Stanford Movement Disorders Center Clinical Trials

PARKINSON’S DISEASE

The natural history of synucleinopathies
PI: Mitchell Miglis, MD
Study status: Open by invitation only
Research coordinator:  Sia Boumis
siaboumis@stanford.edu, 650-245-7454.

Sodium Oxybate in Refractory REM Sleep Behavior Disorder: A Randomized Controlled Study
Purpose: This study evaluates the efficacy of sodium oxybate in individuals with and without Parkinson’s disease who act out their dreams (REM Sleep Behavior Disorder, known as “RBD”) and do not respond to usual therapies.
PI: Emmanuel H. Druing, MD
Co-PI: Mitchell Miglis, MD
Study status: Open, enrollment ongoing
Research coordinator: Polina Davidenko
pdaviden@stanford.edu (650) 721-7552

Neurodegeneration and Brain Function in Aging with HIV and Parkinson's Disease
Sponsor: NIH/NINDS
Site PI: Helen Bronte-Stewart, M.D., M.S.
Study Status: Open, enrollment ongoing
Research coordinator: Varsha Prabhakar
varshap@stanford.edu (650-723-6709)

Frequency Effects of Deep Brain Stimulation on Movement in Parkinson’s Disease.
PI: Helen Bronte Stewart, M.D., M.S.
Study status: Open, enrollment by invitation only
Research coordinator: Chioma Anidi
canidi@stanford.edu (650-723-6709)

The Stanford Parkinson's Disease Plasma Study
Clinical Trials Protocol #: NCT02968433
PI: Helen Bronte-Stewart, M.D., M.S.
Study Status: Open, enrollment ongoing
Research coordinator: Amaris Martinez
amaris94@stanford.edu (650-723-6709)

Pacific Udall Center
Sponsor: NIH/NINDS Morris K. Udall Center of Excellence for Parkinson's Disease Research
PI: Tom Montine, MD, PhD
Study status: Open, Enrollment ongoing
Research coordinator: Christine Blabe, MS
udallcenter@stanford.edu
  (650) 721-5351

Healthy Brain Aging Study
Sponsor: NIH/NIA
PI: Victor Henderson, M.D. and Tony Wyss-Coray, Ph.D
Study Status: Open, enrollment ongoing
Research coordinator: Christina Wyss-Coray
ADRCstanford@stanford.edu (650) 721-2409

Development of Multimodal Imaging Biomarkers for Cognitive Dysfunction in Parkinson's Disease
Sponsor: The Michael J. Fox Foundation for Parkinson’s disease Research
PI: Kathleen Poston, M.D., M.S.
Study status: Enrollment closed, study ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060  

Structural Correlates of Cognitive and Motor Dysfunction in Parkinsonian Disorders
PI: Kathleen Poston, M.D., M.S.
Study Status: Enrollment closed, study ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060  

Functional Networks in Parkinson's Disease - an fMRI Activation and Functional Connectivity Study
Sponsor: NIH/NINDS
PI: Kathleen Poston, M.D., M.S.
Study Status: Closed to enrollment, analysis ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060  

A Phase 1/2 Trial Assessing the Safety and Efficacy of Bilateral Intraputaminal and Intranigral Administration of CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN]) in Subjects With Idiopathic Parkinson’s Disease
Clinical Trials Protocol #: NCT00400634
Sponsor: Sangamo Biosciences, Inc
Site PI: Kathleen Poston, M.D., M.S.
Study Status: Closed to enrollment, outcome published
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060  

Neural Signatures of Tremor, Bradykinesia and Freezing in the Subthalamic Region in Parkinson’s Disease and their Acute and Long-Term Modulation by Subthalamic Deep Brain Stimulation
Clinical Trials Protocol #: NCT01990313
Sponsor: Medtronic
PI: Helen Bronte Stewart, M.D., M.S.
Study status: Open, enrollment by invitation only
Research coordinator: Chioma Anidi
canidi@stanford.edu (650-723-6709)

Adaptive Closed Loop Neuromodulation and Neural Signatures of Parkinson's Disease (aDBS)
Clinical Trials Protocol #: NCT02384421
Sponsor: Medtronic, Michael  J. Fox Foundation
PI: Helen Bronte Stewart, M.D., M.S.
Study status: Open, enrollment by invitation only
Research coordinator: Chioma Anidi
canidi@stanford.edu (650-723-6709)

Frequency Effects of Deep Brain Stimulation on Movement in Parkinson’s Disease.
PI: Helen Bronte Stewart, M.D., M.S.
Study status: Open, enrollment by invitation only
Research coordinator: Chioma Anidi
canidi@stanford.edu (650-723-6709)

Effect of LY3154207 on Cognition in Mild-to-Moderate Parkinson’s Disease Dementia (NCT03305809)
Study Status: Active, Enrolling
PI: Melanie Lising, MD
Research Coordinator: Chris Jo
Contact: chris24j@stanford.edu

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study, with an Active-Treatment Dose-Blinded Period, to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Subjects with Parkinson’s Disease (NCT03318523)
Study Status: Active, Enrolling
PI: Laurice Yang, MD
Research Coordinator: Chris Jo
Contact: chris24j@stanford.edu

Multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of GZ/SAR402671 in patients with early-stage Parkinson’s disease carrying a GBA mutation or other pre-specified variant (NCT02906020)
Study Status: Active, Enrolling
PI: Kathleen Poston, M.D., M.S.
Research Coordinator: Emma Adair
Contact: eadair@stanford.edu

ATYPICAL PARKINSONISM (MSA, PSP, CBD, DLB)

The Natural History of Synucleinopathies
PI: Mitchell Miglis, MD
Study status: Open by invitation only
Research coordinator:  Sia Boumis
siaboumis@stanford.edu  650-245-7454

ESSENTIAL TREMOR

Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors
Clinical Trials Protocol#: NCT02289560
Sponsor: Insightec
Site PI: Pejman Ghanouni, MD, PhD
Study status: Enrollment Closed, analysis ongoing
Research coordinator: Kathy McDonald
kmcdonal@stanford.edu

Research Programs