MCHRI News & Updates
Monday, May 12, 2025, 12pm-1pm
Online via Zoom
Systemic Immune Dysregulation Induced by Hypertensive Disorders of Pregnancy Persists Years After Delivery
Hypertensive disorders of pregnancy (HDP), either preeclampsia of gestational hypertension, significantly increase the risk of cardiovascular disease (CVD) later in life. Using single-cell mass cytometry, the systemic immune system was analyzed across three time points: during pregnancy (antepartum), during the postpartum period (5-61 weeks post-pregnancy), and >2 years since last delivery (midlife). A multivariable sparse machine learning method with artificial noise injection and data-driven feature selection was utilized to identify HDP-associated immune signatures, highlighting that HDP-associated immune dysregulation persists long after pregnancy, potentially contributing to long-term maternal CVD risk.
Speakers:
Maximilian Sabayev, MS, ICME PhD candidate
Dorien Feyaerts, PhD, Instructor
Brice Gaudilliere, MD, PhD, Associate Professor of Anesthesiology, Perioperative and Pain Medicine and, by courtesy, of Pediatrics
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