Pediatric Neuro-Oncology Clinical Trials

New Diagnoses

ACNS1422

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients

ACNS1721

A Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in patients with Newly Diagnosed High-Grade Glioma (HGG) without H3 K27M or BRAFV600E Mutations

SJATRT

Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (ATRT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses ATRT

SJMB12

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Recurrent/Refractory Diseases

SJATRT

Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (ATRT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses ATRT

PBTC-049

A Phase I Study of Savolitinib in Recurrent, Progressive or Refractory Primary CNS Tumors

POE16-01

A Phase I/II Study of Neratinib in Pediatric Patients with Relapsed/ Refractory Solid Tumors or Hematologic Malignancies

ADVL1622

Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

APEC1621

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)

Ancillary Studies

APEC14B1

The Project: Everychild Protocol: A Registry, Eligibility, Screeening, Biology, and Outcome Study

ALTE07C1

Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer

NF1-OPG Natural History Study

Developing Evidence-Based Criteria for Initiating Treatment for Neurofibromatosis Type 1 Associated Optic Pathway Glioma/CTF 004: The Collection of Blood Samples from Patients With NF1 for Research Purposes

UCSC Treehouse

California Initiative to Advance Precision Medicine: California Kids Cancer Comparison, and Treehouse Childhood Cancer Initiative

For more information

To find out the current status of any study please contact us at: Neuroonc@stanfordchildrens.org