Clinical Research & Test Development

At Stanford Medicine's Department of Pathology, clinical research and test development stand at the forefront of advancing diagnostic and therapeutic methodologies. With an unwavering commitment to innovation and excellence, the Department plays a pivotal role in translating cutting-edge scientific discoveries into tangible clinical applications. Through collaborative efforts across multidisciplinary teams, researchers and clinicians harness the power of advanced molecular biology tools, innovative biomarker identification methods, and state-of-the-art imaging techniques to offer insights into disease mechanisms that pave the way for personalized and targeted therapeutic interventions. 

The Test Development Program launched in 2023 leverages these technologies and collaborative efforts to develop diagnostic tests that not only provide accurate, precise, and timely results but also drives the translation of scientific discoveries into tangible benefits for patients.  The Program aims to foster earlier and more accurate diagnoses, expand precision medicine tools, reduce diagnostic uncertainty, enhance the monitoring of treatment response, and improve cost-effectiveness through the development of increasingly effective and innovative diagnostic tests. 

Within this dynamic environment, the focus extends beyond just enhancing diagnostic accuracy to pushing the boundaries of what’s possible to personalize medicine, discover prognostic markers, and develop targeted therapies tailored to individual patient profiles. By leveraging emerging technologies and extensive clinical datasets, Stanford Medicine's Department of Pathology not only pioneers novel diagnostic methods but also validates their efficacy through rigorous clinical trials. This dedication to evidence-based practice ensures that breakthroughs in research seamlessly integrate into the standard of care, ultimately improving patient outcomes and reshaping the landscape of modern medicine.

Featured Publications on Clinical Research in Pathology

Blood, 2023
Amna Malik, Anwar A Sayed, Panpan Han, Michelle M H Tan, Eleanor Watt, Adela Constantinescu-Bercu, Alexander T H Cocker, Ahmad Khoder, Rocel C Saputil, Emma Thorley, Ariam Teklemichael, Yunchuan Ding, Alice C J Hart, Haiyu Zhang, Wayne A Mitchell, Nesrina Imami, James T B Crawley, Isabelle I Salles-Crawley, James B Bussel, James L Zehnder, Stuart Adams, Bing M Zhang, Nichola Cooper

"The role of CD8+ T-cell clones in immune thrombocytopenia"

Stanford Pathology Contributors

James L. Zehnder, MD

Director of Clinical Pathology
Director, Coagulation Laboratory

Bing Melody Zhang, MD

Co-Director of Histocompatibility and Immunogenetics Laboratory, Associate Section Director of Molecular Pathology Laboratory

Journal of Clinical Microbiology, 2023
Philip L. Bulterys, Nicole Y. Leung, Atif Saleem, Indre Budvytiene, Benjamin A. Pinsky, Niaz Banaei

Postpandemic Effects of COVID-19 Shelter-in-Place Orders on the Gastrointestinal Pathogen Landscape

In 2020, California enforced several unprecedented stay-at-home orders to curb the spread of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). First, a strict shelter-in-place (SIP) order was issued in March 2020, followed by a gradual reopening of restaurants in May 2020 and then schools in September 2020. A winter surge of coronavirus disease 2019 (COVID-19) cases forced a conditional stay-at-home order in December 2020, which was lifted in January 2021, a month before mass COVID-19 vaccination sites opened...

Stanford Pathology Contributors

Philip Bulterys, MD, PhD

Hematopathology Fellow
Stanford Pathology

Atif Saleem, DO

Dermatopathology Fellow
Stanford Pathology

Niaz Banaei, MD

Professor of Pathology and Medicine (Infectious Diseases)

Benjamin Pinsky, MD, PhD

Professor of Pathology and Medicine (Infectious Diseases)