Journal Club 2022-2023

Presenter: Markús Diehl

Presenter’s Lab: Satpathy

Paper Name: Novel antigen presenting cell imparts Treg-dependent tolerance to gut microbiota

Paper Citation: Akagbosu B, Tayyebi Z, Shibu G, Paucar Iza YA, Deep D, Parisotto YF, Fisher L, Pasolli HA, Thevin V, Elmentaite R, Knott M, Hemmers S, Jahn L, Friedrich C, Verter J, Wang ZM, van den Brink M, Gasteiger G, Grünewald TGP, Marie JC, Leslie C, Rudensky AY, Brown CC. Novel antigen presenting cell imparts Treg-dependent tolerance to gut microbiota. Nature. 2022 Sep 7. doi: 10.1038/s41586-022-05309-5. Epub ahead of print. PMID: 36070798.

Link: https://www.nature.com/articles/s41586-022-05309-5 

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Presenter: Gabe Barrón

Presenter’s Lab: Howitt

Paper Name: A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut

Paper Citation: Vergani S, Muleta KG, Da Silva C, Doyle A, Kristiansen TA, Sodini S, Krausse N, Montano G, Kotarsky K, Nakawesi J, Åkerstrand H, Vanhee S, Gupta SL, Bryder D, Agace WW, Lahl K, Yuan J. A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut. Immunity. 2022 Sep 14:S1074-7613(22)00412-5. doi: 10.1016/j.immuni.2022.08.018. Epub ahead of print. PMID: 36115337.

Link: https://www.sciencedirect.com/science/article/pii/S1074761322004125

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Presenter: Izumi de los Rios Kobara, Blish Lab & Gita Abhiraman, Garcia Lab

Paper Name: Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

Paper Citation: Yang C, Jin J, Yang Y, Sun H, Wu L, Shen M, Hong X, Li W, Lu L, Cao D, Wang X, Sun J, Ye Y, Su B, Deng L. Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity. Immunity. 2022 Jul 12;55(7):1268-1283.e9. doi: 10.1016/j.immuni.2022.05.012. Epub 2022 Jun 13. Erratum in: Immunity. 2022 Sep 13;55(9):1747. PMID: 35700739.

Link: https://www.sciencedirect.com/science/article/pii/S1074761322002321?via%3Dihub

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Presenter: Sarah Sackey

Presenter’s Lab: Blish

Paper Name: Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses

Paper Citation: Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010 Dec;11(12):1127-35. doi: 10.1038/ni.1953. Epub 2010 Oct 24. PMID: 20972432; PMCID: PMC2982944.

Link: https://www.nature.com/articles/ni.1953

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Presenter: Jason Nideffer

Presenter’s Lab: Jagannathan and Roncarlo Labs

Paper Name: Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection

Paper Citation: Colaço HG, Barros A, Neves-Costa A, Seixas E, Pedroso D, Velho T, Willmann KL, Faisca P, Grabmann G, Yi HS, Shong M, Benes V, Weis S, Köcher T, Moita LF. Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection. Immunity. 2021 Jan 12;54(1):53-67.e7. doi: 10.1016/j.immuni.2020.09.011. Epub 2020 Oct 14. PMID: 33058782; PMCID: PMC7840524.

Link: https://www.sciencedirect.com/science/article/pii/S1074761320304052?via%3Dihub

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Presenter: Leslie Chan

Presenter’s Lab: Blish Lab

Paper Name: KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

Paper Citation: Li Y, Basar R, Wang G, Liu E, Moyes JS, Li L, Kerbauy LN, Uprety N, Fathi M, Rezvan A, Banerjee PP, Muniz-Feliciano L, Laskowski TJ, Ensley E, Daher M, Shanley M, Mendt M, Acharya S, Liu B, Biederstädt A, Rafei H, Guo X, Melo Garcia L, Lin P, Ang S, Marin D, Chen K, Bover L, Champlin RE, Varadarajan N, Shpall EJ, Rezvani K. KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape. Nat Med. 2022 Oct;28(10):2133-2144. doi: 10.1038/s41591-022-02003-x. Epub 2022 Sep 29. PMID: 36175679.

Link: https://www.nature.com/articles/s41591-022-02003-x

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Democracy Day - No class

Presenter: Anthony Buzzanco, Jardetzky Lab & Preksha Bhagchandani, Kim and Meyer Labs

Paper Name: CD103 fate mapping reveals that  intestinal CD103− tissue-resident memory T cells are the primary responders to secondary infection

Paper Citation: Fung HY, Teryek M, Lemenze AD, Bergsbaken T. CD103 fate mapping reveals that intestinal CD103- tissue-resident memory T cells are the primary responders to secondary infection. Sci Immunol. 2022 Nov 11;7(77):eabl9925. doi: 10.1126/sciimmunol.abl9925. Epub 2022 Nov 4. PMID: 36332012.

Link: https://www.science.org/doi/10.1126/sciimmunol.abl9925

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Thanksgiving - No class

Presenter: Tejas Dharmaraj

Presenter’s Lab: Bollyky

Paper Name: Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function

Paper Citation: Zhang Y, Bailey JT, Xu E, Singh K, Lavaert M, Link VM, D'Souza S, Hafiz A, Cao J, Cao G, Sant'Angelo DB, Sun W, Belkaid Y, Bhandoola A, McGavern DB, Yang Q. Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function. Nat Immunol. 2022 Nov 21. doi: 10.1038/s41590-022-01349-1. Epub ahead of print. PMID: 36411380.

Link: https://www.nature.com/articles/s41590-022-01349-1

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Presenter: Meelad Amouzgar, Bendall Lab & Christie Chang, Satpathy Lab

Paper Name: Systematic single-cell pathway analysis to characterize early T cell activation

Paper Citation: Bibby JA, Agarwal D, Freiwald T, Kunz N, Merle NS, West EE, Singh P, Larochelle A, Chinian F, Mukherjee S, Afzali B, Kemper C, Zhang NR. Systematic single-cell pathway analysis to characterize early T cell activation. Cell Rep. 2022 Nov 22;41(8):111697. doi: 10.1016/j.celrep.2022.111697. PMID: 36417885.

Link: https://www.sciencedirect.com/science/article/pii/S2211124722015716?via%3Dihub

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Presenter: Ben Oberlton

Presenter’s Lab: Bendall

Paper Name: 

Paper Citation: 

Link:

Presenter: Adonis Rubio

Presenter’s Lab: Barnes

Paper Name: Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

Paper Citation: Cohen AA, van Doremalen N, Greaney AJ, Andersen H, Sharma A, Starr TN, Keeffe JR, Fan C, Schulz JE, Gnanapragasam PNP, Kakutani LM, West AP Jr, Saturday G, Lee YE, Gao H, Jette CA, Lewis MG, Tan TK, Townsend AR, Bloom JD, Munster VJ, Bjorkman PJ. Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models. Science. 2022 Aug 5;377(6606):eabq0839. doi: 10.1126/science.abq0839. Epub 2022 Aug 5. PMID: 35857620; PMCID: PMC9273039.

Link: https://www-science-org.stanford.idm.oclc.org/doi/10.1126/science.abq0839

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Presenter: Colin Raposo and Pat Yan

Presenter’s Lab: Satpathy

Paper Name: Flexible and scalable control of T cell memory by a reversible epigenetic switch

Paper Citation: 

Link: https://www.biorxiv.org/content/10.1101/2022.12.31.521782v1.full.pdf

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Presenter: Anthony Francois

Presenter’s Lab: Majeti

Paper Name: CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

Paper Citation: Prokhnevska N, Cardenas MA, Valanparambil RM, Sobierajska E, Barwick BG, Jansen C, Reyes Moon A, Gregorova P, delBalzo L, Greenwald R, Bilen MA, Alemozaffar M, Joshi S, Cimmino C, Larsen C, Master V, Sanda M, Kissick H. CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor. Immunity. 2023 Jan 10;56(1):107-124.e5. doi: 10.1016/j.immuni.2022.12.002. Epub 2022 Dec 28. PMID: 36580918.

Link: https://www.cell.com/immunity/fulltext/S1074-7613(22)00606-9

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Presenter: David Seong

Presenter’s Lab: Idoyaga

Paper Name: Selective STING stimulation in dendritic cells primes antitumor T cell responses

Paper Citation: Jneid B, Bochnakian A, Hoffmann C, Delisle F, Djacoto E, Sirven P, Denizeau J, Sedlik C, Gerber-Ferder Y, Fiore F, Akyol R, Brousse C, Kramer R, Walters I, Carlioz S, Salmon H, Malissen B, Dalod M, Piaggio E, Manel N. Selective STING stimulation in dendritic cells primes antitumor T cell responses. Sci Immunol. 2023 Jan 13;8(79):eabn6612. doi: 10.1126/sciimmunol.abn6612. Epub 2023 Jan 13. PMID: 36638189.

Link: https://www.science.org/doi/10.1126/sciimmunol.abn6612

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Presenter: Alea Delmastro, Angelo and Jagannathan Labs; Potchara Boonrat, Angelo Lab

Paper Name: Pregnancy enables antibody protection against intracellular infection

Paper Citation: Erickson JJ, Archer-Hartmann S, Yarawsky AE, Miller JLC, Seveau S, Shao TY, Severance AL, Miller-Handley H, Wu Y, Pham G, Wasik BR, Parrish CR, Hu YC, Lau JTY, Azadi P, Herr AB, Way SS. Pregnancy enables antibody protection against intracellular infection. Nature. 2022 Jun;606(7915):769-775. doi: 10.1038/s41586-022-04816-9. Epub 2022 Jun 8. PMID: 35676476; PMCID: PMC9233044.

Link: https://www.nature.com/articles/s41586-022-04816-9

Presenter: Azam Mohsin

Presenter’s Lab: Davis

Paper Name: The lung microbiome regulates brain autoimmunity

Paper Citation: Hosang L, Canals RC, van der Flier FJ, Hollensteiner J, Daniel R, Flügel A, Odoardi F. The lung microbiome regulates brain autoimmunity. Nature. 2022 Mar;603(7899):138-144. doi: 10.1038/s41586-022-04427-4. Epub 2022 Feb 23. PMID: 35197636.

Link: https://www.nature.com/articles/s41586-022-04427-4

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Presenter: Karan Kathuria

Lab: Davis

Paper Name: Bacteriophages inhibit andevadecGAS-likeimmune function in bacteria

Paper Citation: Huiting E, Cao X, Ren J, Athukoralage JS, Luo Z, Silas S, An N, Carion H, Zhou Y, Fraser JS, Feng Y, Bondy-Denomy J. Bacteriophages inhibit and evade cGAS-like immune function in bacteria. Cell. 2023 Feb 16;186(4):864-876.e21. doi: 10.1016/j.cell.2022.12.041. Epub 2023 Feb 6. PMID: 36750095; PMCID: PMC9975087.

Link: https://www.sciencedirect.com/science/article/pii/S0092867422015847?via%3Dihub

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Presenter: Vishnu Shankar

Presenter’s Lab: Davis and Mischel

Paper Name: Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis

Paper Citation: Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, Akincilar SC, Tergaonkar V, Shadel GS, Karlseder J. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis. Nature. 2023 Feb;614(7949):767-773. doi: 10.1038/s41586-023-05710-8. Epub 2023 Feb 8. PMID: 36755096; PMCID: PMC9946831.

Link: https://www.nature.com/articles/s41586-023-05710-8

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Presenter: Flora Tierney

Presenter’s Lab: Howitt

Paper Name: Low protease activity in B cell follicles promotes retention of intact antigens after immunization

Paper Citation: Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, Froehle LM, Xiao S, Abraham W, Adams J, Love JC, Huyett P, Kwon DS, Hacohen N, Schief WR, Bhatia SN, Irvine DJ. Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science. 2023 Jan 27;379(6630):eabn8934. doi: 10.1126/science.abn8934. Epub 2023 Jan 27. PMID: 36701450; PMCID: PMC10041875.

Link: https://www.science.org/doi/10.1126/science.abn8934

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Presenter: Chloe Kashiwagi

Presenter’s Lab: Prince and Aghaeepour

Paper Name: Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE

Paper Citation: Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi M. Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Nature. 2023 Feb;614(7948):530-538. doi: 10.1038/s41586-022-05660-7. Epub 2023 Jan 4. PMID: 36599368; PMCID: PMC9945843.

Link: https://www.nature.com/articles/s41586-022-05660-7

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