Child Neuro Studies

Pediatric Epilepsy and Seizures

Sunflower Syndrome - Self-Induced Photosensitive Epilepsy
PI: Fiona Baumer, MD

Epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS): a review of current treatment practices
PI: Fiona Baumer, MD

Cortical Excitability, Synaptic Plasticity and Learning in Benign Epilepsy with Centrotemporal Spikes (BECTS)
PI: Fiona Baumer, MD

Consortium for Standardizing TMS (Transcranial Mangetic Stimulation) Language Mapping Protocols and Establishing Best Practice Guidelines for Using TMS in Presurgical Evaluation of Language in Children
PI: Fiona Baumer, MD

Consequences of Prolonged Febrile Seizures in Childhood
PI: William Gallentine, DO

Novel Early Imaging Markers Following Febrile Status Epilepticus
PI: William Gallentine, DO

Open-Label Safety and Efficacy Study of Cenobamate (YKP3089) in Pediatric Subjects with Partial-onset (Focal) Seizures
PI: William Gallentine, DO

Brain Connectivity Changes in Benign Epilepsy with Centrotemporal Spikes and other Pediatric Epilepsy Syndromes
PI: Fiona Baumer, MD

Diagnostic, Prognostic, and Therapeutic Applications of TMS for Epilepsy
PI: Fiona Baumer, MD

A Multi-Center Examination of Pediatric Epilepsy Surgery Evaluation in the US
PI: Ann Hyslop, MD

Investigation of Keto-Amino Acids as Novel Therapeutics for Refractory Pediatric Epilepsy
PI: Juliet Knowles, MD, PhD

A Randomized, Double-Blind, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Carisbamate (YKP509) As Adjunctive Treatment For Seizures Associated With Lennox-Gastaut Syndrome In Children And Adults, With Optional Open-Label Extension (SK-LGS)
PI: Brenda Porter, MD, PhD

Children with Lennox-Gastaut Syndrome (LGS) treated with Deep Brain Stimulation (DBS)
PI: Juliet Knowles, MD, PhD

White matter structure and function in children with Lennox-Gastaut Syndrome
PI: Juliet Knowles, MD, PhD

A Multimodal Biomarker-based Predictive Model for Infantile Spasms
PI: Ann Hyslop, MD

PERF Genetic Epilepsy Registry
PI: Juliet Knowles, MD, PhD

MRI Microstructure Mapping to Improve Detection of Focal Cortical Dysplasia
PI: Juliet Knowles, MD, PhD

Study of Oral MC-1 for the Treatment of Patients with PNPO Deficiency
PI: Courtney Wusthoff, MD

Neurogenetic disorders

A Natural History Study of Rare Neurogenetic Disorders
PI: Rebecca Levy, MD, PhD

A Retrospective Case Series of Timothy Syndrome
PI: Rebecca Levy, MD, PhD

SLC13A5 Deficiency:A Prospective Natural History Study
PI: Brenda Porter, MD, PhD

Tuberous Sclerosis Complex

Pediatric Epilepsy Surgery: Decision-Making Survey in Patients with Tuberous Sclerosis
PI: Brenda Porter, MD, PhD

Preventing Epilepsy Using Vigabatrin in Infants with Tuberous Sclerosis Complex (PREVeNT Trial)
PI: Brenda Porter, MD, PhD

Stopping Tuberous Sclerosis Complex Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study (TSC-STEPS)
PI: Brenda Porter, MD, PhD

Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)
PI: Brenda Porter, MD, PhD

Pediatric neuroinflammatory disorders

Project BIG: The Stanford Brain Immune Gut Research Initiative
PI: Keith Van Haren, MD

Biobank for Neuroinflammatory Disorders
PI: Keith Van Haren, MD

Leukodystrophy

A phase 1-3, Double Bind, Randomized Placebo- Controlled Study to Evaluate the Efficacy, Safety, PharmacoKinetics and Pharmacodynamics Intrathecally Administered ION373 in Patients with Alexander Disease (Gene Transfer)
PI: Keith Van Haren, MD

A phase 3 Study of Lenti-D Drug Product After Myeloblative Conditioning Using Busulfan and Fludarabine in Subjetcs 17 Years of Age and Under With Cerebral Adrenoleukodystrophy (CALD) (BMT/GeneTransfer)
PI: Keith Van Haren, MD

The Effect of Vitamin D3 on Markers of Oxidative Stress in Boys with X-Linked Adrenoleukodystrophy (ALD)
PI: Keith Van Haren, MD

New Diagnostic Approaches in Leukodystrophy - The Myelin Disorders Biorepository and Natural History Project
PI: Keith Van Haren, MD

Multiple Sclerosis

Continuation of the analysis of Cytokine Modulation with Tecfidera in Human Immune Cell Subsets using High Dimensional Flow Cytometry and CYTOF Mass Spectrometry
PI: Lawrence Steinman, MD

Single Cell RNA-seq and CITE-seq on B cells in the peripheral blood and CSF of MS patients prior and during therapy with ATA-188
PI: Lawrence Steinman, MD

Neonatal Neurology

Neonatal Seizure Registry
PI: Courtney Wusthoff, MD

High Frequency Oscillations in Neonates
PI: Courtney Wusthoff, MD

Neonatal Seizure Registry- Developmental functional Evaluation (NSR-DEV)
PI: Courtney Wusthoff, MD

Continued Anticonvulsants After Resolution of Neonatal Seizures: A Patient-centered Comparative Effectiveness Study
PI: Courtney Wusthoff, MD

Temporal-spatial quantification of neonatal seizure burden caused by arterial ischemic stroke
PI: Courtney Wusthoff, MD

MRI and EEG findings in preterm neonates with HIE
PI: Courtney Wusthoff, MD

Childhood Stroke

Vascular Effects of Infection in Pediatric Stroke (VIPS II) Study
PI: Sarah Lee, MD

Stanford Children's Health Pediatric Stroke Database
PI: Sarah Lee, MD

International Pediatric Stroke Registry: Risk Factors and Outcome Observational Study
PI: Sarah Lee, MD

Seizures and Children 's Outcomes after Stroke (SCOUTS)
PI: Sarah Lee, MD

Leducq Trans-Atlantic Network of Excellence On Circadian Effects in Stroke (CIRCA-Stroke)
PI: Sarah Lee, MD

Focal Cerebral Arteriopathy Steroid Trial Pediatric Comparative Effectiveness Trial (FOCAS)
PI: Sarah Lee, MD

acutE Perfusion Imaging in Childhood LVO (EPIC-LVO): A Prospective Neuroimaging Pilot Study
PI: Sarah Lee, MD

Pediatric Neurocritical Care

Practices in the Evaluation of Pediatric Brain Death
PI: Courtney Wusthoff, MD

Critical Care EEG Monitoring Research Consortium
PI: Courtney Wusthoff, MD

Creation and Development of Pediatric Neurocritical Care Database
PI: Courtney Wusthoff, MD

Neurofibromatosis Type 1 (NF1)

MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas
PI: Cynthia Campen, MD

A Phase 2b Trial of MEK ½ Inhibitor (MEKi) PD-0325901 in Adult and Pediatric Patients with Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs) that are Causing Significant Morbidity
PI: Cynthia Campen, MD

Developing Evidence-Based Criteria for Initiating Treatment for NF1-Associated Optic Pathway Glioma:  A Natural History Observational Study
PI: Cynthia Campen, MD

Neuroimaging Correlates of Neurocognitive Deficits in Children with NF1
PI: Cynthia Campen, MD

Optic disc drusen

Optic Disc Drusen in children
PI: Shannon Beres, MD

For more information

To find out the current status of any pediatric study please contact us: arushi.gehani@stanford.edu