Pediatric Neuro-Oncology Clinical Trials

New Diagnoses

ACNS0332

Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

ACNS0831

Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years

SJMB12

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

SJATRT

Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT

ACNS1123

Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)

ACNS1422

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients

Recurrent/Refractory Diseases

SJATRT

 Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT

POETIC G029665

A Phase I/II, Multicenter, Open-Label Dose-Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously Treated Solid Tumors

ABBVIE - M14-483

ABT-414 alone or ABT-414 plus temozolomide versus lomustine or temozolomide for recurrent glioblastoma: a randomized phase II study of the EORTC Brain Tumor Group

LOXO-TRK-15003

A Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101in Pediatric Patients with Advanced Solid or Primary Central Nervous System Tumors

ADVL1622

Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

Celgene (CC-4047)

A Phase 2 Clinical Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults with Recurrent or Progressive Primary Brain Tumors

Ancillary Studies

ALTE07C1

Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer

PBTC-N12

A Phase II Study of (18F) FLT for PET imaging of brain tumors in children

NF1-OPG Natural History Study

Developing Evidence-Based Criteria for Initiating Treatment for Neurofibromatosis Type 1 Associated Optic Pathway Glioma/CTF 004: The Collection of Blood Samples from Patients With NF1 for Research Purposes

For more information

To find out the current status of any study please contact us at: Neuroonc@stanfordchildrens.org