Journal Club 2020-2021

Seminars & Events

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Li Ka Shing Center (LKSC)

291 Campus Dr
Stanford, CA 94305

Both MCTI and CSI students are required to attend the IMMUNOL 305 Immunology Journal Club for their First through Third years. Attendance is optional for Fourth year and above graduate students.

Journal Club is open to Stanford graduate students, postdocs, and faculty. Please refer to the schedule below. Faculty are encouraged to attend. The paper of the week will continue to be presented by a student; we ask that the presenting student’s advisor make every effort to attend the journal club to facilitate discussion. If your student is presenting, they will contact you about scheduling. Papers will be posted on this page each week.

Fall Quarter: Tuesdays at 3:00-4:00 pm, Online/Video Conference, Contact Julia at jadamska@stanford.edu for log in info.
Winter Quarter: Tuesdays at 3:00-4:00, Online/Video Conference, Contact Erin Soon at erinsoon@stanford.edu for log in info.
Spring Quarter: Tuesdays at 3:00-4:00, Online/Video Conference, Contact Lilit Grigoryan at lilitg@stanford.edu for log in info.

Nov November 17 Tue 2020

Katie Murphy, Mackall Lab
A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin

Wang Y et al. A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin, Immunity (2020), https://doi.org/10.1016/j.immuni.2020.10.009

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Nov November 10 Tue 2020

Jimena Pavlovitch-Bedzyk, Davis Lab
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Rydyznski Moderbacher C, Ramirez SI, Dan JM, et al. Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity. Cell. https://doi.org/10.1016/j.cell.2020.09.038

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Nov November 09 Mon 2020

5:00-6:00 PM
Hayley Raquer, Idoyaga Lab
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Perner et al., Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens, Immunity (2020), https://doi.org/10.1016/j.immuni.2020.10.001

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Nov November 03 Tue 2020

Election Day - Journal Club cancelled

Oct October 27 Tue 2020

Joy Pai, Satpathy Lab
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Galletti G, De Simone G, Mazza EMC, et al. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans [published online ahead of print, 2020 Oct 12]. Nat Immunol. 2020;10.1038/s41590-020-0791-5. doi:10.1038/s41590-020-0791-5

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Oct October 20 Tue 2020

Naomi Haddock, Bollyky Lab
Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

Bedford, J.G., Heinlein, M., Garnham, A.L., Nguyen, T.H.O., Loudovaris, T., Ge, C., ... & Wakim, L.M. (2020). Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes. Science Immunology, 5(52). DOI: 10.1126/sciimmunol.abb5439

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Oct October 13 Tue 2020

Erin Soon, Angelo Lab
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Miragaia, R.J., Gomes, T., Chomka, A., Jardine, L., Riedel, A., Hegazy, A.N., ... & Teichmann, S.A. (2019). Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation. Immunity, 50(2), 493-504.e7. DOI: 10.1016/j.immuni.2019.01.001

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Oct October 06 Tue 2020

Lilit Grigoryan, Pulendran Lab
Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

Kato, Yu et al. "Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo." Immunity vol. 53,3 (2020): 548-563.e8. DOI: 10.1016/j.immuni.2020.08.001

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Sep September 29 Tue 2020

Aaron Wilk, Blish Lab
Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation.

Adrover JM, Aroca-Crevillén A, Crainiciuc G, et al. Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation. Nat Immunol. 2020;21(2):135-44. DOI: 10.1038/s41590-019-0571-2

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Sep September 22 Tue 2020

Candace Liu, Angelo Lab
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Pasciuto, E., Burton, O.T., Roca, C.P., Lagou, V., Rajan, W.D., Theys, T., ... & Liston, A. (2020). Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell, 182(3), 625-640.e24. doi: 10.1016/j.cell.2020.06.026.

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Sep September 15 Tue 2020

Julia Zofia Adamska, Li & Pulendran Labs
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.

Bosteels C, Neyt K, Vanheerswynghels M, et al. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Immunity. 2020;52(6):1039-1056.e9. doi: 10.1016/j.immuni.2020.04.005.

Download article here

Nov November 03 Tue 2020

Hayley Raquer, Idoyaga Lab
Perner et al., Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Perner et al., Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens, Immunity (2020), https://doi.org/10.1016/j.immuni.2020.10.001

Download article here

Nov November 03 Tue 2020

Election Day - Journal Club cancelled

Nov November 03 Tue 2020

Hayley Raquer, Idoyaga Lab
Perner et al., Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Perner et al., Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens, Immunity (2020), https://doi.org/10.1016/j.immuni.2020.10.001

Download article here

Oct October 27 Tue 2020

Joy Pai, Satpathy Lab
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Galletti G, De Simone G, Mazza EMC, et al. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans [published online ahead of print, 2020 Oct 12]. Nat Immunol. 2020;10.1038/s41590-020-0791-5. doi:10.1038/s41590-020-0791-5

Download article here

Oct October 20 Tue 2020

Naomi Haddock, Bollyky Lab
Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

Bedford, J.G., Heinlein, M., Garnham, A.L., Nguyen, T.H.O., Loudovaris, T., Ge, C., ... & Wakim, L.M. (2020). Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes. Science Immunology, 5(52). DOI: 10.1126/sciimmunol.abb5439

Download article here

Oct October 13 Tue 2020

Erin Soon, Angelo Lab
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Miragaia, R.J., Gomes, T., Chomka, A., Jardine, L., Riedel, A., Hegazy, A.N., ... & Teichmann, S.A. (2019). Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation. Immunity, 50(2), 493-504.e7. DOI: 10.1016/j.immuni.2019.01.001

Download article here

Oct October 06 Tue 2020

Lilit Grigoryan, Pulendran Lab
Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

Kato, Yu et al. "Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo." Immunity vol. 53,3 (2020): 548-563.e8. DOI: 10.1016/j.immuni.2020.08.001

Download article here

Sep September 29 Tue 2020

Aaron Wilk, Blish Lab
Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation.

Adrover JM, Aroca-Crevillén A, Crainiciuc G, et al. Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation. Nat Immunol. 2020;21(2):135-44. DOI: 10.1038/s41590-019-0571-2

Download article here

Sep September 22 Tue 2020

Candace Liu, Angelo Lab
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Pasciuto, E., Burton, O.T., Roca, C.P., Lagou, V., Rajan, W.D., Theys, T., ... & Liston, A. (2020). Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell, 182(3), 625-640.e24. doi: 10.1016/j.cell.2020.06.026.

Download article here

Sep September 15 Tue 2020

Julia Zofia Adamska, Li & Pulendran Labs
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.

Bosteels C, Neyt K, Vanheerswynghels M, et al. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Immunity. 2020;52(6):1039-1056.e9. doi: 10.1016/j.immuni.2020.04.005.

Download article here

Jan January 12 Tue 2021

Grayson Rodriguez, Cochran Lab
Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Khaw, Y.M., Majid, D., Oh, S. et al. Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling. Nat Commun 12, 105 (2021). https://doi.org/10.1038/s41467-020

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Jan January 19 Tue 2021

Katherine Nico, Howitt Lab

Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids

Hong, J. Y., Lim, J., Carvalho, F., Cho, J. Y., Vaidyanathan, B., Yu, S., Annicelli, C., Ip, W., & Medzhitov, R. (2020). Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids. Cell, 180(5), 847–861.e15. https://doi.org/10.1016/j.cell.2020.02.018

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Jan January 26 Tue 2021

Frank Buquicchio, Satpathy Lab

BATF3 programs CD8+ T cell memory

Ataide, M.A., Komander, K., Knöpper, K. et al. BATF3 programs CD8+ T cell memory. Nat Immunol 21, 1397–1407 (2020). https://doi-org.stanford.idm.oclc.org/10.1038/s41590-020-0786-2

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Feb February 02 Tue 2021

Valentino Sudaryo, Li Lab

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy

Hao, M., Hou, S., Li, W., Li, K., Xue, L., Hu, Q., Zhu, L., Chen, Y., Sun, H., Ju, C., & Zhang, C. (2020). Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy. Science translational medicine, 12(571), eaaz6667. https://doi.org/10.1126/scitranslmed.aaz6667

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Feb February 09 Tue 2021

Joe Gonzalez, Wang Lab

Diverse viral proteases activate the NLRP1 inflammasome

Tsu, B. V., Beierschmitt, C., Ryan, A. P., Agarwal, R., Mitchell, P. S., & Daugherty, M. D. (2021). Diverse viral proteases activate the NLRP1 inflammasome. eLife, 10, e60609. https://doi.org/10.7554/eLife.60609

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Feb February 16 Tue 2021

Rachel Ee, Bendall Lab

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

Evren, E., Ringqvist, E., Tripathi, K. P., Sleiers, N., Rives, I. C., Alisjahbana, A., Gao, Y., Sarhan, D., Halle, T., Sorini, C., Lepzien, R., Marquardt, N., Michaëlsson, J., Smed-Sörensen, A., Botling, J., Karlsson, M., Villablanca, E. J., & Willinger, T. (2021). Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity, 54(2), 259–275.e7. https://doi.org/10.1016/j.immuni.2020.12.003

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Feb February 23 Tue 2021

Maddie Lee, Blish Lab

NK cells mediate clearance of CD8+ T cell-resistant tumors in response to STING agonists

Nicolai, C. J., Wolf, N., Chang, I. C., Kirn, G., Marcus, A., Ndubaku, C. O., McWhirter, S. M., & Raulet, D. H. (2020). NK cells mediate clearance of CD8+ T cell-resistant tumors in response to STING agonists. Science immunology, 5(45), eaaz2738. https://doi.org/10.1126/sciimmunol.aaz2738

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Mar March 02 Tue 2021

Kalani Ratnasiri, Blish and Khatri Labs

A RUNX–CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes

Murakami, K., Sasaki, H., Nishiyama, A. et al. A RUNX–CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes. Nat Immunol 22, 301–311 (2021). https://doi-org.stanford.idm.oclc.org/10.1038/s41590-021-00871-y

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Mar March 30 Tue 2021

Camilo Espinosa, Aghaeepour Lab

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes

Temba, Godfrey S et al. “Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.” Nature immunology vol. 22,3 (2021): 287-300. doi:10.1038/s41590-021-00867-8

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Apr April 06 Tue 2021

Aaron Trotman-Grant

γδ T cells regulate the intestinal response to nutrient sensing

Sullivan, Zuri A et al. “γδ T cells regulate the intestinal response to nutrient sensing.” Science (New York, N.Y.) vol. 371,6535 (2021): eaba8310. doi:10.1126/science.aba8310

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Apr April 13 Tue 2021

Christie Chang and Meelad Amouzgar, Rotating Labs

Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy

Han, J., Zhao, Y., Shirai, K. et al. Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy. Nat Cancer 2, 300–311 (2021). https://doi.org/10.1038/s43018-021-00180-1

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Apr April 20 Tue 2021

TBA

Apr April 27 Tue 2021

Ben Oberlton and Markus Diehl, Rotating Labs

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

Turner, Jacob A et al. Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity vol. 53,6 (2020): 1202-1214.e6. doi:10.1016/j.immuni.2020.10.002

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May May 04 Tue 2021

Sarah Sackey and Jason Nideffer, Rotating Labs

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Kauffman, Keith D et al. PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques. Science immunology vol. 6,55 (2021): eabf3861. doi:10.1126/sciimmunol.abf3861

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May May 11 Tue 2021

Leslie Chan, Rotating Lab

Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development

Tian, Luyi et al. “Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development.” Immunity, S1074-7613(21)00124-2. 13 Apr. 2021, doi:10.1016/j.immuni.2021.03.012

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May May 18 Tue 2021

Izumi de los Rios Kobara and Gabe Barron, Rotating Labs

Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells

Krueger, Peter D et al. “Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells.” Immunity vol. 54,4 (2021): 687-701.e4. doi:10.1016/j.immuni.2021.03.006

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May May 25 Tue 2021

Gita Abhiraman, Garcia Lab

Targeting monoamine oxidase A for T cell-based cancer immunotherapy

Wang, Xi et al. “Targeting monoamine oxidase A for T cell-based cancer immunotherapy.” Science immunology vol. 6,59 (2021): eabh2383. doi:10.1126/sciimmunol.abh2383

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Jun June 01 Tue 2021

Preksha Bhagchandani, Kim and Meyer Labs

IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage

Cox, Christian B, et al. “IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.” Science immunology vol. 6,59 (2021): eabe8856. doi:10.1126/sciimmunol.abe8856

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