Stanford Movement Disorders Center Clinical Trials

PARKINSON'S DISEASE

Sodium Oxybate in Refractory REM Sleep Behavior Disorder: A Randomized Controlled Study
Purpose: This study evaluates the efficacy of sodium oxybate in individuals with and without Parkinson’s disease who act out their dreams (REM Sleep Behavior Disorder, known as “RBD”) and do not respond to usual therapies.
PI: Emmanuel H. During, MD
Co-PI: Mitchell Miglis, MD
Study status: Open, enrollment ongoing
Research coordinator: Adrian Ekelmans
adrian01@stanford.edu (916) 606-6215

Pacific Udall Center
Sponsor: NIH/NINDS Morris K. Udall Center of Excellence for Parkinson's Disease Research
PI: Tom Montine, MD, PhD
Study status: Open, Enrollment ongoing
Research coordinator: Maria-Lucia Campos
udallcenter@stanford.edu
  (650) 721-5274

Healthy Brain Aging Study
Sponsor: NIH/NIA
PI:Victor Henderson, M.D. and Tony Wyss-Coray, Ph.D
Study Status: Open, enrollment ongoing
Research coordinator: Christina Wyss-Coray
ADRCstanford@stanford.edu (650) 721-2409

Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic Feedback (NCT04043403)
Sponsor(s): NIH/NINDS, BRAIN Initiative
Purpose: This study aims to investigate the safety and feasibility of adaptive deep brain stimulation for impaired gait and freezing of gait in Parkinson’s disease, driven by subject-specific neural or behavioral control variables, and in response to medication.
PI: Helen Bronte-Stewart, M.D.,M.S.E.
Study status: Open, enrollment ongoing
Research coordinator: Yasmine Kehnemouyi
ykehn97@stanford.edu (650) 723-6709

Neural Signatures of Tremor, Bradykinesia and Freezing in the Subthalamic Region in Parkinson’s Disease and their Acute and Long-Term Modulation by Subthalamic Deep Brain Stimulation
Clinical Trials Protocol #: NCT01990313
Sponsor: Medtronic
PI: Helen Bronte Stewart, M.D., M.S.
Study status: Closed to enrollment, study ongoing
Research coordinator: Chioma Anidi
canidi@stanford.edu (650-723-6709)

The natural history of synucleinopathies
PI: Mitchell Miglis, MD
Study status: Open, enrollment by invitation only
Research coordinator: Jordan Seliger
jseliger@gmail.com

Structural Correlates of Cognitive and Motor Dysfunction in Parkinsonian Disorders
PI: Kathleen Poston, M.D., M.S.
Study Status: Closed to enrollment, study ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060  

Functional Networks in Parkinson's Disease - an fMRI Activation and Functional Connectivity Study
Sponsor: NIH/NINDS
PI:Kathleen Poston, M.D., M.S.
Study Status: Closed to enrollment, analysis ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060  

 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study, with an Active-Treatment Dose-Blinded Period, to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Subjects with Parkinson’s Disease (NCT03318523)
Study Status: Closed to enrollment, analysis ongoing
PI: Laurice Yang, MD, MHA

Multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of GZ/SAR402671 in patients with early-stage Parkinson’s disease carrying a GBA mutation or other pre-specified variant (NCT02906020)
Study Status: Closed to enrollment, analysis ongoing
PI: Kathleen Poston, M.D., M.S.
Research Coordinator: Emma Adair
Contacteadair@stanford.edu

Neurodegeneration and Brain Function in Aging with HIV and Parkinson's Disease
Sponsor: NIH/NINDS
Site PI: Helen Bronte-Stewart, M.D., M.S.
Study Status: Closed to enrollment, analysis ongoing
Research coordinator: (650-723-6709)

Development of Multimodal Imaging Biomarkers for Cognitive Dysfunction in Parkinson's Disease
Sponsor: The Michael J. Fox Foundation for Parkinson’s disease Research
PI: Kathleen Poston, M.D., M.S.
Study status: Enrollment closed, study ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060  

The Stanford Parkinson's Disease Plasma Study
Clinical Trials Protocol #: NCT02968433
PI: Helen Bronte-Stewart, M.D., M.S.
Study Status: Closed to enrollment, analysis ongoing
Research coordinator: (650-723-6709)

A Phase 1/2 Trial Assessing the Safety and Efficacy of Bilateral Intraputaminal and Intranigral Administration of CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN]) in Subjects With Idiopathic Parkinson’s Disease
Clinical Trials Protocol #: NCT00400634
Sponsor: Sangamo Biosciences, Inc
Site PI: Kathleen Poston, M.D., M.S.
Study Status: Closed to enrollment, outcome published
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060

Effect of LY3154207 on Cognition in Mild-to-Moderate Parkinson’s Disease Dementia (NCT03305809)
Study Status: Closed to enrollment, study ongoing
PI: Laurice Yang, MD, MHA
Research CoordinatorStephanie Tran
Contact: trans@stanford.edu

ATYPICAL PARKINSONISM (MSA, PSP, CBD, DLB)

The Natural History of Synucleinopathies
PI: Mitchell Miglis, MD
Study status: Open by invitation only
Research coordinator:  Sia Boumis
siaboumis@stanford.edu  650-245-7454

M-STAR
Sponsor: Biohaven
Site PI: Mitchell Miglis, MD
Study status: Open, enrollment ongoing
Research coordinator:  Ruba Shaik
rubas@stanford.edu 650-546-1436

ESSENTIAL TREMOR

Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors
Clinical Trials Protocol#: NCT02289560
Sponsor: Insightec
Site PI: Pejman Ghanouni, MD, PhD
Study status: Enrollment Closed, analysis ongoing
Research coordinator: Kathy McDonald
kmcdonal@stanford.edu

HUNTINGTON’S DISEASE

Generation HD
Clinical Trials Protocol#: NCT03761849
Sponsor: Roche
Site PI: Brent Bluett, D.O.
Study status: Enrollment Closed, trial ongoing
Research coordinator: Christine Lin
clin@stanford.edu

UPCOMING CLINICAL TRIALS

PARKINSON’S DISEASE

Study Comparing Continuous Subcutaneous Infusion Of ABBV-951 With Oral Carbidopa/Levodopa Tablets For Treatment Of Motor Fluctuations In Adult Participants With Advanced Parkinson's Disease
Clinical Trials Protocol#: NCT04380142
Sponsor: Abbvie
Site PI: Brent Bluett, D.O.
Study status: Pending, open to enrollment in September 2020
Research coordinator: Lila Perrone
perronel@stanford.edu

ADX48621 for the Treatment of Levodopa Induced Dyskinesia in Patients With Parkinson's Disease
Clinical Trials Protocol#: NCT01336088
Sponsor: Addex Pharmaceuticals
Site PI: Brent Bluett, D.O.
Study status: Pending, open to enrollment in September 2020
Research coordinator: Lila Perrone
perronel@stanford.edu

Open-Label Study With Pimavanserin on Activities of Daily Living in Subjects With Parkinson's Disease Psychosis
Clinical Trials Protocol#: NCT04292223
Sponsor: Acadia
Site PI: Brent Bluett, D.O.
Study status: Pending, open to enrollment in September 2020
Research coordinator: Lila Perrone
perronel@stanford.edu

ATYPICAL PARKINSONISM

UCB-PSP001 - PHASE 3 STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF UCB0107 IN SUBJECTS WITH PROGRESSIVE SUPRANUCLEAR PALSY (PSP)
Sponsor: UCB
Site PI: Brent Bluett, D.O.
Study status: Delayed due to COVID-19, will begin enrolling in April 2021
Research coordinator: Lila Perrone
perronel@stanford.edu