Pediatric Neuro-Oncology Clinical Trials

New Diagnoses

ACNS0332

Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

ACNS0831

Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years

SJMB12

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

SJATRT

Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT

Recurrent/Refractory Diseases

SJATRT

 Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT

Everolimus

Phase II Study of Everolimus (RAD001, Afintor) For Children with Recurrent or Progressive Ependymoma

POETIC G029665

A Phase I/II, Multicenter, Open-Label Dose-Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously Treated Solid Tumors

ABBVIE - M14-483

ABT-414 alone or ABT-414 plus temozolomide versus lomustine or temozolomide for recurrent glioblastoma: a randomized phase II study of the EORTC Brain Tumor Group

LOXO-TRK-15003

A Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101in Pediatric Patients with Advanced Solid or Primary Central Nervous System Tumors

ADVL1622

Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

Ancillary Studies

ALTE07C1

Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer

PBTC-N12

A Phase II Study of (18F) FLT for PET imaging of brain tumors in children

NF1-OPG Natural History Study

Developing Evidence-Based Criteria for Initiating Treatment for Neurofibromatosis Type 1 Associated Optic Pathway Glioma/CTF 004: The Collection of Blood Samples from Patients With NF1 for Research Purposes

For more information

To find out the current status of any study please contact us at: Neuroonc@stanfordchildrens.org