, Lee HJ, Weitz AJ, Fang Z, Lin P, Choy M, Fisher R, Pinskiy V, Tolpygo A, Mitra P, Schiff N, Lee JH. Frequency-selective control of cortical and subcortical networks by central thalamus. Elife. 2015 Dec 10;4:e09215. doi: 10.7554/eLife.09215.  

Neuromodulation

Neuromodulation-VNS

Markert MS, Fisher RS. Neuromodulation - Science and Practice in Epilepsy: Vagus Nerve Stimulation, Thalamic Deep Brain Stimulation, and Responsive NeuroStimulation. Expert Rev Neurother. 2019 Jan;19(1):17-29. 

Fisher RS, et al. Automatic Vagus Nerve Stimulation Triggered by Ictal Tachycardia: Clinical Outcomes and Device Performance--The U.S. E-37 Trial. Neuromodulation. 2016 Feb;19(2):188-95.

Fisher RS, Eggleston KS, Wright CW. Vagus nerve stimulation magnet activation for seizures: a critical review. Acta Neurol Scand. 2015 Jan;131(1):1-8.

Neuromodulation-RNS

Razavi B, Rao VR, Lin C, Bujarski KA, Patra SE, Burdette DE, Geller EB, Brown MM, Johnson EA, Drees C, Chang EF, Greenwood JE, Heck CN, Jobst BC, Gwinn RP, Warner NM, Halpern CH. Real-world experience with direct brain-responsive neurostimulation for focal onset seizures. Epilepsia. 2020 Jul 13. doi: 10.1111/epi.16593. 

Jarosiewicz B, Morrell M. The RNS System: brain-responsive neurostimulation for the treatment of epilepsy. Expert Rev Med Devices. 2020 Sep 16:1-10.

Nair Dr . . . Morrell M. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy. Neurology. 2020 Sep 1;95(9):e1244-e1256.

Arcot Desai S, Tcheng TK, Morrell MJ. Quantitative electrocorticographic biomarkers of clinical outcomes in mesial temporal lobe epileptic patients treated with the RNS® system. Clin Neurophysiol. 2019 Aug;130(8):1364-1374.

Skarpaas TL, Tcheng TK, Morrell MJ. Clinical and electrocorticographic response to antiepileptic drugs in patients treated with responsive stimulation. Epilepsy Behav. 2018 Jun;83:192-200.

Sun FT, Arcot Desai S, Tcheng TK, Morrell MJ.  Changes in the electrocorticogram after implantation of intracranial electrodes in humans: The implant effect. Clin Neurophysiol. 2018 Mar;129(3):676-686.

Geller EB,  . . . Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia. 2017 Jun;58(6):994-1004.

Jobst BC, . . . Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia. 2017 Jun;58(6):1005-1014.

Morrell MJ, Halpern C. Responsive Direct Brain Stimulation for Epilepsy. Neurosurg Clin N Am. 2016 Jan;27(1):111-21.

Miller KJ, Burns TC, Grant GA, Halpern CH. Responsive stimulation of motor cortex for medically and surgically refractive epilepsy. Seizure. 2015 Dec;33:38-40.

Loring DW, Kapur R, Meador KJ, Morrell MJ. Differential neuropsychological outcomes following targeted responsive neurostimulation for partial-onset epilepsy. Epilepsia. 2015 Nov;56(11):1836-44.

Meador KJ, Kapur R, Loring DW, Kanner AM, Morrell MJ; RNS® System Pivotal Trial Investigators. Quality of life and mood in patients with medically intractable epilepsy treated with targeted responsive neurostimulation. Epilepsy Behav. 2015 Apr;45:242-7.

King-Stephens D, . . . Morrell MJ. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia. 2015 Jun;56(6):959-67.

Neuromodulation-DBS

Zeitler M, Tass PA. Computationally Developed Sham Stimulation Protocol for Multichannel Desynchronizing Stimulation. Front Physiol. 2018 May 8;9:512. doi: 10.3389

Tröster AI, Meador KJ, Irwin CP, Fisher RS; SANTE Study Group. Memory and mood outcomes after anterior thalamic stimulation for refractory partial epilepsy. Seizure. 2017 Feb;45:133-141.

Fisher RS. Stimulation of the medial septum should benefit patients with temporal lobe epilepsy. Med Hypotheses. 2015 Jun;84(6):543-50. 

Salanova V, . . . Fisher R; SANTE Study Group. Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy. Neurology. 2015 Mar 10;84(10):1017-25.

Neuromodulation-Transcranial Magnetic stimulation

Fisher R, Zhou J, Fogarty A, Joshi A, Markert M, Deutsch GK, Velez M. Repetitive transcranial magnetic stimulation directed to a seizure focus localized by high-density EEG: A case report. Epilepsy Behav Case Rep. 2018 Apr 18;10:47-53. 

Baumer FM, Pfeifer K, Fogarty A, Pena-Solorzano D, Rolle CE, Wallace JL, Rotenberg A, Fisher RS. Cortical Excitability, Synaptic Plasticity, and Cognition in Benign Epilepsy With Centrotemporal Spikes: A Pilot TMS-EMG-EEG Study. J Clin Neurophysiol. 2020 Mar;37(2):170-180.

Baumer FM, Rotenberg A. Emerging Applications of Noninvasive Brain Stimulation. J Clin Neurophysiol. 2020 Mar;37(2):89. doi: 10.1097

Mahajan UV, Parker JJ, Williams NR, Bhati MT, Ku S, Grant G, Fisher RS, Stein SC, Halpern CH. Adjunctive repetitive transcranial magnetic stimulation delivers superior quality of life for focal epilepsy compared to anti-epileptic drugs: A meta-analytic utility prediction study. Brain Stimul. 2020 Mar-Apr;13(2):430-432.  

Neuroimaging

Lamsam L, Bhambhvani HP, Ratliff JK, Kvam KA. Emergent neuroimaging for seizures in epilepsy: A population study. Epilepsy Behav. 2020 Sep 7;112:107339. doi: 10.1016/j.yebeh.2020.107339.

Kvam KA, Douglas VC, Whetstone WD, Josephson SA, Betjemann JP. Yield of Emergent CT in Patients With Epilepsy Presenting With a Seizure. Neurohospitalist. 2019 Apr;9(2):71-78.

Tranvinh E, Lanzman B, Provenzale J, Wintermark M. Imaging Evaluation of the Adult Presenting With New-Onset Seizure. AJR Am J Roentgenol. 2019 Jan;212(1):15-25.

Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 Sep;142(3):e20180672.

Parekh MB, Rutt BK, Purcell R, Chen Y, Zeineh MM. Ultra-high resolution in-vivo 7.0T structural imaging of the human hippocampus reveals the endfolial pathway. Neuroimage. 2015 May 15;112:1-6.

Photosensitive Epilepsy

Baumer FM, Porter BE. Clinical and electrographic features of sunflower syndrome. Epilepsy Res. 2018 May;142:58-63. 

Fisher RS, Harding G, Erba G, Barkley GL, Wilkins A; Epilepsy Foundation of America Working Group. Photic- and pattern-induced seizures: a review for the Epilepsy Foundation of America Working Group. Epilepsia. 2005 Sep;46(9):1426-41.

Harding G, Wilkins AJ, Erba G, Barkley GL, Fisher RS; Epilepsy Foundation of America Working Group. Photic- and pattern-induced seizures: expert consensus of the Epilepsy Foundation of America Working Group. Epilepsia. 2005 Sep;46(9):1423-5.  

Pregnancy and Women’s Issues

Tomson T, Battino D, Bromley R, Kochen S, Meador K, Pennell P, Thomas SV. Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy. Epileptic Disord. 2019 Dec 1;21(6):497-517.liu

Cohen MJ, Meador KJ, May R, Loblein H, Conrad T, Baker GA, Bromley RL, Clayton-Smith J, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group. Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study. Epilepsy Behav. 2019 Mar;92:154-164.

Meador KJ, et al.; MONEAD Investigator Group. Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology. 2020 Apr 7;94(14):e1502-e1511.

Birnbaum AK, Meador KJ, Karanam A, Brown C, May RC, Gerard EE, Gedzelman ER, Penovich PE, Kalayjian LA, Cavitt J, Pack AM, Miller JW, Stowe ZN, Pennell PB; MONEAD Investigator Group. Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy. JAMA Neurol. 2020 Apr 1;77(4):441-450.

Kellogg M, Meador KJ. Neurodevelopmental Effects of Antiepileptic Drugs. Neurochem Res. 2017 Jul;42(7):2065-2070.

Mawer G, Bromley R, Baker GA, Meador KJ, Clayton-Smith J. Fine-tuning risk assessment with antiepileptic drug use in pregnancy. Neurology. 2015 Oct 13;85(15):1354. 

Meador KJ. Risks during pregnancy in women with epilepsy. Lancet. 2015 Nov 7;386(10006):1804-5. 

Inoyama K, Meador KJ. Cognitive outcomes of prenatal antiepileptic drug exposure. Epilepsy Res. 2015 Aug;114:89-97. 

Baker GA, . . . Meador KJ, . . .  Liverpool and Manchester Neurodevelopment Group. IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology. 2015 Jan 27;84(4):382-90.

Meador KJ. Epilepsy: Pregnancy in women with epilepsy--risks and management. Nat Rev Neurol. 2014 Nov;10(11):614-6. 

Meador KJ, Pennell PB, May RC, Brown CA, Baker G, Bromley R, Loring DW, Cohen MJ; NEAD Investigator Group. Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study. Neurology. 2020 Feb 18;94(7):e729-e740.

Psychiatric Issues in Epilepsy

Baslet G, Bajestan SN, Aybek S, Modirrousta M, D Clin Psy JP, Cavanna A, Perez DL, Lazarow SS, Raynor G, Voon V, Ducharme S, LaFrance WC Jr. Evidence-Based Practice for the Clinical Assessment of Psychogenic Nonepileptic Seizures: A Report From the American Neuropsychiatric Association Committee on Research. J Neuropsychiatry Clin Neurosci. 2020 Aug 11:appineuropsych19120354.

Vogrig A, Hsiang JC, Ng J, Rolnick J, Cheng J, Parvizi J. A systematic study of stereotypy in epileptic seizures versus psychogenic seizure-like events. Epilepsy Behav. 2019 Jan;90:172-177.

Bajestan SN, LaFrance WC Jr. Clinical Approaches to Psychogenic Nonepileptic Seizures. Focus (Am Psychiatr Publ). 2016 Oct;14(4):422-431.

LaFrance WC Jr, Baird GL, Barry JJ, Blum AS, Frank Webb A, Keitner GI, Machan JT, Miller I, Szaflarski JP; NES Treatment Trial (NEST-T) Consortium. Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial. JAMA Psychiatry. 2014 Sep;71(9):997-1005. 

Barry JJ, Wittenberg D, Bullock KD, Michaels JB, Classen CC, Fisher RS. Group therapy for patients with psychogenic nonepileptic seizures: a pilot study. Epilepsy Behav. 2008 Nov;13(4):624-9.

Kaplan P and Fisher RS. Imitators of Epilepsy. Second Edition, Demos Press, NY, 2005.

Quality of Life in Epilepsy

Fisher RS, Nune G, Roberts SE, Cramer JA. The Personal Impact of Epilepsy Scale (PIES). Epilepsy Behav. 2015 Jan;42:140-6.

Surgical Epilepsy

Laser surgery

Huang Y, Yecies D, Bruckert L, Parker JJ, Ho AL, Kim LH, Fornoff L, Wintermark M, Porter B, Yeom KW, Halpern CH, Grant GA. Stereotactic laser ablation for completion corpus callosotomy. J Neurosurg Pediatr. 2019 Aug 2:1-9.

Le S, Ho AL, Fisher RS, Miller KJ, Henderson JM, Grant GA, Meador KJ, Halpern CH. Laser interstitial thermal therapy (LITT): Seizure outcomes for refractory mesial temporal lobe epilepsy. Epilepsy Behav. 2018 Dec;89:37-41. 

Shukla ND, Ho AL, Pendharkar AV, Sussman ES, Halpern CH. Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date. Neuropsychiatr Dis Treat. 2017 Sep 26;13:2469-2475.

Ho AL, Miller KJ, Cartmell S, Inoyama K, Fisher RS, Halpern CH. Stereotactic laser ablation of the splenium for intractable epilepsy. Epilepsy Behav Case Rep. 2016 Jan 13;5:23-6. 

New surgical methods

Cook M, Murphy M, Bulluss K, D'Souza W, Plummer C, Priest E, Williams C, Sharan A, Fisher R, Pincus S, Distad E, Anchordoquy T, Abrams D. Anti-seizure therapy with a long-term, implanted intra-cerebroventricular delivery system for drug-resistant epilepsy: A first-in-man study. EClinicalMedicine. 2020 May 3;22:100326. doi: 10.1016/ j.eclinm.2020.100326.

Fan X, Shan Y, Lu C, An Y, Wang Y, Du J, Wang D, Wei P, Fisher RS, Wang Y, Ren L, Zhao G. Optimized SEEG-guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis. Seizure. 2019 Oct;71:304-311.