The Stanford Neuro-Oncology Program Adult Clinical Trials

Newly Diagnosed Glioma

A Phase I Study of Tumor Treating Fields with 5-Day Hypofractionated Stereotactic Radiosurgery and Concurrent and Maintenance Temozolomide in Newly Diagnosed Glioblastoma
PI: Scott Soltys, MD
ClinicalTrials.gov#: NCT04474353

A Phase II Study of BPM31510 with Vitamin K1 in Subjects with Newly Diagnosed Glioblastoma (GB)
PI: Seema Nagpal, MD
ClinicalTrials.gov#: NCT04752813

Pivotal, Randomized, Open-label Study of Optune (Tumor Treating Fields) Concomitant with RT & TMZ for the Treatment of Newly Diagnosed GBM (EF-32)
PI: Seema Nagpal, MD
ClinicalTrials.gov#: NCT04471844

Recurrent High Grade Glioma

ONC201 in Adults With Recurrent H3 K27M-mutant Glioma
PI: Reena Thomas, MD PhD
ClinicalTrials.gov#: NCT03295396

Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM
PI: Michael Lim, MD
ClinicalTrials.gov#: NCT03961971

TTAC-0001 Phase II Trial With Recurrent Glioblastoma Progressed on Bevacizumab
PI: Seema Nagpal, MD
ClinicalTrials.gov#: NCT03856099

BRAF V600 Mutations

A Phase I, First-In-Human, Multicenter, Open-Label Study of ABM-1310, Administered Orally in Adult Patients with Advanced Solid Tumors
PI: Seema Nagpal, MD
ClinicalTrials.gov#: NCT04190628

NTRK-Fusion Positive

CNS Diagnostic Imaging

A Phase I Study of [18F]DASA-23 as a PET Tracer for Evaluating Pyruvate Kinase M2 (PKM2) Expression in Healthy Volunteers and in Patients with Intracranial Tumors
PI: Guido Davidzon, MD SM
ClinicalTrials.gov#: NCT03539731