Transdisciplinary Initiatives Program (TIP)

2022 Awards

Project Title: “High-dimensional Immunofluorescence Atlas of Tissue Architecture and Microbiome in Pediatric Fibro-stenosing Crohn's Disease
PI: Stephan Rogalla, MD, PhD. Medicine - Gastroenterology and Hepatology (School of Medicine)
Co-PI: Olav Solgaard, PhD. Director, Edward Ginzton Laboratory and Professor of Electrical Engineering (School of Engineering).

Project Title: Investigating the potential of quorum sensing molecules, produced by Pseudomonas aeruginosa, to produce sensory hearing loss in chronic suppurative otitis media
PI: Peter Santa Maria, MD, PhD. Otolaryngology - Head and Neck Surgery (School of Medicine)
Co-PI: Lynette Cegelski, PhD. Chemistry and, by courtesy, of Chemical Engineering (School of Humanities and Sciences)

Project Title: “Instant ELISA: Extremely Rapid Biomarker Detection at the Bedside”
PI: Tom Soh, MS, PhD. Radiology, Electrical Engineering, and By Courtesy Chemical Engineering and Bioengineering (School of Engineering)
Co-PI: Timothy Cornell, MD. Pediatric Critical Care Medicine (School of Medicine)

Project Title: “Novel biopsy-free preimplantation genetic testing in embryos”
PI: Bo Yu, MD, MS. Obstetrics & Gynecology - Reproductive Endocrinology & Infertility (School of Medicine)
Co-PI: Stanley Qi, PhD. Bioengineering (School of Engineering)

Project Title: “Going from Manually-crafted to Digitally-designed Oral Devices: A Digital Workflow to Treat Neonates with Cleft Lip and/or Palate or Robin Sequence to Ameliorate Surgical Procedures.”
PI: HyeRan Choo, DDS, DMD, MS. Plastic and Reconstructive Surgery (School of Medicine)
Co-PI: Joseph Desimone, PhD. Radiology, Chemical Engineering and, by courtesy, of Chemistry, of Materials Science and Engineering, and of Operations IT at GSB (School of Engineering)

2021 Awards

Project Title: In Vivo Evaluation of Short Bowel Function Using Soft Bioelectronic Sensors
PI: James Dunn, MD, PhD, School of Medicine (Surgery)
Co-PI: Zhenan Bao, PhD, School of Engineering (Chemical Engineering)

Project Title: AI to Monitor Maternal and Child Health Globally in Near Real Time and At an Extremely High Spatial Resolution: A Proof-Of-Concept Study
PI: Pascal Geldsetzer, MD, PhD, MPH, School of Medicine (Medicine)
Co-PIs: Marshall Burke, PhD, School of Earth, Energy & Environmental Sciences (Earth System Science); Gary Darmstadt, MD, MS, School of Medicine (Pediatrics); David Lobell, PhD, School of Earth, Energy & Environmental Sciences (Earth System Science); Stefano Ermon, PhD, School of Engineering (Computer Science)

Project Title: Data-Driven Approach to Personalized Type 1 Diabetes for Underserved Populations Facilitated by Continuous Glucose Monitor Data and Telehealth: Scaling Beyond Lucile Packard Children's Hospital
PI: Ramesh Johari, PhD, School of Engineering (Management Science & Engineering)
Co-PIs: David Maahs, MD, PhD, School of Medicine (Pediatrics); Priya Prahalad, MD, School of Medicine (Pediatrics); David Scheinker, PhD, School of Medicine (Pediatrics)

Project Title: FocusLab
PI: Anthony Norcia, PhD, School of Humanities and Sciences (Psychology)
Co-PIs: Tawna Roberts, OD, PhD, School of Medicine (Ophthalmology); Euna Koo, MD, School of Medicine (Ophthalmology); Scott R. Lambert, School of Medicine (Ophthalmology); Ann Shue, MD, School of Medicine (Ophthalmology)

Project Title: Examining Communication and Marketing Strategies to Reduce Food Insecurity among Latinx Children in California's San Joaquin Valley
PI: Anisha Patel, MD, MSPH, MSHS, School of Medicine (Pediatrics)
Co-PI: Szu-Chi Huang, MA, PhD, Graduate School of Business (Marketing)

Project Title: Using Maternal Metabolomic Profiles to Determine Gestational Age and Risk of Preterm Birth and Preeclampsia in Low Resource Settings
PI: Victoria Ward, MD, School of Medicine (Pediatrics)
Co-PIs: David K. Stevenson, MD, School of Medicine (Pediatrics); Andrea Montanari, PhD, School of Engineering (Electrical Engineering and Statistics); Mohsen Bayati, PhD, MSc, Graduate School of Business (Operations, Information & Technology); Gary L. Darmstadt, MD, MS, School of Medicine (Pediatrics); Karl G. Sylvester, MD, School of Medicine (Surgery)

2020 Awards

Project Title: Modeling the Earliest Developmental Stages of Human Cardiac Vascularization using Pluripotent Stem Cells
PI: Daniel Bernstein, MD, Professor, School of Medicine (Pediatrics)
Co-Is: Oscar J. Abilez, MD, PhD, Instructor, School of Medicine (Medicine); Ellen Kuhl, MS, PhD, Professor, School of Engineering (Mechanical Engineering)

Project Title: Lysosomal Dysfunction in Childhood-Onset Neurodegeneration: Biochemical Profiling and Genetic Correction of Progranulin Deficiency
PI: Natalia Gomez-Ospina, MD, PhD, Assistant Professor, School of Medicine (Pediatrics)
Co-I: Monther Abu-Remaileh, Assistant Professor, School of Engineering (Chemical Engineering) 

Project Title: Deciphering the Cellular and Molecular Basis of Congenital Arteriovenous Malformations Using Stem Cell-Derived Artery and Vein Endothelial Cells
PI: Kyle M. Loh, PhD, Assistant Professor, School of Humanities & Sciences (Development Biology)
Co-Is: Kristy Red-Horse, Associate Professor, PhD, School of Humanities & Sciences (Biology); Marlene Rabinovitch, MD, Professor, School of Medicine (Pediatrics); Lay Teng Ang, PhD, Instructor, Institute for Stem Cell Biology and Regenerative Medicine  

Project Title: Discovering Adolescents' Smartphone Food Environments
PI: Thomas N. Robinson, MPH, MD, Professor, School of Medicine (Pediatrics)
Co-Is: Byron Reeves, PhD; School of Humanities & Sciences (Communication); Kayvon Fatahalian, PhD; School of Engineering (Computer Science); Maneesh Agrawala, PhD, School of Engineering (Computer Science); Nilam Ram, PhD, School of Humanities and Sciences (Communication and Psychology)

Project Title: Identifying Neurobiological Markers of Autism by Leveraging "Big Data" and Using Deep Learning
PI: Kaustubh Supekar, PhD, The Taube Family Endowed Transdisciplinary Investigator for Maternal Child Health; Clinical Assistant Professor, School of Medicine (Psychiatry & Behavioral Sciences)
Co-Is: Vinod Menon, PhD, Professor, School of Medicine (Psychiatry & Behavioral Sciences); Tengyu Ma, PhD, Assistant Professor, School of Engineering (Computer Science) & School of Humanities & Sciences (Statistics)

2019 Awards

Project Title: Prenatal Predictors of Child Mental Health: Testing a Neurobiological Model of Children’s Risk for Psychopathology
PI: Ian Gotlib, PhD, The Taube Family Endowed Transdisciplinary Investigator for Maternal Child Health,
School of Humanities & Sciences (Psychology)
Co-PI: David K. Stevenson, School of Medicine (Pediatrics)

Project Title: Reversal of Opioid-Induced Neonatal Cardiac Malformation Using CRISPR-Cas9 Gene Editing
PI: Detlef Obal, MD, PhD, DESA, School of Medicine (Anesthesiology, Perioperative & Pain Medicine)
Co-PI: Joseph C. Wu, MD, PhD, School of Medicine (Medicine); Lei (Stanley) Qi, MA, PhD, Schools of Engineering & Medicine (Bioengineering) and School of Medicine (Chemical & Systems Biology)

Project Title: Quantifying Regionalized Care Delivery and Outcomes Using Network Science
PI: Jochen Profit, MD, MPH, School of Medicine (Pediatrics)
Co-PI: Jurij Lesckovec, PhD, School of Engineering (Computer Science)

Project Title: Real-time Biosensor for Treating Type 1 Diabetes in Children
PI: H. Tom Soh, PhD, School of Engineering (Electrical Engineering and Radiology)
Co-PI: Bruce Buckingham, MD, School of Medicine (Pediatrics)

2018 Awards

Project Title: Small Molecules to Inhibit CREB: CBP Interaction for Treatment of Childhood Acute leukemia
PI: Kathleen Sakamoto, MD, PhD, School of Medicine (Pediatrics)
Co-PIs: Soichi Wakatsuki, MD, PhD, SLAC National Accelerator Laboratory; Ron Dror, PhD, School of Engineering (Computer Science); Chaitan Khosla, PhD, School of Engineering (Chemical Engineering and Chemistry)

Project Title: Low-Cost Volumetric Ultrasound Body Scanner for pediatric Patients: Complete Abdominal 3D Imaging without Radiation
PI: Jeremy Dahl, PhD, School of Medicine, Department of Radiology
Co-PIs: Boris Murmann, PhD, School of Engineering (Electrical Engineering); Sebastian Thrun, PhD, School of Engineering (Electrical Engineering); Biondo Biondi, PhD, School of Earth, Energy & Environmental Sciences (Geophysics)
Co-Is: Safwan Halabi, MD, School of Medicine (Radiology); Carl Herickhoff, PhD, School of Medicine (Radiology)

Project Title: Innovative Phenotyping and Theratyping of newborns with Cystic Fibrosis
PI: Carlos Milla, MD, School of Medicine (Pediatrics)
Co-PIs: Jeffrey Wine, PhD, School of Humanities & Sciences (Psychology); Ron Kopito, PhD, School of Humanities & Sciences (Biology)

Project Title: Development of a 3D Model for Human Placental Development to Improve Maternal and Child Health
Co-PIs: Alexander Dunn, PhD, School of Engineering (Chemical Engineering); Katherine Bianco, MD, School of Medicine (Obstetrics & Gynecology)
Co-Is: Roger Pedersen, PhD, School of Medicine (Obstetrics & Gynecology); Virginia Winn, MD, PhD, School of Medicine (Obstetrics & Gynecology); Ruth Lathi, MD, School of Medicine (Obstetrics & Gynecology); Vittorio Sebastiano, PhD, School of Medicine (Obstetrics & Gynecology)

Project Title: Role of mechanical stress in telomere shortening in Duchenne Muscular Dystrophy cardiomyopathy
PI: Helen M. Blau, PhD, Microbiology & Immunology – Baxter Laboratory
Co-PI: Sarah C. Heilshorn, PhD, Materials Science & Engineering

Project Title: Integrated in vitro and in silico models of pulmonary valve dysfunction in children with Tetralogy of Fallot
PI: Alison L. Marsden, PhD, Pediatrics and Bioengineering
Co-PIs: John K. Eaton, PhD, Mechanical Engineering; Doff B. McElhinney, MD, Cardiothoracic Surgery

Project Title: The Health and Well-Being of Children in Immigrant Families
PI: Fernando S. Mendoza, MD, Pediatrics
Co-PIs: Jens Hainmueller, PhD, Political Sciences; David D. Laitin, PhD, Political Sciences; Tomás R. Jiménez, PhD, Sociology; Duncan Lawrence, PhD, Immigration Policy Lab

Project Title: Neurodevelopmental origins and predictors of childhood and adolescent anxiety: a big-data machine learning approach
PI: Vinod Menon, PhD, Psychiatry & Behavioral Sciences
Co-PI: James J. Gross, PhD, Psychology

Project Title: iPSC-Derived Cardiomyocytes to Determine Mechanisms by Which β-Cardiac Myosin Mutations Cause Pediatric Hypertrophic Cardiomyopathy
PI: Daniel Bernstein, MD, Pediatrics
Co-PIs: Beth Pruitt, PhD, Mechanical Engineering; James Spudich, PhD, Biochemistry; Alexander Dunn, PhD, Chemical Engineering

Project Title: Measuring Children’s Physical Activity and Sleep in the Real World: Processing and Analysis of High-Dimensional Accelerometry Data Using Statistical Learning Techniques
PI: Manisha Desai, PhD, Medicine
Co-PIs: Thomas Robinson, MD, Pediatrics; Clete Kushida, MD, PhD, Psychiatry and Behavioral Sciences; Scott Delp, PhD, Bioengineering, Mechanical Engineering & Orthopedic Surgery; Ram Rajagopal, PhD, Civil and Environmental Engineering; Dennis Wall, PhD, Pediatrics

Project Title:  Cerebellar Circuitry in Development, Learning, and Clinical Conditions
PI: Heidi Feldman, MD, PhD, Pediatrics
Co-PIs: Brian Wandell, PhD, Psychology; Bruce McCandliss, PhD, Education; Kristen Yeom, MD, Radiology

Project Title:  The NSD2 methyltransferase in pediatric ALL
PI: Or Gozani, MD, PhD. Biology
Co-PIs: Julien Sage, PhD, Pediatrics and Genetics; Justin Du Bois, PhD, Chemistry; Norman J. Lacayo, MD, Pediatrics

Project Title:  The role of ALDH2 genetic variation and aldehyde metabolism in hematopoietic stem cell biology and the pathogenesis of bone marrow failure
PI: Kenneth Weinberg, MD, Stem Cell Transplantation and Regenerative Medicine
Co-PIs: Daria Mochly-Rosen, PhD, Chemical and Systems Biology; Eric Kool, PhD, Chemistry; Matthew Porteus, MD, PhD, Stem Cell Transplantation and Regenerative Medicine

Project Title: Transforming Growth Factor Beta Induced Protein Promotes Pulmonary Angiogenesis in the Developing Lung by Activating NFκB and Wnt Signaling in the Pulmonary Endothelium
PI: Cristina Alvira, MD, Pediatrics
Co-PIs: Vinicio A. de Jesus Perez, MD, Medicine; Sarah Heilshorn, PhD, Materials Science and Engineering

Project Title: The development and application of novel methodologies for the interpretation of personal genomic data to elucidate the molecular underpinnings of prematurity and bronchopulmonary dysplasia
PI: Gill Bejerano, PhD, Developmental Biology & Computer Science
Co-PIs: Hugh O'Brodovich, MD, Pediatrics; Andrew Ng, PhD, Computer Science; Dmitri Petrov, PhD, Biology

Project Title: Characterizing Blood-Brain Barrier Transport and Brain Tumor Penetration of An Engineered Tumor-Targeting Peptide
PI: Gerald Grant, MD, Neurosurgery
Co-PIs: Jennifer Cochran, PhD, Bioengineering and Chemical Engineering; Edward Graves, PhD, Radiation Oncology; Mark Smith, PhD, Institute for Chemical Biology; Yoon-Jae Cho, MD, Neurology

Project Title: Generation and use of novel glucose-6-phosphate dehydrogenase (G6PD) activators to correct G6PD deficiency; application for neonatal jaundice
PI: Daria Mochly-Rosen, PhD, Chemical and Systems Biology
Co-PIs: Soichi Wakatsuki, PhD, SLAC and Dept of Structural Biology; David Stevenson, MD, Pediatrics

Project Title: The effect of the opportunistic microbes, Aspergillus fumigatus and Pseudomonas aeruginosa, on deterioration of lung function in cystic fibrosis
PI: Jeff Wine, PhD, Psychology
Co-PIs: Richard Moss, MD, Pediatrics; David A. Stevens, MD, Medicine; Alfred Spormann, PhD, Civil & Environmental Engineering

Project Title: Towards Intestinal Stem Cell Transplantation for Pediatric Intestinal Disorders
PI:    Calvin Kuo, MD, PhD, Medicine
Co-PIs:     Andrew Bonham, MD, Transplant Surgery; Sarah Heilshorn, PhD, Materials Engineering; Karl Sylvester, MD, Pediatric Surgery

Project Title: Defining and Managing the Neuropsychological Abnormalities of Myotonic Dystrophy
PI:    John W. Day, MD, PhD, Neurology, Pediatrics
Co-PIs:     Michael Greicius, MD, MPH, Neurology; Brian Wandell, PhD, Psychology

Project Title: Improving the Accuracy of Diagnosing Concussions with Biomechanical and Plasma Biomarkers
PI:    David Carmarillo, PhD, Bioengineering
Co-PIs:    Tony Wyss Coray, MS, PhD, Neurology; Andrew Hoffman, MD, Medicine; Rebecca Shultz, PhD, Orthopedic Surgery

Project Title: Non-invasive MR Imaging Diagnosis of Transplant Rejection
PI:    Heike Daldrup-Link, MD, Radiology
Co-PIs:     Waldo Concepcion, MD, Surgery; Paul Grimm, MD, Pediatrics; Michael Moseley, PhD, Radiology; Dwight Nishimura, PhD, Electrical Engineering