Stanford Neurohospitalist Division Research

The Stanford Neurohospitalist Service participates in a number of ongoing clinical trials in collaboration with other departments and divisions at Stanford, including Neuro-oncology, Neuromuscular, Neuroimmunology, Bone Marrow Transplant and the Cancer Cell Therapy Program:

Chimeric Antigen Receptor T (CAR T) Cell Therapy

1. B7H3 CAR T Cells in Recurrent Glioblastoma Multiforme
2. GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma (DMG)  
3. Anti-CD19 CAR T Cells in Non-Relapsing Multiple Sclerosis
4. Anti-CD19 CAR T Cells in Refractory Generalized Myasthenia Gravis

Anti-Sense Oligonucleotide (ASO) Therapy

1. FREEDOM: ASO therapy for Myotonic Dystrophy type 1
2. Fortitude: ASO therapy for Facioscapulohumeral Muscular Dystrophy
3. ASCEND: ASO therapy for Spinal Muscular Atrophy

Other Biologic Therapies

1. Brainshuttle: Subcutaneous R07121932 therapy for Multiple Sclerosis
2. BEAT-MS: A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-resistant Relapsing Multiple Sclerosis

Ruff IM, de Havenon A, Bergman DL, Dugue R, Frontera JA, Goldstein JN, Hemphill JC, Marulanda-Londono E, Prabhakaran S, Richards CT, Sunmonu NA, Vilar P, Wolfe SQ. 2024 AHA/ASA Performance and Quality Measures for Spontaneous Intracerebral Hemorrhage: A Report From the American Heart Association/American Stroke Association. Stroke. 2024 May 2.  

Dujari S, Wei J, Kraler L, Goyal T, Bernier E, Schwartz N, Hirsch K, Gold CA. Inpatient Neurology Deaths and Factors Associated With Discharge to Hospice. Neurohospitalist. 2023 Oct;13(4):337-344.

Kvam KA, Benatar M, Brownlee A, Caller T, Das RR, Green P, Kolodziejczak S, Russo J, Sanders D, Sethi N, Stavros K, Stierwalt J, Giles Walters N, Bennett A, Wessels SR, Brooks BR. Amyotrophic Lateral Sclerosis Quality Measurement Set 2022 Update: Quality Improvement in Neurology. Neurology. 2023 Aug 1;101(5):223-232.

Lyman KA, Madill E, Thatikunta P, Threlkeld ZD, Banaei N, Gold CA. An Electronic Health Record Intervention to Limit Viral Testing of Cerebrospinal Fluid. Neurohospitalist. 2023 Apr;13(2):173-177.

Vilendrer S, Levoy E, Miller-Kuhlmann R, Amano A, Brown-Johnson C, De Borba L, Luu JH, Sakamuri S, Gold CA. Physician Perceptions of Performance Feedback and Impact on Personal Well-Being: A Qualitative Exploration of Patient Satisfaction Feedback in Neurology. Jt Comm J Qual Patient Saf. 2023 Mar;49(3):138-148.

Lerner DP, Tadevosyan A, Scott BJ, Ramineni A, Bassil R, Burns JD, Russell JA. Single institution experience with death by neurological criteria/brain death guideline adherence. J Clin Neurosci. 2023 Feb;108:25-29.

Gold CA, Scott BJ, Weng Y, Bernier E, Kvam KA. Outcomes of a Neurohospitalist Program at an Academic Medical Center. Neurohospitalist. 2022 Jul;12(3):453-462.

Kvam KA, Bernier E, Gold CA. Quality Improvement Metrics and Methods for Neurohospitalists. Neurol Clin. 2022 Feb;40(1):211-230.

Kling SMR, Falco-Walter JJ, Saliba-Gustafsson EA, Garvert DW, Brown-Johnson CG, Miller-Kuhlmann R, Shaw JG, Asch SM, Yang L, Gold CA, Winget M. Patient and Clinician Perspectives of New and Return Ambulatory Teleneurology Visits. Neurol Clin Pract. 2021 Dec;11(6):472-483.

Goyal T, Probasco JC, Gold CA, Klein JP, Weathered NR, Thakur KT. Neurohospitalist Practice and Well-Being During the COVID-19 Pandemic. Neurohospitalist. 2021 Oct;11(4):333-341.

Rice DR, Kaplan TB, Hotan GC, Vogel AC, Matiello M, Gillani RL, Hutto SK, Ham AS, Klawiter EC, George IC, Galetta K, Mateen FJ. Electronic pill bottles to monitor and promote medication adherence for people with multiple sclerosis: A randomized, virtual clinical trial. J Neurol Sci. 2021 Sep 15

Dujari S, Gummidipundi S, He Z, Gold CA. Administration of Dexamethasone for Bacterial Meningitis: An Unreliable Quality Measure. Neurohospitalist. 2021 Apr;11(2):101-106.

Saliba-Gustafsson EA, Miller-Kuhlmann R, Kling SMR, Garvert DW, Brown-Johnson CG, Lestoquoy AS, Verano MR, Yang L, Falco-Walter J, Shaw JG, Asch SM, Gold CA, Winget M. Rapid Implementation of Video Visits in Neurology During COVID-19: Mixed Methods Evaluation. J Med Internet Res. 2020 Dec 9;22(12)

Lamsam L, Bhambhvani HP, Ratliff JK, Kvam KA. Emergent neuroimaging for seizures in epilepsy: A population study. Epilepsy Behav. 2020 Nov;112:107339.

Yang L, Brown-Johnson CG, Miller-Kuhlmann R, Kling SMR, Saliba-Gustafsson EA, Shaw JG, Gold CA, Winget M. Accelerated launch of video visits in ambulatory neurology during COVID-19: Key lessons from the Stanford experience. Neurology. 2020 Aug 18;95(7):305-311.

Murray NM, Joshi AN, Kronfeld K, Hobbs K, Bernier E, Hirsch KG, Gold CA. A Standardized Checklist Improves the Transfer of Stroke Patients from the Neurocritical Care Unit to Hospital Ward. Neurohospitalist. 2020 Apr;10(2):100-108.

Kvam KA, Douglas VC, Whetstone WD, Josephson SA, Betjemann JP. Yield of Emergent CT in Patients With Epilepsy Presenting With a Seizure. Neurohospitalist. 2019 Apr;9(2):71-78.

Culbertson CJ, Gold CA. Expanding Access to Magnetic Resonance Imaging for Patients With Cardiac Rhythm Devices. JAMA Neurol. 2018 Oct 1;75(10):1173-1174.

Xiong K, Miller-Kuhlmann RK, Scott BJ, He Z, Dujari S, Gold C, Kvam KA.  Education Research: Sustained Implementation of Quality Improvement Practices Is Observed in Early Career Physicians Following a Neurology Resident QI Curriculum.Neurology Education 2024;3:e200137. 

Dujari S, Scott BJ, Gold CA, Weng Y, Kvam KA. Education Research: Educational Outcomes Associated With the Introduction of a Neurohospitalist Program. Neurology Education 2024;3:e200131.

Gold CA, Jensen R, Sasnal M, Day HS, Miller-Kuhlmann RK, Blankenburg RL, Rassbach CE, Morris AM, Korndorffer JR Jr, Nassar AK. Impact of a coaching program on resident perceptions of communication confidence and feedback quality. BMC Med Educ. 2024 Apr 22;24(1):435.  

Chen A, Prasad S, Bowley M, Krupat E, Galetta K. Perception of In-Person Prerounding Amongst Neurology Residents Across Two Academic Centers. Neurohospitalist. 2024 Apr;14(2):140-146.  

Selling, S.K., Kirkey, D., Goyal, T., Singh, A., Gold, C.A., Hilgenberg, S.L., Weimer-Elder, B., Kuo, K.W. and Rassbach, C.E., 2022. Impact of a relationship-centered care communication curriculum on pediatric residents’ practice, perspectives, and opportunities to develop expertise. Patient Education and Counseling, 105(5), pp.1290-1297.

Galetta K, Meltzer E. Does GPT-4 have neurophobia? Localization and diagnostic accuracy of an artificial intelligence-powered chatbot in clinical vignettes. J Neurol Sci. 2023 Oct 15;453:120804.

Goyal T, Bereknyei Merrell S, Weimer-Elder B, Kline M, Rassbach CE, Gold CA. A Novel Serious Illness Communication Curriculum Improves Neurology Residents' Confidence and Skills. J Palliat Med. 2023 Sep;26(9):1180-1187.

Nassar AK, Sasnal M, Miller-Kuhlmann RK, Jensen RM, Blankenburg RL, Rassbach CE, Smith-Bentley M, Vyas A, Korndorffer JR, Gold CA. Developing a multi-departmental residency communication coaching program. Educ Health (Abingdon). 2022 Sep-Dec;35(3):98-104.

Sasnal M, Miller-Kuhlmann R, Merrell SB, Beres S, Kipp L, Lee S, Threlkeld Z, Nassar AK, Gold CA. Feasibility and acceptability of virtually coaching residents on communication skills: a pilot study. BMC Med Educ. 2021 Sep 29;21(1):513

Miller-Kuhlmann R, Kraler L, Bozinov N, Frolov A, Mlynash M, Gold CA, Kvam KA. Education Research: A novel resident-driven neurology quality improvement curriculum. Neurology. 2020 Jan 21;94(3):137-142.

Zheng J, Gold CA. Eponyms are here to stay: Usage in the literature and among current neurology trainees. Neurology. 2020 Feb 11;94(6):257-264.

Goyal T, Hasty BN, Bereknyei Merrell S, Gold CA. Education Research: Understanding barriers to goals of care communication for neurology trainees. Neurology. 2019 Aug 20;93(8):362-366.

Galetta K, Ham AS, Vishnevetsky A, Bhattacharyya S, Mateen FJ. Disease modifying therapy in the treatment of tumefactive multiple sclerosis: A retrospective cohort study. J Neuroimmunol. 2024 Mar 15;388:578299. doi: 10.1016/j.jneuroim.2024.578299. Epub 2024 Feb 1. PMID: 38364529.

Silverman A, Dugue R, George PM. Clinical Problem Solving: A 38-year-Old Woman With Systemic Lupus Erythematosus Presenting With Headache, Nausea, and Vomiting. Neurohospitalist. 2023 Oct;13(4):394-398. doi: 10.1177/19418744231182285. Epub 2023 Jun 8.

Oetjen LK, Bhattacharyya S, Galetta K. MYD88 L265P mutation in neurologic autoimmunity without evidence of malignancy. Mult Scler Relat Disord. 2023 Sep;77:104868.

Conway S, Saxena S, Baecher-Allan C, Krishnan R, Houtchens M, Glanz B, Saraceno TJ, Polgar-Turcsanyi M, Bose G, Bakshi R, Bhattacharyya S, Galetta K, Kaplan T, Severson C, Singhal T, Stazzone L, Zurawski J, Paul A, Weiner HL, Healy BC, Chitnis T. Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine. Mult Scler J Exp Transl Clin. 2023 Apr 5;9(2)

Conway SE, Pua DKA, Holroyd KB, Galetta K, Bhattacharyya S. Neurologic disease activity in people with multiple sclerosis treated with immune checkpoint inhibitors. Mult Scler. 2023 Mar;29(3):471-474.

Galetta K, Ryan S, Manzano G, Chibnik LB, Balaban D, Prasad S, Chwalisz BK, Salazar-Camelo A, Conway S, Levy M, Matiello M. Treatment outcomes of first-ever episode of severe optic neuritis. Mult Scler Relat Disord. 2022 Oct;66:104020. doi: 10.1016/j.msard.2022.104020. Epub 2022 Jul 2.

Howard D, Galetta K. Rethinking the algorithm for fatigue management in MS-how the placebo effect can confound clinical expertise. Mult Scler Relat Disord. 2022 Sep;65:104021.

Conway SE, Healy BC, Zurawski J, Severson C, Kaplan T, Stazzone L, Galetta K, Chitnis T, Houtchens MK. COVID-19 severity is associated with worsened neurological outcomes in multiple sclerosis and related disorders. Mult Scler Relat Disord. 2022 Jul;63:103946.

Manzano GS, Holroyd KB, Kaplan T, Bhattacharyya S, Chitnis T, Hotan G, Zurawski J, Galetta KM, Mateen FJ. Disease modifying therapy management of multiple sclerosis after stem cell therapies: A retrospective case series. Mult Scler Relat Disord. 2022 Jul;63:103861.

Galetta K, Deshpande C, Healy BC, Glanz B, Ziehn M, Saxena S, Paul A, Saleh F, Collins M, Gaitan-Walsh P, Castro-Mendoza P, Weiner HL, Chitnis T. Serum neurofilament levels and patient-reported outcomes in multiple sclerosis. Ann Clin Transl Neurol. 2021 Mar;8(3):631-638.

Galetta KM, Bhattacharyya S. Multiple Sclerosis and Autoimmune Neurology of the Central Nervous System. Med Clin North Am. 2019 Mar;103(2):325-336.

Dugue R, Kim C, Boruah A, Harrigan E, Sun Y, Thakur KT. Time to Confirmed Neuroinfectious Diagnoses: Diagnostic Testing and Resource Allocation. Neurohospitalist. 2024 Jul;14(3):296-300. doi: 10.1177/19418744241242957. Epub 2024 Mar 28. PMID: 38895000

Kvam, K. A., Stahl, J. P., Chow, F. C., Soldatos, A., Tattevin, P., Sejvar, J., Mailles, A. Outcome and Sequelae of Infectious Encephalitis. Journal of clinical neurology (Seoul, Korea) 2024; 20 (1): 23-36

Kvam KA, Stahl JP, Chow FC, Soldatos A, Tattevin P, Sejvar J, Mailles A. Outcome and Sequelae of Autoimmune Encephalitis. J Clin Neurol. 2024 Jan;20(1):3-22.   

Boruah AP, Kroopnick A, Thakkar R, Wapniarski AE, Kim C, Dugue R, Harrigan E, Lipkin WI, Mishra N, Thakur KT. Application of VirCapSeq-VERT and BacCapSeq in the diagnosis of presumed and definitive neuroinfectious diseases. J Neurovirol. 2023 Oct 18. Ann Clin Transl Neurol. 2022 Aug;9(8):1125-1135.

Hoang HE, Robinson-Papp J, Mu L, Thakur KT, Gofshteyn JS, Kim C, Ssonko V, Dugue R, Harrigan E, Glassberg B, Harmon M, Navis A, Hwang MJ, Gao K, Yan H, Jette N, Yeshokumar AK. Determining an infectious or autoimmune etiology in encephalitis. Ann Clin Transl Neurol. 2022 Aug;9(8):1125-1135. doi: 10.1002/acn3.51608. Epub 2022 Jun 17.

Galetta K, Gheihman G, Rosen A, Klein JP, Bhattacharyya S. Influence of Autoimmune Antibody Testing on the Use of Immunotherapy on an Inpatient Neurology Service. Neurohospitalist. 2021 Jul;11(3):214-220.

Broadhurst MJ, Dujari S, Budvytiene I, Pinsky BA, Gold CA, Banaei N. Utilization, Yield, and Accuracy of the FilmArray Meningitis/Encephalitis Panel with Diagnostic Stewardship and Testing Algorithm. J Clin Microbiol. 2020 Aug 24;58(9)

Gu, W., Rauschecker, A. M., Hsu, E., Zorn, K. C., Sucu, Y., Federman, S., Gopez, A., Arevalo, S., Sample, H. A., Talevich, E., Nguyen, E. D., Gottschall, M., Nourbakhsh, B., Gold, C. A., Cree, B. A., Douglas, V. C., Richie, M. B., Shah, M. P., Josephson, S. A., Gelfand, J. M., Miller, S., Wang, L., Tihan, T., DeRisi, J. L., Chiu, C. Y., Wilson, M. R. Detection of Neoplasms by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid.  JAMA neurology 2021 Nov 1;78(11):1355-66.

Slawski D, Lyman KA, Thatikunta P, Gold CA, Albers GW. Cerebral Perfusion Imaging and Plateau Waves. Stroke. 2023 May;54(5):e224-e228.

Carberry N, Yu S, Fayerman RN, Dugue R, Miller M, Tanji K, Goyal T, Canoll P, Brannagan TH 3rd. Leptomeningeal Disease Secondary to Thr60Ala Transthyretin Amyloidosis: Case Report and Review of the Literature. Neurohospitalist. 2023 Jan;13(1):90-95.

Dugue R, Schnall R, Liu M, Brickman AM, Pavol M, Porra T, Gutierrez J. Uncontrolled HIV and inflammation is associated with intracranial saccular aneurysm presence. AIDS. 2022 Jun 1;36(7):991-996.

Galetta K, Bhattacharyya S. Acute Neurologic Manifestations of Systemic Immune-Mediated Diseases. Semin Neurol. 2021 Oct;41(5):541-553.

Threlkeld ZD, Scott BJ. Neuro-Oncologic Emergencies. Neurol Clin. 2021 May;39(2):545-563.

Miller EH, Namale VS, Kim C, Dugue R, Waldrop G, Ciryam P, Chong AM, Zucker J, Miller EC, Bain JM, Willey JZ, Doyle K, Boehme A, Claassen J, Uhlemann AC, Thakur KT. Cerebrospinal Analysis in Patients With COVID-19. Open Forum Infect Dis. 2020 Oct 18;7(11)

Nie EH, Su YJ, Baird JH, Agarwal N, Bharadwaj S, Weng WK, Smith M, Dahiya S, Han MH, Dunn JE, Kipp LB, Miklos DB, Scott BJ, Frank MJ. Clinical features of neurotoxicity after CD19 CAR T-cell therapy in mantle cell lymphoma. Blood Adv. 2024 Mar 26;8(6):1474-1486.  

Nie EH, Su YJ, Baird JH, Agarwal N, Bharadwaj S, Weng WK, Smith M, Dahiya S, Han MH, Dunn JE, Kipp LB, Miklos DB, Scott BJ, Frank MJ. Clinical Features of Neurotoxicity Following CD19 CAR T-cell Therapy in Mantle Cell Lymphoma. Blood Adv. 2024 Jan 31: bloodadvances.2023011896. doi: 10.1182/bloodadvances.2023011896. Online ahead of print.PMID: 38295285

Song KW, Scott BJ, Lee EQ. Neurotoxicity of Cancer Immunotherapies Including CAR T Cell Therapy. Curr Neurol Neurosci Rep. 2023 Dec;23(12):827-839.

Mahdi J, Dietrich J, Straathof K, Roddie C, Scott BJ, Davidson TB, Prolo LM, Batchelor TT, Campen CJ, Davis KL, Gust J, Lim M, Majzner RG, Park JR, Partap S, Ramakrishna S, Richards R, Schultz L, Vitanza NA, Wang LD, Mackall CL, Monje M. Tumor inflammation-associated neurotoxicity. Nat Med. 2023 Apr;29(4):803-810.

Nie EH, Ahmadian SS, Bharadwaj SN, Acosta-Alvarez L, Threlkeld ZD, Frank MJ, Miklos DB, Monje M, Scott BJ, Vogel H. Multifocal demyelinating leukoencephalopathy and oligodendroglial lineage cell loss with immune effector cell-associated neurotoxicity syndrome (ICANS) following CD19 CAR T-cell therapy for mantle cell lymphoma. J Neuropathol Exp Neurol. 2023 Jan 20;82(2):160-168.

Satyanarayan S, Spiegel J, Hovsepian D, Markert M, Thomas R, Muffly L, Miklos D, Graber K, Scott BJ. Continuous EEG monitoring detects nonconvulsive seizure and Ictal-Interictal Continuum abnormalities in moderate to severe ICANS following systemic CAR-T therapy. Neurohospitalist. 2023 Jan;13(1):53-60.

Reveron-Thornton R, Scott BJ, Post D, Caulfield AF, Werbaneth K, Hovsepian DA, Spiegel J, Miklos D, Thomas RP, Patel CB. Recurrent Status Epilepticus in the Setting of Chimeric Antigen Receptor (CAR)-T Cell Therapy. Neurohospitalist. 2022 Jan;12(1):74-79.