The Stanford Neuro-Oncology Program Adult Clinical Trials

Newly Diagnosed Glioma

A Follow-Up Study to Add Whole Brain Radiotherapy (WBRT) to Standard Temozolomide Chemo-Radiotherapy in Newly Diagnosed Glioblastoma (GBM) Treated with 4 Weeks of Continuous Infusion Plerixafor
PI: Lawrence Recht, MD
Co-PI: Reena Thomas, MD PhD
Clinicaltrials.gov#: NCT03746080

A Phase I Study of Tumor Treating Fields with 5-Day Hypofractionated Stereotactic Radiosurgery and Concurrent and Maintenance Temozolomide in Newly Diagnosed Glioblastoma
PI: Scott Soltys, MD
Clinicaltrials.gov#: NCT04474353

Pivotal, Randomized, Open-label Study of Optune (Tumor Treating Fields) Concomitant with RT & TMZ for the Treatment of Newly Diagnosed GBM (EF-32)
PI: Seema Nagpal, MD
Clinicaltrials.gov#: NCT04471844

Recurrent High Grade Glioma

ONC201 in Adults With Recurrent H3 K27M-mutant Glioma
PI: Reena Thomas, MD PhD
ClinicalTrials.gov#: NCT03295396

Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM
PI: Micheal Lim, MD
ClinicalTrials.gov#: NCT03961971

Assessment of Safety and Feasibility of Exablate Type 2 Blood-Brain Barrier Disruption (BBBD) with Microbubble Resonators for the Treatment of Recurrent Glioblastoma (rGBM) in Subjects Undergoing Carboplatin Monotherapy
PI: Seema Nagpal, MD
ClinicalTrials.gov#: NCT04417088

TTAC-0001 Phase II Trial With Recurrent Glioblastoma Progressed on Bevacizumab
PI: Seema Nagpal
ClinicalTrials.gov#: NCT03856099

Recurrent Low Grade Glioma

Study of AG-881 in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)
PI: Seema Nagpal, MD
Clinicaltrials.gov#: NCT04164901

CNS Diagnostic Imaging

Phase I/II, Open-Label Study Evaluating the Efficacy and Pharmacokinetics of Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Neoplasms during Neurosurgical Procedure
PI: Gordon Li, MD
Clinicaltrials.gov#: NCT03510208

A Phase I Study of [18F]DASA-23 as a PET Tracer for Evaluating Pyruvate Kinase M2 (PKM2) Expression in Healthy Volunteers and in Patients with Intracranial Tumors
PI: Guido Davidzon, MD SM
Clinicaltrials.gov#: NCT03539731

A Pilot Study to Assess Lactate and Bicarbonate Detection Within Malignant Brain Tumors Using [1-13C]-Pyruvate DNP Magnetic Resonance Spectroscopy (MRS)
PI: Lawrence Recht, MD
Clinicaltrials.gov#: NCT03565367