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SCI Innovation Award
October 2024 Awardees
Stanford Cancer Institute Cancer Innovation Award
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Patient-centered discovery science to identify biomarkers of response and define mechanisms of resistance in patients receiving tumor-infiltrating lymphocyte (TIL) cell therapy
Allison Betof Warner, MD, PhD, assistant professor of medicine (oncology), and her collaborator, Zina Good, PhD, instructor, Stanford Institutes of Medicine, received an SCI Cancer Innovation Award.
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Epigenetic-aware deep learning model for single cell-free DNA molecule annotation and cancer classification
Mohammad Esfahani, PhD, assistant professor of radiation oncology (radiation and cancer biology), is the recipient of an SCI Cancer Innovation Award.
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Programmable cancer ablation using RNA sensors for oncogenes
Xiaojing Gao, PhD, assistant professor of chemical engineering, received an SCI Cancer Innovation Award.
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Mega-scaled single cell characterization of CAR-T lenti- and retroviral integration sites
Hanlee Ji, MD, professor of medicine (oncology), and David Miklos, MD, PhD, professor of medicine (bone marrow transplantation and cellular therapy), were awarded an SCI Cancer Innovation Award.
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Functional oncology mapping (FuncOMap) to deliver cutting-edge biomarkers for precision immunotherapy application.
Amanda Kirane, MD, assistant professor of surgery (general surgery) was awarded an SCI Cancer Innovation Award.
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Addressing the acceptability of self-testing kits for prostate cancer screening in South Africa: learning from high-risk communities of men with global implications
Marvin Langston, PhD, MPH, assistant professor of epidemiology and population health, was awarded an SCI Cancer Innovation Award.
SCI Women’s Cancer Center Innovation Award
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Identifying patterns of clinicians delivering guideline-discordant breast cancer care
Allison Kurian, MD, MSc, associate professor of medicine (oncology) and of health research and policy, Jennifer Caswell-Jin, MD, assistant professor of medicine (oncology), and their collaborator, James Dickerson, MD, instructor of medicine (oncology), were awarded an SCI Women's Cancer Center Innovation Award.
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Closing gaps in cancer care disparities by listening to patients' own voices
Eleni Linos, MD, DrPH, MPH, professor of dermatology and of medicine (Center for Digital Health), along with her collaborators, Allison Kurian, MD, MSc, associate professor of medicine (oncology) and of health research and policy, Jennifer Caswell-Jin, MD, assistant professor of medicine (oncology), and Jiyeong Kim, PhD, postdoctoral scholar, dermatology, received an SCI Women's Cancer Center Innovation Award.
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Targeting EPOR positive tumor-associated macrophages in high grade serous ovarian cancer: a novel immunotherapeutic approach
An SCI Women's Cancer Center Innovation Award was awarded to Erinn Rankin, PhD, assistant professor of radiation oncology (radiation biology) and of obstetrics and gynecology (oncology), and Edgar Engleman, MD, professor of pathology and of medicine (immunology and rheumatology).
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Uncovering the role of the type I interferon receptor in cancer metastasis
Nathan Reticker-Flynn, PhD, assistant professor of otolaryngology - head & neck surgery (OHNS) was awarded an SCI Women's Cancer Center Innovation Award.
Shmunis Family Innovation Awards in Cancer Therapeutics
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77Br/18F-hGTS13: a theranostic for detection and targeted treatment of non-small-cell lung cancer
Corinne Beinat, PhD, MSc, assistant professor of radiology (molecular imaging program at Stanford), received a Shmunis Family Innovation Award in Cancer Therapeutics.
Michael Toshio Cure for Cancer Catalyst Award
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Modulation of GVHD through the EPO/EPOR axis
Robert Negrin, MD, professor of medicine (blood and marrow transplantation and cellular therapy), and Edgar Engleman, MD, professor of pathology and of medicine (immunology and rheumatology), received a Michael Toshio Cure for Cancer Catalyst Award.
Prior Awardees
SCI Innovation Awards
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Label-free spatial profiling of the tumor microenvironment for therapeutic prediction
An SCI Innovation Award was given to Amanda Kirane, MD, assistant professor of surgery (general surgery) and Jennifer Dionne, PhD, associate professor of materials science and engineering for their proposal titled “Label-free spatial profiling of the tumor microenvironment for therapeutic prediction.”
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Integration of MR perfusion and metabolic imaging biomarkers with circulating EBV-DNA for predicting treatment response and prognostication in patients with nasopharyngeal cancer
Nancy Pham, MD, clinical assistant professor, radiology, Quynh-Thu Le, MD, Katharine Dexter McCormick and Stanley McCormick Memorial Professor, Dimitrios Colevas, MD, professor of medicine (oncology), Nancy Fischbein, MD, professor of radiology, and Michael Iv, MD, clinical associate professor, radiology, have been granted an SCI Innovation Award for their project, “Integration of MR perfusion and metabolic imaging biomarkers with circulating EBV-DNA for predicting treatment response and prognostication in patients with nasopharyngeal cancer.”
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A platform for elucidating the tumor-reactive T cell repertoire of metastatic cancers
An SCI Innovation Award was given to Nathan Reticker-Flynn, PhD, assistant professor of otolaryngology - head & neck surgery, for his proposal, “A platform for elucidating the tumor-reactive T cell repertoire of metastatic cancers.”
SCI Nodal Award
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Deconstructing tumor-immune landscape of GBM using engineered 3D assembloids
Melanie Hayden Gephart, MD, MAS, professor of neurosurgery, Marius Wernig, MD, PhD, professor of pathology, and Michael Bassik, PhD, associate professor of genetics were awarded an SCI Nodal Award for their proposal titled “Deconstructing tumor-immune landscape of GBM using engineered 3D assembloids.”
SCI Pancreatic Cancer Innovation Award
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Rewiring RAS pathway mutations to activate programmed cell death in pancreatic cancer
Gerald Crabtree, MD, David Korn, MD, Professor of Pathology and professor of developmental biology, and Nathanael Gray, PhD, Krishnan-Shah Family Professor of chemical and systems biology, were awarded an SCI Pancreatic Cancer Innovation Award for their project, “Rewiring RAS pathway mutations to activate programmed cell death in pancreatic cancer.”
SCI Women’s Cancer Center Innovation Award
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Detection & prevention of severe dose-limiting neurotoxicity among adults initiating breast cancer treatment
Alyce Adams, PhD, Stanford Medicine Innovation Professor and professor of health policy, epidemiology and population health, and Miriam Goodman, PhD, Mrs. George A. Winzer Professor of Cell Biology, were awarded an SCI Women’s Cancer Center Innovation Award for their proposal, “Detection & prevention of severe dose-limiting neurotoxicity among adults initiating breast cancer treatment: an interdisciplinary proof of concept study.”
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Engineering target receptors to boost efficacy of antibody-drug conjugate therapy
Carolyn Bertozzi, PhD, Baker Family Director of Sarafan ChEM-H, Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences, received an SCI Women’s Cancer Center Innovation Award for her proposal entitled “Engineering target receptors to boost efficacy of antibody-drug conjugate therapy.”
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GPR65 expression, obesity, and breast cancer in a multiethnic population
An SCI Women’s Cancer Center Innovation Award was awarded to Esther M. John, PhD, professor (research) of epidemiology and population health and of medicine (oncology), and Edgar Engleman, MD, professor of pathology and of medicine (immunology and rheumatology), for their proposal, “GPR65 expression, obesity, and breast cancer in a multiethnic population.”
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Investigating DCIS progression via 3D volumetric imaging and single-cell spatial-omics
Garry Nolan, PhD, Rachford and Carlota Harris Professor, received an SCI Women’s Cancer Center Innovation Award for his proposal titled “Investigating DCIS progression via 3D volumetric imaging and single-cell spatial-omics.”
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Novel approaches for creating fallopian tube organoids with BRCA1/2 heterozygous mutations
Bo Yu, MD, MS, assistant professor of obstetrics and gynecology (reproductive endocrinology and infertility) was awarded an SCI Women’s Cancer Center Innovation Award for her proposal, “Novel approaches for creating fallopian tube organoids with BRCA1/2 heterozygous mutations.”
Behar Innovation Award in Sarcoma Research
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High-resolution longitudinal analysis of sarcoma response to hypofractionated radiotherapy
Everett Moding, MD, PhD, assistant professor of radiation oncology (radiation therapy), was awarded a Behar Innovation Award in Sarcoma Research for his project, “High-resolution longitudinal analysis of sarcoma response to hypofractionated radiotherapy.”
SCI Innovation Award
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Degron-controlled base editors for massively scalable gene variant screens
A $50,000 SCI Women's Cancer Center Innovation Award was awarded to Paul Blumenthal, MD, MPH, professor of obstetrics and gynecology, and his co-investigators Emily McClung, MD, clinical assistant professor of obstetrics & gynecology, and Michelle Khan, MD, MPH, clinical associate professor of obstetrics & gynecology, for their proposal entitled “Innovating for treatment of cervical pre-cancer: Novel use and application of trichoroacetic acid (TCA) to treat cervical dysplasia with an ultimate focus on low-resource settings.”
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High-throughput engineering of receptors and signaling adapters to program anti-tumor macrophages
A $50,000 SCI Women's Cancer Center Innovation Award was awarded to Paul Blumenthal, MD, MPH, professor of obstetrics and gynecology, and his co-investigators Emily McClung, MD, clinical assistant professor of obstetrics & gynecology, and Michelle Khan, MD, MPH, clinical associate professor of obstetrics & gynecology, for their proposal entitled “Innovating for treatment of cervical pre-cancer: Novel use and application of trichoroacetic acid (TCA) to treat cervical dysplasia with an ultimate focus on low-resource settings.”
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Elucidating mechanisms of lymph node metastatic tolerance in high-risk resectable cholangiocarcinoma
A $50,000 SCI Innovation Award was awarded to Lipika Goyal, MD, associate professor of medicine (oncology), Edgar Engleman, MD, professor of pathology and of medicine (immunology and rheumatology), Daniel Delitto, MD, PhD, assistant professor of surgery (general surgery), and Gregory Charville, PhD, assistant professor of pathology, for their proposal titled “Elucidating mechanisms of lymph node metastatic tolerance in high-risk resectable cholangiocarcinoma.”
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Regulation of mRNA 3’ end formation by recurrent RNA splicing factor mutations
A $50,000 SCI Women's Cancer Center Innovation Award was awarded to Fauzia Riaz, MD, clinical assistant professor of medicine (oncology), and Candice Thompson, MD, clinical assistant professor of surgery, and their collaborator Melinda Telli, MD, associate professor of medicine (oncology), for their proposal “Circulating tumor-DNA detection in early stage triple negative and HER2-positive breast cancer.”
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Co-design of an educational intervention for melanoma prevention and awareness for teens
A $50,000 SCI Innovation Award was awarded to Dawn Siegel, MD, clinical professor of dermatology, and Albert Chiou, MD, MBA, clinical associate professor of dermatology, for their proposal titled “Co-design of an educational intervention for melanoma prevention and awareness for teens.”
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A synthetic GPCR platform for cell-based cancer therapy
Alice Ting, PhD, professor of genetics, of biology, was awarded a $50,000 SCI Innovation Award for her proposal “A synthetic GPCR platform for cell-based cancer therapy.”
SCI Pancreatic Cancer Innovation Awards
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Claudin-4-targeted imaging and readiothergnostics to treat pancreatic cancer
A $50,000 SCI Pancreatic Cancer Innovation Award was awarded to Katherine Ferrara, PhD, professor of radiology, for her proposal “Claudin-4-targeted imaging and readiothergnostics to treat pancreatic cancer.”
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Engineering of personalized medicine organoids for pancreatic ductal adenocarcinoma
Sarah Heilshorn, PhD, director of the Geballe Laboratory for Advanced Materials (GLAM), professor of materials science and engineering, Calvin Kuo, MD, PhD, Maureen Lyles D'Ambrogio Professor, and Christina Curtis, PhD, professor of medicine (oncology) and of genetics, were awarded a $50,000 SCI Pancreatic Cancer Innovation Award for their proposal “Engineering of personalized medicine organoids for pancreatic ductal adenocarcinoma.”
SCI Women's Cancer Center Innovation Awards
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The microbiome as a modulator of immunotherapy treatment response in triple negative breast cancer
Ami Bhatt, MD, PhD, associate professor of medicine (hematology) and of genetics, and her co-investigator, Allison Kurian, MD, MSc, associate professor of medicine (oncology) and of health research and policy, were awarded a $50,000 SCI Women's Cancer Center Innovation Award. Their proposal is titled “The microbiome as a modulator of immunotherapy treatment response in triple negative breast cancer.”
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Innovating for treatment of cervical pre-cancer: Novel use and application of trichoroacetic acid (TCA) to treat cervical dysplasia with an ultimate focus on low-resource settings
A $50,000 SCI Women's Cancer Center Innovation Award was awarded to Paul Blumenthal, MD, MPH, professor of obstetrics and gynecology, and his co-investigators Emily McClung, MD, clinical assistant professor of obstetrics & gynecology, and Michelle Khan, MD, MPH, clinical associate professor of obstetrics & gynecology, for their proposal entitled “Innovating for treatment of cervical pre-cancer: Novel use and application of trichoroacetic acid (TCA) to treat cervical dysplasia with an ultimate focus on low-resource settings.”
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Reprogramming lymphocyte migration to overcome immune exclusion in breast cancer – towards cell therapies with spatial specificity
Livnat Jerby, PhD, Assistant Professor of Genetics, was awarded a $50,000 SCI Women's Cancer Center Innovation Award for her proposal “Reprogramming lymphocyte migration to overcome immune exclusion in breast cancer – towards cell therapies with spatial specificity.”
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Treatment of breast cancer through reversal of bacteria-induced neutrophil-mediated immunosuppression
Derick Okwan, MD, PhD, assistant professor of pathology, and his co-investigator Edgar Engleman, MD, professor of pathology and of medicine (immunology and rheumatology), were awarded a $50,000 SCI Women's Cancer Center Innovation Award for their proposal “Treatment of breast cancer through reversal of bacteria-induced neutrophil-mediated immunosuppression.”
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Circulating tumor-DNA detection in early stage triple negative and HER2-positive breast cancer
A $50,000 SCI Women's Cancer Center Innovation Award was awarded to Fauzia Riaz, MD, clinical assistant professor of medicine (oncology), and Candice Thompson, MD, clinical assistant professor of surgery, and their collaborator Melinda Telli, MD, associate professor of medicine (oncology), for their proposal “Circulating tumor-DNA detection in early stage triple negative and HER2-positive breast cancer.”
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Biology-aware deep learning for prediction of outcome of cancer immunotherapy with immune checkpoint inhibitors
Lei Xing, PhD, Jacob Haimson and Sarah S. Donaldson Professor, James Zou, PhD, assistant professor of biomedical data science, and Max Diehn, MD, PhD, professor of radiation oncology, were awarded a $50,000 SCI Women's Cancer Center Innovation Award for their proposal “Biology-aware deep learning for prediction of outcome of cancer immunotherapy with immune checkpoint inhibitors.”
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Systematic pan-cancer analysis of sex dimorphism in response to treatments using large real-world clinicogenomics data
A $50,000 SCI Women's Cancer Center Innovation Award was awarded to James Zou, PhD, assistant professor of biomedical data science for his proposal titled “Systematic pan-cancer analysis of sex dimorphism in response to treatments using large real-world clinicogenomics data.”
Shmunis Family Innovation Awards in Cancer Therapeutics
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From inhibition to activation: A novel siglec-based strategy for cancer immunotherapy
Carolyn Bertozzi, PhD, Baker Family Director of Stanford ChEM-H, Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences, was awarded a $50,000 Shmunis Family Innovation Award in Cancer Therapeutics for her project entitled “From inhibition to activation: A novel siglec-based strategy for cancer immunotherapy.”
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Targeting hyperactive mTORC2 in lung cancer
Kacper Rogala, PhD, assistant professor of structural biology and of chemical and systems biology, was awarded a $50,000 Shmunis Family Innovation Award in Cancer Therapeutics for his proposal titled “Targeting hyperactive mTORC2 in lung cancer.”
Behar Innovation Award in Sarcoma Research
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Immunotherapeutic targeting of fusion oncogenes in sarcoma
Anusha Kalbasi, MD, associate professor of radiation oncology, was awarded a $50,000 Behar Innovation Award in Sarcoma Research for his proposal titled “Immunotherapeutic targeting of fusion oncogenes in sarcoma.”
SCI Nodal Award
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Using digital phenotyping to optimize psychosocial risk screening and personalized care: a pilot study in adolescents and young adults with cancer.
A $50,000 SCI Nodal Grant award was awarded to Victoria Cosgrove, PhD, Clinical Associate Professor of Psychiatry and Behavioral Sciences, and Catherine Benedict, PhD, Clinical Assistant Professor, Psychiatry and Behavioral Sciences, and collaborator Tanja Gruber, MD, PhD, Chambers Family Endowed Professor for Pediatric Cancer, Pediatrics-Hematology and Oncology, for their project entitled “Using digital phenotyping to optimize psychosocial risk screening and personalized care: a pilot study in adolescents and young adults with cancer.”
SCI Innovation Awards
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Cone beam CT-guided, electromagnetic bronchoscopy-aided delivery of high dose rate brachytherapy for peripheral lung mass ablation
A $50,000 SCI Cancer Innovation award was awarded to Wu Liu, PhD, Associate Professor of Radiation Oncology; Billy W. Loo Jr., MD, PhD, Professor of Radiation Oncology; and Harmeet Bedi, MD, Clinical Assistant Professor of Medicine, for their project entitled “Cone beam CT-guided, electromagnetic bronchoscopy-aided delivery of high dose rate brachytherapy for peripheral lung mass ablation.”
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Promoting nutrition security among colorectal cancer survivors
Lisa Goldman Rosas, PhD, MPH, Assistant Professor of Epidemiology and Population Health and of Medicine, was awarded a $50,000 SCI Innovation award for her project entitled “Promoting nutrition security among colorectal cancer survivors.” Dr. Goldman Rosas’ research focuses on addressing disparities in chronic diseases and cancer among racial/ethnic minority families.
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Inventing a noninvasive way to detect measurable residual disease (MRD) in acute myeloid leukemia (AML) using circulating tumor DNA (ctDNA)
A $50,000 SCI Innovation award was awarded to Tian Yi Zhang, MD, PhD, Assistant Professor of Medicine, and her collaborator David Kurtz, MD, PhD, Assistant Professor of Medicine (Oncology), for their project entitled “Inventing a noninvasive way to detect measurable residual disease (MRD) in acute myeloid leukemia (AML) using circulating tumor DNA (ctDNA).”
SCI Pancreatic Cancer Innovation Awards
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Inserting a switch into IL-2 to develop PD-1-dependent immunotherapy
A $50,000 Stanford Women's Cancer Center Innovation award was awarded to Danny Chou, PhD, Assistant Professor of Pediatrics and, by courtesy, of Chemical and Systems Biology, and his collaborator Everett Meyer, MD, PhD, Associate Professor of Medicine, for their project entitled “Inserting a switch into IL-2 to develop PD-1-dependent immunotherapy.”
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Can changing cancer mindsets improve biomarkers of immune functioning?
A $50,000 Stanford Women's Cancer Center Innovation award was awarded to Alia Crum, PhD, Associate Professor of Psychology and, by courtesy, of Medicine; Lidia Schapira, MD, Professor of Medicine (Oncology); Michael Snyder, PhD, Stanford W. Ascherman Professor of Genetics; and David Spiegel, MD, PhD, Jack, Lulu, and Sam Willson Professor of Medicine, Psychiatry and Behavioral Sciences, for their project entitled “Can changing cancer mindsets improve biomarkers of immune functioning? Piloting the effects of a novel digital intervention on direct-to-patient blood sampling and multiomics profiling.”
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Feasibility of community based same day cervical cancer screening for refuge women in Tijuana, Mexico
A $50,000 Stanford Women's Cancer Center Innovation award was awarded to Kay Daniels, MD, Clinical Professor, Obstetrics and Gynecology, and Paul Blumenthal, MD, MPH, Professor of Obstetrics and Gynecology, for their project entitled “Feasibility of community based same day cervical cancer screening for refuge women in Tijuana, Mexico.”
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Novel strategies to improve ovarian cancer sensitivity to immunotherapy
Oliver Dorigo, MD, PhD, Associate Professor of Obstetrics and Gynecology (Oncology), was awarded a $50,000 Stanford Women's Cancer Center Innovation award for his project entitled “Novel strategies to improve ovarian cancer sensitivity to immunotherapy.”
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Disparities in second primary breast cancer and inflammatory biomarkers
A $50,000 Stanford Women's Cancer Center Innovation award was awarded to Esther John, PhD, MSPH, Professor of Epidemiology and Population Health and of Medicine, and her collaborators, Allison Kurian, MD, Professor of Medicine (Oncology) and of Epidemiology and Population Health, and Holden Maecker, PhD, Professor of Microbiology and Immunology, for their project entitled “Disparities in second primary breast cancer and inflammatory biomarkers.”
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The impact of multiraciality, comorbidity, and geography on cancer disparities among the Native Hawaiian and Other Pacific Islander Population in the United States
A $50,000 Stanford Women's Cancer Center Innovation award was awarded to Erqi Pollom, MD, Associate Professor of Radiation Oncology and, by courtesy, of Neurosurgery, and her collaborators Manali Patel, MD, Assistant Professor of Medicine (Oncology), and Kekoa Taparra, MD, PhD, resident physician-scientist trainee in the Department of Radiation Oncology, for their project entitled “The impact of multiraciality, comorbidity, and geography on cancer disparities among the Native Hawaiian and Other Pacific Islander Population in the United States.”
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Volume and Symmetry Outcomes in Unilateral Omentum-based Breast Reconstruction
A $50,000 Stanford Women's Cancer Center Innovation award was awarded to Irene Wapnir, MD, Professor of Surgery, and her collaborator Dung Nguyen, MD, Pharm. D, Clinical Professor of Plastic & Reconstructive Surgery, for their project entitled “Volume and symmetry outcomes in unilateral omentum-based breast reconstruction.”
Shmunis Family Innovation Awards in Cancer Therapeutics
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Harnessing an E3 ligase for pancreatic cancer therapy
Steven Corsello, MD, Assistant Professor of Medicine (Oncology), was awarded a $50,000 Shmunis Family Innovation Awards in Cancer Therapeutics award for his project entitled “Harnessing an E3 ligase for pancreatic cancer therapy.”
Behar Innovation Award in Sarcoma Research
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Identifying novel therapeutic targets in liposarcoma
Jonathan Pollack, MD, PhD, Professor of Pathology, was awarded a $50,000 Behar Innovation Awards in Sarcoma Research award for his project entitled “Identifying novel therapeutic targets in liposarcoma.”