Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support

The Heart Failure, Cardiac Transplant and Mechanical Circulatory Support affinity group at Stanford consists of a group of physicians who specialize in a variety of subspecialties of heart failure management and work in an integrated manner with nurses, dietitians, pharmacists, and social workers to provide highly specialized and comprehensive care to patients with heart failure, and offer cardiac transplantation and mechanical circulatory support for those with end-stage disease.

Heart Failure Clinics

The Stanford Center for Inherited Cardiovascular Disease is led by Dr. Euan Ashley and encompasses a diverse group of physicians and genetic counselors who treat patients with genetic myopathies such as hypertrophic cardiomyopathy, arrhythmogenic right ventricular dysplasia, channelopathies and Marfan syndrome.  The group has now become the largest hypertrophic cardiomyopathy center west of the Rockies.

The Stanford Amyloid Center is headed by Dr. Ronald Witteles who works in close collaboration with his colleagues in hematology to provide comprehensive evaluation and care for patients with amyloid heart disease. Dr. Witteles also specializes in the treatment of patients with cardiac sarcoidosis and chemotherapy-related cardiomyopathy.

The Stanford Heart Failure clinic provides care to patients with advanced heart failure and evaluates patients for cardiac transplantation and mechanical circulatory support.  The multidisciplinary clinic provides longitudinal care and collaborates with colleagues in electrophysiology, the structural heart program, cardiac surgery and the adult congenital heart disease program.

Stanford is also has a Center for Undiagnosed Diseases that is part of the multi-institutional Undiagnosed Disease Network funded through the National Institutes of Health.  It is a multi-disciplinary research center focused on diagnosing rare and unknown diseases utilizing whole genome sequencing.

Cardiac Transplantation

The field of heart transplantation started in the 1960s at Stanford with initial experiments by Norman Shumway and culminated in the first heart transplant in the United States in 1968.  In 2018 the program will celebrate the 50th anniversary of this landmark event.  In addition to being the first heart transplant center in the United States, it has also made several landmark contributions to the field, including development of the endomyocardial biopsy, the development of a biopsy grading scheme, the introduction of cold preservation, the first heart-lung transplant and the development of intravascular ultrasound to assess for cardiac allograft vasculopathy.

Other major advances in the field of heart transplantation pioneered by clinicians and investigators at Stanford include the recognition of the role of cytomegalovirus  infection in the development of chronic rejection, the use of peripheral gene expression testing for non-invasive rejection surveillance, and most recently, the development of a novel cell-free DNA assay for early detection of graft injury.

Stanford remains a leader in the field of heart failure and heart transplantation, and is proud that its trainees hold distinguished leadership positions at transplant centers around the world.

Mechanical Circulatory Support

Stanford has a long history of involvement in the field of mechanical circulatory support, dating to 1984 with the implantation of the Novacor LVAD as a bridge to transplantation.  The mechanical circulatory support program has continued to grow under the leadership of the medical director, Dr. Dipanjan Banerjee and in conjunction with the surgical leadership of Drs. Joseph Woo and Will Hiesinger.  The program implants 40-50 VADs a year as both bridge to transplantation and destination therapy.  The majority of the implants are with the HVAD (Medtronic, US) and HeartMate3 (Abbott, US).

Advanced Heart Failure Transplant Cardiology (AHFTC) Fellowship Program

The Heart Failure Transplant fellowship program was established in 1989, received ACGME accreditation in 2013 and currently accepts three fellows per year.

Faculty

Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Bio

Dr. Teuteberg is board certified in Cardiology and Heart Failure and Transplantation. He is currently the Section Chief of Heart Failure, Cardiac Transplantation, and Mechanical Circulatory Support. He sees patients both in the clinic and in the hospital with advanced heart failure and who have received cardiac transplantation or mechanical circulatory support. His research interests are in clinical outcomes in patients after transplant and mechanical support as well as novel approaches to immunosuppression. He has participated in many single-center and multi-institutional research studies and has published widely in the fields of transplant and mechanical support. He will serve as President of the International Society of Heart and Lung Transplantation in 2018.
Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Bio

After growing up in the Philippines (albeit of Indian descent), Kiran Kaur Khush graduated with Honors and Distinction in Biological Sciences from Stanford University. She completed her medical training at Harvard University and medical residency at the University of California at San Francisco (UCSF), followed by general cardiology training and advanced training in heart failure, heart transplantation, pulmonary hypertension, and echocardiography at UCSF. She then joined the faculty at UCSF while concomitantly earning a Masters’ Degree in Clinical Research and Epidemiology. Dr. Khush moved back to Stanford University in 2008 upon joining the faculty in the Division of Cardiovascular Medicine, where she focuses on clinical and translational research in the field of heart transplantation. She also maintains an active general cardiology practice. Mother to three young children, Dr. Khush enjoys international travel and a quiet moment with a good book.
Associate Dean, School of Medicine, Professor of Medicine (Cardiovascular), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology at the Stanford University Medical Center

Bio

Born in Scotland, Dr. Ashley graduated with 1st class Honors in Physiology and Medicine from the University of Glasgow. He completed medical residency and a PhD in molecular physiology at the University of Oxford before moving to Stanford University where he trained in cardiology and advanced heart failure, joining the faculty in 2006. His group is focused on the science of precision medicine. In 2010, he led the team that carried out the first clinical interpretation of a human genome. The article became one of the most cited in clinical medicine that year and was later featured in the Genome Exhibition at the Smithsonian in DC. Over the following 3 years, the team extended the approach to the first whole genome molecular autopsy, to a family of four, and to a case series of patients in primary care. They now routinely apply genome sequencing to the diagnosis of patients at Stanford hospital where Dr Ashley directs the Clinical Genome Program and the Center for Inherited Cardiovascular Disease. Dr Ashley was the first co-chair of the steering committee of the NIH Undiagnosed Diseases Network. He was a recipient of the National Innovation Award from the American Heart Association and the NIH Director’s New Innovator Award. He is part of the winning team of the $75m One Brave Idea competition and co-founder of three companies: Personalis Inc ($PSNL), Deepcell Inc, and SVExa Inc. He was recognized by the Obama White House for his contributions to Personalized Medicine and in 2018 was awarded the American Heart Association Medal of Honor for Genomic and Precision Medicine. He was appointed Associate Dean in 2019. Father to three young Americans, in his ‘spare’ time, he tries to understand American football, plays the saxophone, and conducts research on the health benefits of single malt Scotch whisky.
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Bio

Dr. Alexander is an advanced heart failure and transplant cardiologist at Stanford. He is also a member of the Stanford Amyloid Center and Stanford Cardiovascular Institute. He completed his internal medicine residency training at Johns Hopkins Hospital and cardiology fellowship at Brigham and Women’s Hospital/Harvard Medical School. He then finished his training in advanced heart failure and transplant cardiology at Stanford Hospital. He cares for patients in the clinic and in the hospital with advanced heart failure or those who underwent heart transplantation or mechanical circulatory support. His primary clinical and research interests lie in cardiac amyloidosis, in particular unraveling the molecular determinants of transthyretin amyloid cardiomyopathy to improve the diagnosis and treatment of this disease.
Professor of Medicine (Cardiovascular) at the Stanford University Medical Center

Bio

Dr. Michael Fowler is a Professor of Cardiovascular Medicine at Stanford Hospital & Clinics. Dr. Fowler attended the Charing Cross Hospital Medical School, London, England. He has been elected to be a fellow in the Royal College of Physicians. He came to Stanford University on a British Heart Foundation, American Heart Association reciprocal fellowship award. Dr. Fowler was appointed to the faculty in 1982. He is the Medical Director of the Heart Failure Program at Stanford University School of Medicine and Medical Director of the Stanford Cardiomyopathy Center. Dr. Fowler has specialized in the treatment and research related to heart failure for over 30 years. He played an important role in the development of beta blocking drugs to treat heart failure and has also participated in most and the major studies that have led to our current comprehensive treatment for heart failure with drugs and devices. He is an expert in evaluating patients who may benefit from cardiac transplantation or mechanical support therapy.
Clinical Professor, Medicine - Cardiovascular Medicine

Bio

Dr. Francois Haddad, MD is a Clinical Professor of Medicine that specializes in the field of cardio-vascular imaging, pulmonary hypertension, advanced heart failure and transplantation. Dr. Haddad has over 18 years of practice in the field of cardiology. He directs Stanford Cardiovascular Institute Biomarker and Phenotypic Core Laboratory dedicated to translational studies in cardiovascular medicine. The laboratory focuses on (1) identifying early biomarkers of heart failure and aging, (2) bioengineering approaches to cardiovascular disease modeling and (3) novel informatic approach for the detection and risk stratification of disease. He is involved is several precision medicine initiatives in health including the Project Baseline, the Integrated Personalized Omics Profiling Initiative, the Athletic screening program at Stanford and the Strong-D cardiac rehabilitation initiative in individuals with diabetes mellitus.
Instructor, Medicine - Cardiovascular Medicine

Bio

Dr. Kawana joined Advanced Heart Failure and Transplant Cardiology group in 2018 as an Instructor in the Division of Cardiovascular Medicine. He completed his internal medicine, cardiovascular medicine and heart failure training at Stanford. He also completed postdoctoral research fellowship under Dr. James Spudich in Department of Biochemistry. He sees advanced heart failure patients in clinic, and attends on inpatient service taking care of post-heart transplant patients and patients on MCS support. His research interests are in the fundamental mechanism of inherited cardiomyopathies, and he studies the effect of gene mutation on the cardiac sarcomere function using cutting-edge biochemical and biophysical approach, which would lead to development of novel pharmacotherapy that directly modulates cardiac muscle protein.
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center, Emerita
Clinical Assistant Professor, Medicine - Cardiovascular Medicine

Bio

I am a cardiologist and researcher with specialty interests in sports medicine, heart failure and exercise testing. My background includes clinical training in internal medicine and cardiology through the Royal Australasian College of Physicians. I have completed an advance cardiac imaging fellowship (Monash Heart) and a post doctoral fellowship in exercise physiology (Stanford University). I have a clinical interest cardiovascular health in those wanting to be active or who regularly exercise (athletes and non-athletes). My current research projects are aimed at defining inflammasome/metabolic pathways with exercise and optimizing the use of demographic data to predict exercise performance in healthy individuals and those with heart failure.
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Bio

Dr. Parikh is cardiologist specializing in the care of patients with inherited cardiovascular diseases. She completed clinical cardiology fellowship at Stanford School of Medicine and her medical residency at the University of California, San Francisco. Funded by research grant from the NIH, she currently studies multiple causes of cardiomyopathy in the laboratory. She has a particular clinical and scientific interest in inherited arrhythmogenic cardiomyopathies, which are an increasingly recognized disease entity. Dr. Parikh is currently using patient cohort genetics, high throughput molecular biology and human induced pluripotent stem cell derived cardiomyocytes to study variant pathogenicity in this disease.
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Bio

Karim Sallam, MD, is trained in Cardiovascular Medicine and Advanced Heart Failure.
Professor of Medicine (Cardiovascular) at the Stanford University Medical Center

Bio

Board certified in Internal Medicine, General Cardiology, Interventional Cardiology, and Heart Failure and Transplantation. Medical Director of Stanford Cardiac Care Unit since 1991. Clinical interests: CHF, advanced structural heart disease (heart muscle, coronary artery, valve, and pericardial), as well as post radiation and chemotherapy induced heart damage.
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Bio

I am a physician scientist with interests in cardiomyopathies, rare and undiagnosed diseases, therapeutics and genomics. I have research training in both myocardial and skeletal muscle biology and genetics, genomics, and multi-scale networks. In addition to my research training, I am a physician with interest and experience treating patients with hypertrophic cardiomyopathy and other inherited cardiomyopathies. I have clinical training in medicine, cardiology, cardiovascular genetics, and advanced heart failure. I have extensive translational science efforts, participating in several ongoing clinical trials for hypertrophic cardiomyopathy, dilated cardiomyopathy, ATTR cardiac amyloidosis, and mechanical circulatory support. I am Co-PI of Stanford’s NIH-funded Center for Undiagnosed Diseases a clinical site of the Undiagnosed Diseases Network. I am also a co-Investigator of the Bioinformatics Center of the Molecular Transducers of Physical Activity Consortium. I pursue projects and collaborations at the intersection of striated muscle genetics, genomics, and clinical investigation.
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Bio

Dr. Ronald Witteles is a Cardiologist who specializes in the treatment of patients with Heart Failure. He has particular expertise in the treatment of Amyloidosis, Sarcoidosis, and cardiac complications of cancer therapy (sometimes called "CardioOncology"). He serves as Co-Director of the Stanford Amyloid Center, one of the world's leading centers for the care of patients with amyloidosis, and serves as Co-Director of the Stanford Multidisciplinary Sarcoidosis Program. He is an Associate Editor for JACC: CardioOncology, the world's leading journal dedicated to the field of CardioOncology. Dr. Witteles has published extensively in his areas of expertise, and has won many awards for his excellence in both patient care and education. Dr. Witteles serves as Program Director for the Stanford Internal Medicine residency program -- directly supervising the training of more than 140 physicians each year. He holds board certification in Internal Medicine, Cardiovascular Disease, and Advanced Heart Failure/Transplant Cardiology.
Clinical Assistant Professor, Medicine - Cardiovascular Medicine

Administrative Staff

Dalia Gonzalez
Associate to Drs. Teuteberg, Khush, Hunt and Haddad

Cassandra Hawthorne 

Associate to  Drs. Schroeder, Fowler, Vagelos, Witteles, Jimenez and Sallam

Brooke Zelnik 
Associate to Drs. Ashley and Wheeler

Terra Coakley
Program Manager, Center for Inherited Cardiovascular Disease and Community Events Manager