Select Multiple Sclerosis and Neuroimmunology Publications

Lawrence Steinman, MD

Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve
Neuroinflammation. Ho P,  Kanter J, Johnson AM, Srinagesh H, Chang E, Purdy TM, van Haren KP, Wikoff, WR, Kind T, Khademi M, Matloff L, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn Ok Olsson T, Han X Han MH, Steinman L and Robinson WH. Sci Transl Med 4(137):137ra73, 2012

Janus-Like Opposing Roles of CD47 in Autoimmune Brain Inflammation.
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodward JI, Brownell SE, Zoudilova M, Hunt JFV, Branzini S, Butcher E, Raine CS, Sobel RA, Han DK, Weissman I, and Steinman L. J Exp Med, 209:1325-1334, 2012

Peroxisome proliferator-activated receptors (PPAR)-α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.
Zhang MA , Rego D, Moshkova M, Kebir  H, Chruscinski  A, Nguyen HK , Akkermann R, Stanczyk FZ, Prat A, Steinman L, Dunn S. Proc Natl Acad Sci 109(24):9505-9510, 2012.

Unexpected Therapeutic Benefit from Peripheral Administration of Amyloid-β in Th1- and Th17-Versions of Experimental Autoimmune Encephalomyelitis. 
Grant JL, Bou Ghosn EE , Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Herzenberg LA, Lawrence Steinman L.  Sci Transl Med, 4: 145ra105, 2012.

The Discovery of Natalizumab, A Potent Therapeutic for Multiple Sclerosis.
Steinman L.  Journal of Cell Biology 199(3):413-6, 2012.

Piet Mondrian’s trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011 
Steinman L, Axtell RC, Barbieri D, Bhat R, Brownell S, de Jong BA, Dunn SE, Grant JL, Han MH, Ho P, Kuipers HF, Kurnellas MP, Ousman SS, and  Rothbard J. Multiple Sclerosis Journal 19:5-14, 2013.

Weighing in on Autoimmune disease: ‘Hub and Spoke’ T cell Traffic in Autoimmunity.
Steinman L.  Nature Medicine, 19:139-141, 2013.

Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Kurnellas MP, Adams CM, Sobel RA, Steinman L, Rothbard JB. Sci Transl Med. 2013; 5 (179): 179ra42

May Han, MD

Pericytes regulate vascular immune homeostasis in the CNS.  Török O, Schreiner B, Schaffenrath J, Tsai HC, Maheshwari U, Stifter SA, Welsh C, Amorim A, Sridhar S, Utz SG, Mildenberger W, Nassiri S, Delorenzi M, Aguzzi A, Han MH, Greter M, Becher B, Keller A. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). doi: 10.1073/pnas.2016587118. PubMed PMID: 33653955; PubMed Central PMCID: PMC7958247.

In-depth B cell immunophenotyping to monitor response to anti-CD20 therapy in CNS autoimmunity.  Su E, Wetzel NS, Oak J, Kipp L, Han MH.  Mult Scler Relat Disord. 2020 Nov;46:102594. doi: 10.1016/j.msard.2020.102594. Epub 2020 Oct 24. PubMed PMID: 33296989.

The impact of COVID-19 on patients with neuromyelitis optica spectrum disorder; a pilot study.  Tomczak A, Han MH. Mult Scler Relat Disord. 2020 Oct;45:102347. doi: 10.1016/j.msard.2020.102347. Epub 2020 Jun 30. PubMed PMID: 32645636.

Revealing architectural order with quantitative label-free imaging and deep learning.  Guo SM, Yeh LH, Folkesson J, Ivanov IE, Krishnan AP, Keefe MG, Hashemi E, Shin D, Chhun BB, Cho NH, Leonetti MD, Han MH, Nowakowski TJ, Mehta SB. Elife. 2020 Jul 27;9. doi: 10.7554/eLife.55502. PubMed PMID: 32716843; PubMed Central PMCID: PMC7431134.

White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis.  Planche V, Su JH, Mournet S, Saranathan M, Dousset V, Han M, Rutt BK, Tourdias T. Mult Scler. 2020 Jul;26(8):987-992. doi: 10.1177/1352458519828297. Epub 2019 Feb 7. PubMed PMID: 30730233; PubMed Central PMCID: PMC6685761.

Case series: Hearing loss in neuromyelitis optica spectrum disorders.  Tugizova M, Feng H, Tomczak A, Steenerson K, Han M. Mult Scler Relat Disord. 2020 Jun;41:102032. doi: 10.1016/j.msard.2020.102032. Epub 2020 Feb 28. PubMed PMID: 32155460.

Characterization of retinal vascular changes in multiple sclerosis using adaptive optics and OCTA. Khushzad F, Yarp J, Hargrave A, Sredar N, Mahesh V, Tomczak A, Kipp L, Han M, Dubra A, Moss H. Association for Research in Vision & Ophthalmology Annual Meeting; 2020 May 3; Baltimore, MD. Vol.61, 5104: Invest. Ophthalmol. Vis. Sci.; c2020.

Novel microscopic foveal pit pathology in multiple sclerosis revealed with adaptive optics ophthalmoscopy. Hargrave A, Sredar N, Razeen M, Khushzad F, Yarp J, Leishangthem L, Tomczak A, Kipp L, Han M, Kowalski B, Dubra A, Moss H. Association for Research in Vision & Ophthalmology Annual Meeting; 2020 May 3; Baltimore, MD. Vol.61, 5101: Invest. Ophthalmol. Vis. Sci.; c2020.

Comparison of visual function and retinal structure between phases of multiple sclerosis. Yarp J, Khushzad F, Leishangthem L, Mahesh V, Tomczak A, Han M, Kipp L, Moss H. Association for Research in Vision & Ophthalmology Annual Meeting; 2020 May 3; Baltimore, MD. Vol.61, 5103: Invest. Ophthalmol. Vis. Sci.; c2020.

Emergence of rheumatoid arthritis following exposure to natalizumab.  Su E, Novic J, Han MH. Mult Scler Relat Disord. 2020 May;40:101936. doi: 10.1016/j.msard.2020.101936. Epub 2020 Jan 16. PubMed PMID: 31982664.

Changes in immune cell profile, clinical and safety outcomes in fingolimod-treated patients with relapsing multiple sclerosis in the FLUENT study. Mao-Draayer Y, Cohen J, Bar-Or A, Han M, Singer B, Jaitly N, Kolodny S, Elam C, Meng X, Ziehn M, Cree B. American Academy of Neurology Annual Meeting; 2020 April 25; Neurology, 94 (15 Supplement) 4249; c2020.

A case of GFAP-astroglial autoimmunity presenting with reversible parkinsonism.  Tomczak A, Su E, Tugizova M, Carlson AM, Kipp LB, Feng H, Han MH. Mult Scler Relat Disord. 2019 Dec 19;39:101900. doi: 10.1016/j.msard.2019.101900. [Epub ahead of print] PubMed PMID: 31881522.

Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation.  Tsai HC, Nguyen K, Hashemi E, Engleman E, Hla T, Han MH. J Autoimmun. 2019 Dec;105:102290. doi: 10.1016/j.jaut.2019.06.001. Epub 2019 Jun 12. PubMed PMID: 31202617; NIHMSID:NIHMS1056937.

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD.  Cook LJ, Rose JW, Alvey JS, Jolley AM, Kuhn R, Marron B, Pederson M, Enriquez R, Yearley J, McKechnie S, Han MH, Tomczak AJ, Levy M, Mealy MA, Coleman J, Bennett JL, Johnson R, Barnes-Garcia M, Traboulsee AL, Carruthers RL, Lee LE, Schubert JJ, McMullen K, Kister I, Rimler Z, Reid A, Sicotte NL, Planchon SM, Cohen JA, Ivancic D, Sedlak JL, Sand IK, Repovic P, Amezcua L, Pruitt A, Amundson E, Chitnis T, Mullin DS, Klawiter EC, Russo AW, Riley CS, Onomichi KB, Levine L, Nelson KE, Nealon NM, Engel C, Kruse-Hoyer M, Marcille M, Tornes L, Rumpf A, Greer A, Kenneally Behne M, Rodriguez RR, Behne DW, Blackway DW, Coords B, Blaschke TF, Sheard J, Smith TJ, Behne JM, Yeaman MR. Neurol Neuroimmunol Neuroinflamm. 2019 Sep;6(5):e583. doi: 10.1212/NXI.0000000000000583. eCollection 2019 Sep. PubMed PMID: 31355319; PubMed Central PMCID: PMC6624150.

MR susceptibility contrast imaging using a 2D simultaneous multi-slice gradient-echo sequence at 7T.  Bian W, Kerr AB, Tranvinh E, Parivash S, Zahneisen B, Han MH, Lock CB, Goubran M, Zhu K, Rutt BK, Zeineh MM. PLoS One. 2019;14(7):e0219705. doi: 10.1371/journal.pone.0219705. eCollection 2019. PubMed PMID: 31314813; PubMed Central PMCID: PMC6636815.

Immunological Aspects of Approved MS Therapeutics.  Rommer PS, Milo R, Han MH, Satyanarayan S, Sellner J, Hauer L, Illes Z, Warnke C, Laurent S, Weber MS, Zhang Y, Stuve O. Front Immunol. 2019;10:1564. doi: 10.3389/fimmu.2019.01564. eCollection 2019. Review. PubMed PMID: 31354720; PubMed Central PMCID: PMC6637731.

The FLUENT study design: investigating immune cell subset and neurofilament changes in patients with relapsing multiple sclerosis treated with fingolimod.  Cohen JA, Bar-Or A, Cree BAC, Mao-Draayer Y, Han MH, Singer B, Jannu A, Kolodny S, Meng X, Winger RC. Mult Scler J Exp Transl Clin. 2019 Jan-Mar;5(1):2055217318819245. doi: 10.1177/2055217318819245. eCollection 2019 Jan-Mar. PubMed PMID: 30637116; PubMed Central PMCID: PMC6318720.

Molecular signature of Epstein-Barr virus infection in MS brain lesions.  Moreno MA, Or-Geva N, Aftab BT, Khanna R, Croze E, Steinman L, Han MH. Neurol Neuroimmunol Neuroinflamm. 2018 Jul;5(4):e466. doi: 10.1212/NXI.0000000000000466. eCollection 2018 Jul. PubMed PMID: 29892607; PubMed Central PMCID: PMC5994704.

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.  Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Neuron. 2017 Dec 6;96(5):1003-1012.e7. doi: 10.1016/j.neuron.2017.10.008. Epub 2017 Nov 2. PubMed PMID: 29103804; PubMed Central PMCID: PMC5851281.

Imaging B Cells in a Mouse Model of Multiple Sclerosis Using 64Cu-Rituximab PET.  James ML, Hoehne A, Mayer AT, Lechtenberg K, Moreno M, Gowrishankar G, Ilovich O, Natarajan A, Johnson EM, Nguyen J, Quach L, Han M, Buckwalter M, Chandra S, Gambhir SS. J Nucl Med. 2017 Nov;58(11):1845-1851. doi: 10.2967/jnumed.117.189597. Epub 2017 Jul 7. PubMed PMID: 28687602; PubMed Central PMCID: PMC5666646.

Integrative proteomics, genomics, and translational immunology approaches reveal mutated forms of Proteolipid Protein 1 (PLP1) and mutant-specific immune response in multiple sclerosis.  Qendro V, Bugos GA, Lundgren DH, Glynn J, Han MH, Han DK. Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600322. PubMed PMID: 28191734.

Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination.  Kuipers HF, Yoon J, van Horssen J, Han MH, Bollyky PL, Palmer TD, Steinman L. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1745-E1754. doi: 10.1073/pnas.1621314114. Epub 2017 Feb 14. PubMed PMID: 28196893; PubMed Central PMCID: PMC5338510.

Exosomal proteome analysis of cerebrospinal fluid detects biosignatures of neuromyelitis optica and multiple sclerosis.  Lee J, McKinney KQ, Pavlopoulos AJ, Han MH, Kim SH, Kim HJ, Hwang S. Clin Chim Acta. 2016 Nov 1;462:118-126. doi: 10.1016/j.cca.2016.09.001. Epub 2016 Sep 6. PubMed PMID: 27609124.

Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation.  Tsai HC, Han MH. Drugs. 2016 Jul;76(11):1067-79. doi: 10.1007/s40265-016-0603-2. Review. PubMed PMID: 27318702.

Intravenous Transplantation of Mesenchymal Progenitors Distribute Solely to the Lungs and Improve Outcomes in Cervical Spinal Cord Injury.  White SV, Czisch CE, Han MH, Plant CD, Harvey AR, Plant GW. Stem Cells. 2016 Jul;34(7):1812-25. doi: 10.1002/stem.2364. Epub 2016 Apr 4. PubMed PMID: 26989838.

Effects of sphingosine-1-phosphate receptor 1 phosphorylation in response to FTY720 during neuroinflammation.  Tsai HC, Huang Y, Garris CS, Moreno MA, Griffin CW, Han MH. JCI Insight. 2016 Jun 16;1(9):e86462. doi: 10.1172/jci.insight.86462. PubMed PMID: 27699272; PubMed Central PMCID: PMC5033897.

Jeffrey Dunn, MD

Consensus Curriculum for Fellowship Training in Multiple Sclerosis and Neuroimmunology.
Hua LH, Obeidat AZ, Amezcua L, Cohen JA, Costello K, Dunn J, Gelfand JM, Goldman MD, Hopkins S, Jeffery D, Krieger S, Newsome SD, Shah S, Sicotte NL, Yadav V, Longbrake EE. Neurol Clin Pract. 2021 Aug;11(4):352-357. doi: 10.1212/CPJ.0000000000001040. PMID: 34484933

Defining the Neuroimmunology/Multiple Sclerosis Subspecialty: Surveys of Fellowship Training in the Unites States.
Longbrake, E., Obeidat, A., Dunn, J., Sicotte, N., Hua, L. Lippincott Williams & Wilkins 2020. Web of Science # 000536058001053

Advocacy, Dissemination and Implementation Strategies for an International Standardized MRI Protocol for Diagnosis and Follow-Up of patients with Multiple Sclerosis.
Saslow, L., Li, D., Halper, J., Banwell, B., Barkhof, F., Barlow, L., Costello, K., Damiri, B., Dunn, J., Giri, S., Maes, M., Morrow, S., Newsome, S., Oh, J., Friedemann, P., Quarterman, P., Reich, D., Shewchuk, J., Shinohara, R., Van Hecke, W., Van dee Ven, K., Wallin, M., Wolinsky, J., Traboulsee, T. Int J MS Care. 2020; 22:226-232.

Consensus Curriculum for Fellowship Training in Multiple Sclerosis and Neuroimmunology.
Le H. Hua, Ahmed Obeidat, Lilyana Amezcua, Jeffrey A. Cohen, Kathleen Costello, Jeffrey Dunn, Jeffrey Gelfand, Myla Goldman, Sarah Hopkins, Douglas Jeffery, Stephen Krieger, Scott Newsome, Suma Shah, Nancy Sicotte, Vijayshree Yadav, Erin Longbrake. Neurol Clin Pract Jan 2021, 10.1212/CPJ.0000000000001040;  DOI: 10.1212/CPJ.0000000000001040

Repopulation of T, B and NK cells following alemtuzumab treatment in relapsing-remitting Multiple Sclerosis.
Gilmore, W., Lund, B., Li, P., Levy, A., Kelland, E., Akbari, O., Groshen, S., Yong, S., Pelletier, D., Weiner, L., Javed, A., Dunn, J., Traboulsee, T. Journal of Neuroinflammation 2020; 17 (1): 189

Disease Modifying Therapies for non-relapsing Multiple Sclerosis: Absence of evidence does not constitute evidence of absence.
Dunn, J. Neurol Clin Pract. December 2013; 3 (6): 515-518

Mobility Concerns in Multiple Sclerosis- Studies and Surveys on US patient populations of relevance to nurses.
Lee, J., Dunn J. US Neurology; 2013; 9(1): 17-23

Dalfampridine: A brief review of its Mechanism of Action and Efficacy as a treatment to improve walking in patients with Multiple Sclerosis.
Dunn J, Blight A. Current Research Medical Opinion. 2011; 27 (7): 1415-1423

Protective Effect of elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin olidodendrocyte glycoprotein.
Herges K, DeJong BA, Kolkowitz I, Dunn C, Mandelbaum G, Maini A, Han M, Killestein J, Polman C, Goodyear A, Dunn J, Steinman L, Axtell RC. Multiple Sclerosis. 2012; 18 (4): 398-408

The impact of mobility impairment on the burden of caregiving in individuals with multiple sclerosis
Dunn, J., Expert Rev. Pharmacoeconomics Outcomes Res.. 2010; 10 (4): 433-440

Analysis of B Cell Subsets in Multiple Sclerosis Patients on Immunomodulatory Therapy Reveals Modulation of CD19+CD24hiCD38hi Cells With Implications for the Diagnosis and Monitoring of MS
Schubert R., Goodyear A., Abraham P., Dunn C., Steinman L.; Senior authors: Dunn J. and Axtell R.: American Academy of Neurology Annual meeting abstract # P03.224;  San Diego, CA: 19 March 2013

MRI Characteristics of CNS Demyelinating Disease in Ethnic Indian Patients.
Hua, Le H., Le, Jong-mi, Dunn J.; Consortium of Multiple Sclerosis Centers CMSC Annual Conference; Montreal, Canada: 2011

CMV Optic Neuritis with Extensive Tracking along the Visual Pathway
Pershing S, Dunn J, Khan A, Liao JY, J Neuro-Ophthalmology. 2009; 29 (3): 223-226

Glatiramer Acetate after Induction Therapy with Mitoxantrone in Relapsing Multiple Sclerosis
Vollmer T, Panitch H, Bar-Or A, Dunn J, Freedman MS, Gazda SK,Campagnolo D, Deutsch F, Arnold D, Multiple Sclerosis. 2008 Apr 18

Glatiramer Acetate after Mitoxantrone Induction improves MRI markers of lesion volume and permanent tissue injury in MS
Arnold D., Campagnolo D., Panitch H., Bar-Or A., Dunn J, Freedman M., Gazda S.K., Vollmer T., J Neurol. 2008: 255 1473-1478

Lucas Kipp, MD

In-depth B cell immunophenotyping to monitor response to anti-CD20 therapy in CNS autoimmunity. Multiple sclerosis and related disordersSu, E., Wetzel, N. S., Oak, J., Kipp, L., Han, M. H.2020; 46: 102594

A case of GFAP-astroglial autoimmunity presenting with reversible parkinsonism Tomczak A, Su E, Tugizova M, Carlson AM, Kipp LB, Feng H, Han MH.  Mult Scler Relat Disord. 2019 Dec 19;39:101900. doi: 10.1016/j.msard.2019.101900. [Epub ahead of print].  PMID: 31881522 

Immunomodulatory receptors are differentially expressed in B and T cell subsets relevant to autoimmune disease Murphy KA, Bhamidiphati K, Rubin SJS, Kipp L, Robinson WH, Lanz TV. Clinical Immunology. 2019 Dec;209:108276. doi: 10.1016/j.clim.2019.108276.  PMID: 31669582

Reduced neurite density in the brain and cervical spinal cord in relapsing-remitting multiple sclerosis: A NODDI study. Collorone S, Cawley N, Grussu F, Prados F, Tona F, Calvi A, Kanber B, Schneider T, Kipp L, Zhang H, Alexander DC, Thompson AJ, Toosy A, Gandini Wheeler-Kingshott CAM, Ciccarelli O.   Mult Scler. 2019 Nov 4:1352458519885107. doi: 10.1177/1352458519885107. [Epub ahead of print].  PMID: 31682198. 

Coexistence of neuromyelitis optica and amyotrophic lateral sclerosis: Case report A Li, T McGranahan, E Su, L Kipp, C Gold.  First published in The Neurohospitalist July 5, 2018.

Autoimmune Hepatitis During Treatment of Multiple Sclerosis with Alemtuzumab. A Carlson, N Bozinov, L Kipp, J Dunn, C Lock.  [abstract & poster presentation].  Presented at: 70th American Academy of Neurology (AAN) Annual Meeting; 2018 April 21-27; Los Angeles, USA.  Published in Neurology April 9, 2018 vol. 90 no 15 supplement P5.350.

Patient reported benefits of extracranial venous therapy: British Columbia CCSVI Registry AD Sadovnick, I Yee, K Attwell-Pope, G Keyes, L Kipp, AL Traboulsee. Published in Canadian Journal of Neurological Sciences 2017; May;44(3):246-254

Neurite orientation dispersion and density imaging (NODDI) in RRMS.  L Kipp, N Cawley, F Prados, T Schneider, S Ourselin, CA Wheeler-Kingshott, DH Miller, AJ Thompson, O Ciccarelli.  [poster presentation]. Presented at:  68th American Academy of Neurology (AAN) Annual Meeting; 2016 Apr 15-21; Vancouver, Canada.  Published in Neurology April 5, 2016 vol. 86 no. 16 Supplement P4.159. 

Raymond A. Sobel, MD

Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Kurnellas MP, Adams CM, Sobel RA, Steinman L, Rothbard JB. Sci Transl Med. 2013; 5 (179): 179ra42

A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells.
Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez-Manzanet R, Greve B, Sobel RA, Kuchroo VK. J Immunol. 2012; 188 (5): 2084-92

Apparent expression of varicella-zoster virus proteins in latency resulting from reactivity of murine and rabbit antibodies with human blood group a determinants in sensory neurons.
Zerboni L, Sobel RA, Lai M, Triglia R, Steain M, Abendroth A, Arvin A. J Virol. 2012; 86 (1): 578-83

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Nat Med. 2012; 18 (9): 1394-400

Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis.
Kurnellas MP, Brownell SE, Su L, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, Schoolnik GK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L, Rothbard JB. J Biol Chem. 2012; 287 (43): 36423-34

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Proc Natl Acad Sci U S A. 2012; 109 (30): 12105-10

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. J Exp Med. 2012; 209 (7): 1325-34

Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.
Schulze-Topphoff U, Shetty A, Varrin-Doyer M, Molnarfi N, Sagan SA, Sobel RA, Nelson PA, Zamvil SS. PLoS One. 2012; 7 (3): e33797

Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.
Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. Mol Biol Cell. 2011; 22 (2): 256-65

Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation.
Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Immunity. 2011; 35 (6): 986-96

Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.
Crespo O, Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH. J Clin Immunol. 2011; 31 (6): 1010-20

Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin.
Kim A, Joseph S, Khan A, Epstein CJ, Sobel R, Huang TT. Free Radic Biol Med. 2010; 48 (11): 1501-12

Expression of varicella-zoster virus immediate-early regulatory protein IE63 in neurons of latently infected human sensory ganglia.
Zerboni L, Sobel RA, Ramachandran V, Rajamani J, Ruyechan W, Abendroth A, Arvin A. J Virol. 2010; 84 (7): 3421-30

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity.
Dunn SE, Bhat R, Straus DS, Sobel RA, Axtell R, Johnson A, Nguyen K, Mukundan L, Moshkova M, Dugas JC, Chawla A, Steinman L. J Exp Med. 2010; 207 (8): 1599-608

Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells.
Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. J Immunol. 2010; 185 (3): 1383-92

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.
Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L. Proc Natl Acad Sci U S A. 2009; 106 (35): 14948-53

Keith P. Van Haren, MD

Case Report of Subdural Hematoma in a Patient With Sturge-Weber Syndrome and Literature Review: Questions and Implications for Therapy
Lopez J., Yeom K. W., Comi A., Van Haren K. 2013; 28 (5): 672-675

Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation
Ho P. P., Kanter J. L., Johnson A. M., Srinagesh H. K., Chang E., Purdy T. M., Van Haren K., Wikoff W. R., Kind T., Khademi M., Matloff L. Y., Narayana S., Hur E. M., Lindstrom T. M., He Z., Fiehn O., Olsson T., Han X., Han M. H., Steinman L., Robinson W. H. 2012; 4 (137)

Therapeutic Advances in Pediatric Multiple Sclerosis.
The Journal of pediatrics Van Haren K., Waubant E. 2013 Multiple Sclerosis Journal; 19 (13): 1726-1733

Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) Van Haren K., Tomooka B. H., Kidd B. A., Banwell B., Bar-Or A., Chitnis T., Tenembaum S. N., Pohl D., Rostasy K., Dale R. C., O'Connor K. C., Hafler D. A., Steinman L., Robinson W. H. 2013

Les Dorfman, MD

Neurocognitive impairment in adults with moyamoya disease without stroke.
Karzmark P, Zeifert PD, Bell-Stephens TE, Steinberg GK, Dorfman LJ. Neurosurgery. 2012; 70 (3): 634-8

Neuroradiologic correlates of cognitive impairment in adult Moyamoya disease.
Mogensen MA, Karzmark P, Zeifert PD, Rosenberg J, Marks M, Steinberg GK, Dorfman LJ. AJNR Am J Neuroradiol. 2012; 33 (4): 721-5

Y. Joyce Liao, MD, PhD

Plasticity and stability of the visual system in human a chiasma
Hoffman MB, Kaule FR, Levin N, Masuda Y, Kimar N, Gottlob I, Horiguchi H, Dougherty RF, Stadler J, Wolynski B, Speck O, Kanowski M, Liao YJ, Wandell BA, Dumoulin SO. Neuron. 2012

Functional rescue of experimental ischemic optic neuropathy with αB-crystallin.
Pangratz-Fuehrer S, Kaur K, Ousman SS, Steinman L, Liao YJ. Eye (Lond). 2011; 25 (6): 809-17

Junctional visual field loss in a case of Wyburn-Mason syndrome.
Liu A, Chen YW, Chang S, Liao YJ. J Neuroophthalmol. 2012; 32 (1): 42-4

The immunopathology of giant cell arteritis: diagnostic and therapeutic implications.
Weyand CM, Liao YJ, Goronzy JJ. J Neuroophthalmol. 2012; 32 (3): 259-65

Dorsolateral midbrain MRI abnormalities and ocular motor deficits following cytarabine-based chemotherapy for acute myelogenous leukemia.
Doan T, Lacayo N, Fisher PG, Liao YJ. J Neuroophthalmol. 2011; 31 (1): 52-3

Giant cell arteritis: immune and vascular aging as disease risk factors.
Mohan SV, Liao YJ, Kim JW, Goronzy JJ, Weyand CM. Arthritis Res Ther. 2011; 13 (4): 231

Congenital achiasma and see-saw nystagmus in VACTERL syndrome.
Prakash S, Dumoulin SO, Fischbein N, Wandell BA, Liao YJ. J Neuroophthalmol. 2010; 30 (1): 45-8

Christopher Lock, MBBS, PhD

MR susceptibility contrast imaging using a 2D simultaneous multi-slice gradient-echo sequence at 7T.
Bian W, Kerr AB, Tranvinh E, Parivash S, Zahneisen B, Han MH, Lock CB, Goubran M, Zhu K, Rutt BK, Zeineh MM.  PLoS One.2019;14(7):e0219705. doi:10.1371/journal.pone.0219705. eCollection 2019. PubMed PMID: 31314813; PubMed Central PMCID: PMC6636815.

Clonally Expanded B Cells in Multiple Sclerosis Bind EBV and GlialCAM.
Lanz TB, Brewer RC, Ho PP, Jude KM, Fernandez D, Fernandes RA, Gomez A, Nadj G, Schubert RD, Teegen B, Dunn JE, Lock CB, Kipp LB, Cotham VC, Ueberheide BM, Aftab BT, Wilson MR, Bashford-Rogers RJM, Platen M, Sobel RA, Garcia CK, Steinman L, Robinson WH. Nature 603, 321–327 (2022). 

A variant of uncertain significance in SDHAF1, the succinate dehydrogenase chaperone protein, in an adult patient with spastic paraparesis and leukoencephalopathy.
Vlahovic L, Lock CB, Han MH, Vann Haren K, Sampson JB. Mult Scler Relat Dis. July 03, 2021

Heerfordt's syndrome with polyradiculopathy, a rare presentation of neurosarcoidosis: Case report and review of literature.
Wu D, Sattarnezhad N, Dujari S, Lock CB, Han M. Neuroimmunology Reports,Volume 2,2022,100087, ISSN 2667-257X

Evaluation of neurotrophic factor secreting mesenchymal stem cells in progressive multiple sclerosis.
Cohen JA, Lublin FD, Lock C, Pelletier D, Chitnis T, Mehra M, Gothelf Y, Aricha R, Lindborg S, Lebovits C, Levy Y, Motamed Khorasani A, Kern R. Mult Scler. 2022 Sep 14:13524585221122156. doi: 10.1177/13524585221122156. PMID: 36113170

Protein-ligand binding free energy calculations with ARROW: a purely first principal parameterized polarizable force field.
Nawrocki G, Leontyev I, Sakipov S, Darkhovskiy M, Kurnikov I, Pereyaslavets L, Kamath G, Voronina E, Butin O, Illarionov A, Olevanov M, Kostikov A, Ivahnenko I, Patel D, Sankaranarayanan S, Kurnikova M, Lock C, Crooks G, Levitt M, Kornberg R, Fain B. Journal of Chemical Theory and Computation 2022, 18, 12, 7751-7763 (Biomolecular Systems) Publication Date (Web): December 2, 2022 DOI: 10.1021/acs.jctc.2c00930

Progression of mycosis fungoides following fingolimod treatment for multiple sclerosis and targeted next generation sequencing demonstrating potential links between the two diseases.
Narala S, Che Y, Saleem A, Lock CB, Kim YH, Rieger KE. JCO Precis Oncol. 2023 Feb;7:e2200501. doi: 10.1200/PO.22.00501. PMID: 36724412

Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity.
Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A.  Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2207291120. doi: 10.1073/pnas.2207291120. Epub 2023 Jan 12. PMID: 36634138

Identification of Novel CSF Measures of Disease Activity and Progression in MS: Results of the Ocrelizumab Biomarker Outcomes Evaluation Study (OBOE) An Open-Label Clinical Trial in Relapsing and Primary Progressive MS
Anne H. Cross, Jeffrey M. Gelfand, Simon Thebault, Jeffrey L. Bennett, H. Christian von Büdingen, Briana Cameron, Robert Carruthers, Keith Edwards, Robert Fallis, Rachel Gerstein, Paul S. Giacomini, Benjamin Greenberg, David A. Hafler, Carolina Ionete, Ulrike W. Kaunzner, Lay Kodama, Christopher Lock, MD, Erin E. Longbrake, Bruno Musch, Gabriel Pardo, Fredrik Piehl, Martin S. Weber, Steven Yuen, Tjalf Ziemssen, MD, Gauruv Bose, Mark S. Freedman, Veronica G. Anania, Akshaya Ramesh, Ryan C. Winger, Xiaoming Jia, Ann Herman, Christopher Harp, Amit Bar-Or . JAMA Neurology, 2023 submitted

Prevalence, Demographic and Clinical Factors Associated with Cognitive Dysfunction in Patients with Neuromyelitis Optica Spectrum Disorder.
Vlahovic L, et al.  Neurology 2023 (in press)

Combining Force Fields and Neural Networks for an Accurate Representation of Chemically Diverse Interactions.
Illarionov A, Sakipov S, Pereyaslavets L, Kurnikov I, Kamath G, Butin O, Voronina E, Ivahnenko I, Leontyev I, Nawrocki G, Darkhovskiy M, Olevanov M, Cherniavskyi YK, Lock C, Greenslade S, Sankaranarayanan S, Kurnikova M, Potoff J, Kornberg R, Levitt M, Fain B. J. Am. Chem. Soc. 2023, 145, 43, 23620–23629