NIH P01 Research Program Project Grant

-         Support for integrated, multi-project research projects involving a number of independent investigators who share knowledge and common resources

-         Each project contributes or is directly related to the common theme of the total research effort, thus forming a system of research activities and projects directed toward a well-defined research program goal

-         NHLBI P01

-         NIDDK P01

NIH P30 Center Core Grants

-         To support shared resources and facilities for categorical research by a number of investigators from different disciplines who provide a multidisciplinary approach to a joint research effort or from the same discipline who focus on a common research problem

-         The core grant is integrated with the center's component projects or program projects, though funded independently from them

NIH P50 Specialized Center

-         To support any part of the full range of research and development from very basic to clinical

-         May involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort

-         The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area

-         Receive continuous attention from staff funding IC

-         Centers may serve as regional or national resources for special research purposes

NIH Parent R01 with large budget approval

-         Request of $500,000 or more in direct costs in any one year

-         First-tier consortium and administrative (F&A) costs do not count against the direct cost limit

-         Parent R01 with large budget approval

NIGMS RM1

Collaborative Program Grant

-         Supports institutions/organizations that propose to conduct research to address complex and challenging biomedical problems, through deeply integrated, multidisciplinary research teams

-         Groups are typically c​​omprised of three to six principal investigators. The research topic must be central to the NIGMS mission areas ​and projects should not be achievable by individual efforts.

-         Applications must have well-defined goals that can be achieved within 5-10 years.

-         NIGMS RM1

NIH Director’s Transformative Research Awards

-         Supports individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies.

-         The Transformative Research application focuses on the importance of the problem, the novelty of the hypothesis and/or the proposed methodology, and the magnitude of the potential impact rather than on preliminary data or experimental details

-         NIH Director’s Transformative Research Awards

NIH Clinical Coordinating Center for Multi-Site Trials

-         Collaborative UG3/UH3 Clinical Trial Required

-         To develop and implement a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials.

-         Must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial

-         The objective of the CCC is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results.

-         CCC for Multi-Site Trials

NIH Data Coordinating Center for Multi-Site Trials

-         Supports Data Coordinating Center (DCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials

-          will utilize a milestone-driven cooperative agreement mechanism of award and runs in parallel with a CCC
The objective of the DCC application is to present a comprehensive plan to provide overall project coordination, administration, data management, and biostatistical support for the clinical trial proposed in the collaborating CCC application

-         DCC For Multi-Site Trials

AHA Strategically Focused Research Network

-         Focus on the understanding, prevention, diagnosis and treatment of a particular research topic of interest

-         Networks include 3-5 Centers working together. Each Center conducts synergistic research projects of scope equivalent to an R01, provides a training program for fellows, and is linked to the other Centers by AHA-organized interactions and meetings to accelerate exchange of ideas

-         AHA SFRN

Department of Defense (DoD) Focused Program Award

-         To improve the health, well-being, and care of all military Service Members, Veterans, and Beneficiaries, and its mission is to encourage, identify, select, and manage medical research projects of clear scientific merit that lead to impactful advances in military health care.

-         The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public

-         All applications must address one of the FY22 PRMRP Strategic Goals as it relates to the portfolio-assigned FY22 PRMRP Topic Area

-         Topic areas Related to CV Health:  Cardiomyopathy, Congenital Heart Disease, Familial Hypercholesterolemia, Hypercholesterolemia, Hypertension, Vascular Malformations, Women’s Heart Disease, Sustained Release Drug Therapy

-         DoD Focused Program Award

Patient-Centered Outcomes Research Institute (PCORI)

-         For high-quality comparative clinical effectiveness research (CER) projects that will address critical decisions faced by patients, caregivers, clinicians, and stakeholders across the health and healthcare community and for which there is insufficient evidence.

-         The proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions.

-         Proposed studies should compare interventions that already have established evidence of efficacy or are in widespread use.

-         Clinical interventions (such as medications, diagnostic tests, or procedures) and delivery system interventions are appropriate for these studies.

-         PCORI

LeDuc Foundation International Networks of Excellence 

-         An international grant-making organization which provides administrative services to the grant-making entities

-         Promotes internationally collaborative basic, translational, and clinical research in cardiovascular and neurovascular disease

-         The principal aim of this program is to foster outstanding and innovative scientific research by bringing together international teams of researchers with complementary expertise and resources to work together on a common thematic problem.

-         The proposals should aim to generate new knowledge with the potential to advance the diagnosis, prevention, and treatment of cardiovascular and/or neurovascular disease.

-         In the 2022-2023 application cycle, the Leducq Foundation will award four International Network of Excellence grants, each for an amount not to exceed U.S. $8,000,000 over five years.

-         LeDuc Foundation