The Stanford Neuro-Oncology Program Adult Clinical Trials

Newly Diagnosed Glioma

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Optune® (TTFields, 200 kHz) concomitant with Maintenance Temozolomide and Pembrolizumab Versus Optune® Concomitant with Maintenance Temozolomide and Placebo for the Treatment of Newly Diagnosed Glioblastoma (EF-41/KEYNOTE D58)
PI: Lawrence Recht, MD
Research Coordinator: Sahara Rout
Contact: ssrout@stanford.edu
ClinicalTrials.gov#: NCT06556563
 

Recurrent High Grade Glioma

Phase I Clinical Trial of Locoregionally (LR) Delivered Autologous B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Adults with Recurrent Glioblastoma Multiforme (GBM)
PI: Reena Thomas, MD PhD
ClinicalTrials.gov#: NCT05474378

A Randomized Surgical Window of Opportunity Study with Dose Escalation to Evaluate Whether Oral Fluoxetine Can Induce Cytotoxic Lysosomal Stress and Enhance Temozolomide Efficacy in Clinical Glioma (The FLIrT Trial)
PI: Seema Nagpal, MD
ClinicalTrials.gov#: NCT05634707

A Phase I Study of Multiple Doses of Neural Stem Cell-Based Oncolytic Virotherapy (NSC-CRAd-S-pk7) Administered Intracerebrally to Patients with Recurrent High Grade Gliomas
PI: Melanie Hayden Gephart, MD
ClinicalTrials.gov#: NCT05139056
 

H3K27M Mutant Glioma

Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2CART) for Diffuse Intrinsic Pontine Gliomas (DIPG) and Spinal Diffuse Midline Glioma (DMG)
PI: Michelle Monje, MD PhD
ClinicalTrials.gov #: NCT04196413
 

Brain and Spine Metastases 

A Randomized Phase III TriaL Comparing SingLe- Versus Multi-Fraction Spine STereotActic Radiosurgery for Patients with Spinal Metastases (ALL-STAR)
PI: Erqi Pollum, MD
ClinicalTrials.gov#: NCT06173401