SCI Innovation Awards

SCI Nodal Award

• Victoria Cosgrove, PhD; Catherine Benedict, PhD; Tanja Gruber, MD, PhD
  Assessing Pancreatic Adenocarcinoma Intratumoral Microbiome to Develop a Biomarker Predictive of Long-term Outcomes and Response to Chemotherapy

SCI Innovation Awards 

• Wu Liu, PhD; Billy W. Loo Jr., MD, PhD; Harmeet Bedi, MD
  Cone beam CT-guided, electromagnetic bronchoscopy-aided delivery of high dose rate brachytherapy for peripheral lung mass ablation
• Lisa Goldman Rosas, PhD, MPH
  Promoting Nutrition Security Among Colorectal Cancer Survivors
• Tian Yi Zhang, MD, PhD; David Kurtz, MD, PhD
  Inventing a noninvasive way to detect measurable residual disease (MRD) in acute myeloid leukemia (AML) using circulating tumor DNA (ctDNA)

SCI Pancreatic Cancer Innovation Awards

• Laura Attardi, PhD; Jin Li, PhD
  Targeting Adar1 to overcome pancreatic cancer resistance to immune checkpoint blockade
• Xiaojing Gao, PhD
  Enhance the Precision of Adoptive Cell Therapy Using Modular, Post-Transcriptional Synthetic Receptors
• George Poultsides, MD, MS, FACS; Niaz Banaei, MD
  Assessing Pancreatic Adenocarcinoma Intratumoral Microbiome to Develop a Biomarker Predictive of Long-term Outcomes and Response to Chemotherapy

SCI Women’s Cancer Center Innovation Award

• Danny Chou, PhD; Everett Meyer, MD, PhD
  Inserting a switch into IL-2 to develop PD-1-dependent immunotherapy
• Alia Crum, PhD; Lidia Schapira, MD; David Spiegel, MD PhD; Michael Snyder, PhD
  Can Changing Cancer Mindsets Improve Biomarkers of Immune Functioning? Piloting the Effects of a Novel Digital Intervention on Direct-to-Patient Blood Sampling and Multiomics Profiling
• Kay Daniels, MD; Paul D. Blumenthal, MD, MPH
  Feasibility of community based same day cervical cancer screening for refuge women in Tijuana, Mexico
• Oliver Dorigo, MD, PhD
  Novel strategies to improve ovarian cancer sensitivity to immunotherapy
• Esther John, PhD; Allison Kurian, MD, MSc; Holden Maecker, PhD
  Disparities in second primary breast cancer and inflammatory biomarkers
• Erqi Pollom, MD; Manali Patel, MD, MS; Kekoa Taparra, MD, PhD
  The impact of Multiraciality, Comorbidity, and Geography on Cancer Disparities Among the Native Hawaiian and Other Pacific Islander Population in the United States
• Irene Wapnir, MD; Dung Nguyen, MD, Pharm D
  Volume and Symmetry Outcomes in Unilateral Omentum-based Breast Reconstruction

Shmunis Family Innovation Awards in Cancer Therapeutics

• Steven Corsello, MD
  Harnessing an E3 ligase for pancreatic cancer therapy

Behar Innovation Award in Sarcoma Research

• Jonathan Pollack, MD, PhD
  Identifying novel therapeutic targets in liposarcoma
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SCI Cancer Innovation Award

• “Targeting Human Breast Cancer Metastases by a Novel Therapeutic Antibody” Shoshana Levy, PhD
• “Engineering Next-generation Breast Cancer Cell Therapies: Targeting HER2 heterogeneity” Rogelio Hernandez-Lopez, PhD
• “Neoadjuvant Pembrolizumab Cetuximab for Locally Advanced Betel Nut Induced Oral Cavity Cancer (NEOCORAL) Phase II Clinical Trial” Quynh Le, MD
• "In Vivo Modeling of the Tumor Mutational Load and its Effect on Tumor Suppression and Response to Therapy" Dmitri Petrov, PhD; Monte Winslow, PhD

Under One Umbrella - Women’s Cancer Center Innovation Award

• "Faster is Better: Artificial Intelligence Optimized Cervical Cancer Brachytherapy Treatment Customization" Elizabeth Kidd, MD; Thomas Niedermayr, PhD
• "Establishing a Fallopian Tube Organoid System to Investigate Potential Pathogens in Ovarian Cancer” Bo Yu, MD

SCI Cancer Innovation Award

• “ALCANCE Food for Health Equity” Patel, Manali; Goldman Rosas, Lisa
• “Community Partnerships to Improve Cancer Survivorship Care for Adolescents/Young Adults in the San Joaquin Valley” Schapira, Lidia; Smith, Stephanie
• “Multi-Tracer PET imaging for Prostate Cancer Detection Using Context-Aware Generative Models from a single PET” Levin, Craig
• "Median Survival to Life Expectancy: How Cancer Trial-Reported Outcomes Relate to Clinical Benefit, Population Health, and Health Equity " Goldhaber-Fiebert, Jeremy; Owens, Doug; Caswell-Jim, Jennifer

Stanford Women’s Cancer Center Innovation Award

• "Leveraging image-based sequencing to dissect multicellular regulation in ovarian cancer" Jerby, Livnat; Howitt, Brooke
• "Tumor Infiltrating Lymphocytes and Breast Cancer Mortality in Racially/Ethnically Diverse Participants of the Northern California Breast Cancer Family Registry” Telli, Melinda; John, Esther
• “Live cell imaging of the cytoskeleton during NK and ovarian tumor cell trogocytosis” Fantl, Wendy; Jackson, Peter
• "Modeling endometrial cancer using genetically engineered primary organoids"  Kuo, Calvin

SCI Nodal Grant Award

• “Bioengineering antibodies with phage display to overcome T cell exhaustion in tumors” Lim, Michael; Cochran, Jennifer
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SCI Cancer Innovation Award

• “A Multi-tiered Genomic and Transcriptomic Predictor of Response to Immunotherapy in Sarcomas” Nam Bui, MD (Everett Moding, MD, PhD)
• “Which Men Benefit From Prostate Cancer Screening? A Machine Learning-Enhanced Regression Discontinuity Analysis to Identify Heterogeneous Treatment Effects in Stanford's and National Cancer Patient Cohorts” Tina Hernandez-Boussard, MD, PhD
• “A Novel Approach to Enhance the Potency and Specificity of CAR T Cells for Solid Tumors” Robbie Majzner, MD
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SCI Pancreatic Cancer Innovation Award

• “A Conceptually New Approach to NET-Targeted Chemotherapeutic Delivery” Justin Annes, MD, PhD
• “Targeting Pancreatic Cancer with ALDH1B1 Antagonists” James Chen, PhD
• “Synthetic-Circuit-Mediated Immunotherapy Against KRAS-Driven Pancreatic Cancer” Xiaojing Gao, PhD
• “Deciphering the Impact of Neoadjuvant Chemotherapy on the Antitumor Immunity and Antibody Delivery in Pancreatic Cancer Patients Using Single-Cell Spatial Mapping” George Poultside, MD (George Fisher, MD)
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Stanford Women’s Cancer Center Innovation Award

• "Comprehensive Molecular Profiling of Primary Angiosarcomas and Hemangiomas of the Breast to Aide in Diagnosis and Treatment" Gregory Bean, MD, PhD
• "Preclinical Model for Evaluating FLASH Radiotherapy for Breast Cancer” Frederick Dirbas, MD (Ted Graves, PhD; Kathleen Horst, MD; Bill Loo, MD, PhD)
• “Differential Compartmentalization of the Actin-Binding Protein CapG Increases Breast and Ovarian Cancer Cell Invasiveness” Oliver Dorigo, MD, PhD
• "Revealing the Potential for mSWI/SNF as Biomarkers in Breast Cancers"  Capucine Van Rechem, PhD
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SCI Nodal Grant Award

• “Impact of COVID-19 on Cancer-Directed Management and Outcomes.” Sumit Shah, MD, PhD
• “Determining and Targeting Mechanisms Controlling Cancer Cell Division” Jan Skotheim, PhD (Julien Sage, PhD)
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SCI Cancer Innovation Award

• “Synergizing CAR-T Cell Therapy with Radiation for the Treatment of Brain Tumors.” Edward Graves, PhD
• “Universal Sterilization of Blood Products through Next-Generation Ultra-High Dose Rate Linear Accelerator Irradiation.” Tho D. Pham, MD; Bill Loo, MD, PhD; Edward Graves, PhD; Sami Tantawi, PhD
• “A New Mechanism for Checkpoint Inhibition.” Christopher Garcia, PhD
• “Defining the Relationship Between Somatic Symptoms and Fear of Cancer Recurrence to Improve Health Outcomes for Young Female Cancer Survivors: A Pilot Study.” Lidia Schapira, MD
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SCI Pancreatic Cancer Innovation Award

• “Investigation of the Epigenetic Enzyme NSD2 as a Therapeutic Target in Pancreatic Cancer.” OrGozani, MD, PhD
• “Development of a More Effective KRAS-Based Vaccine for the Treatment of Pancreatic Cancer.” Albert J. Wong, MD
• “Pancreatic Cancer Treatment by Disrupting Total EGFR Signaling Through AGR2 Inhibition.” Anson Lowe, MD
• “Evaluating Treatment Trends, Care Fragmentation and Outcomes for Pancreatic Cancer in California.” Brendan C. Visser, MD
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Stanford Women’s Cancer Center Innovation Award

• "Identification of Critical Drivers in High Risk of Relapse Estrogen Receptor-Positive Patient-Derived Breast Cancer Organoids Using CRISPRi/a Screens" Christina Curtis, PhD; Michael Bassik, PhD
• "Development of a Multi-omic Liquid Biopsy Assay for the Pre-operative Diagnosis of Uterine SmoothMuscle Tumors.” Matt van de Rijn, MD, PhD
• “Tubal Origin of High-Grade Serous Carcinoma: A Closer Look at Early Events in Pathogenesis.” Brooke Howitt, MD
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SCI Nodal Grant Award

• “Integrated Sensor and Omics Monitoring to Evaluate CAR-T Adverse Events.” Surbhi Sidana, MD
• “Elucidating Autoimmunityin Patients with Thymic Epithelial Tumors.” Sukhmani Padda, MD; Kenneth Weinberg, MD; Joseph P. Shrager, MD; William Robinson, MD, PhD
• “Expanding the Reach of the Stanford Brain Metastases Consortium: Deep Profiling of Brain Metastases through Multiplexed Analysis and Multi-PI Collaborations.” Melanie Hayden Gephart, MD
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SCI Cancer Innovation Award

• “Uncovering the oxaliplatin mechanism of action”; Onn Brandman, PhD
• “Development and Evaluation of the Healthy Futures Module: A Community Resource for Youth Tobacco/Vaping Cessation”; Bonnie Halpern-Felsher, PhD
• “A federated deep learning system for AI cancer evaluation”; Daniel Rubin, MD, MS
• “Quality of life, Cognitive Functioning, Access to Care and Financial Burden in Patients Receiving Chimeric Antigen Receptor T Cell Therapy”; Surbhi Sidana, MD,  Lori Muffly, MD, MS, Llana Yurkiewicz, MD
• “Assessment of Molecular Response and Genomic Selection During Therapy with Chimeric Antigen Receptor T-cells from Circulating Tumor DNA” ; Brian Sworder, MD, PhD, Ash Alizadeh, MD, PhD, David Kurtz, MD, PhD

SCI Pancreatic Cancer Innovation Award

• “The molecular basis of metabolic rewiring in pancreatic ductal adenocarcinoma”; Monther Abu-Remaileh, PhD
• “ZDHHC5: a New Candidate Target for Pancreatic Cancer”; Scott Dixon, PhD

Stanford Women’s Cancer Center Innovation Award

• “Integrative Systems analysis of BRCA-mutant and BRCA-wild type HGSC tumors”; Wendy Fantl, PhD,  Brooke Howitt, MD, Andrew Gentles, PhD
• “Addressing mental health disparities among Latina breast cancer patients”; Lisa Goldman Rosas, PhD, MPH,  Maria Juarez-Reyes, MD, PhD
• “Anti-VISTA immunotherapy for metastatic triple-negative breast cancer”; Joshua Gruber, MD, PhD, Melinda Telli, MD
• “Phase I dose finding and image characterization study introducing novel use of GCSF and FDG-PET to individualize bone marrow sparing radiotherapy for gynecologic cancer”; Elizabeth Kidd, MD, Dimitre Hristov, PhD
• “Optimizing Innovative Retention Strategies for Randomized Clinical Trials of Women's Cancers” ; Michaela Kiernan, PhD

SCI Nodal Grant Award

“Head and Neck Cancer SPORE Application Planning Grant”; John Sunwoo, MD, MA, Quynh-Thu Le, MD

SCI Cancer Innovation Award

• “Reprogramming Cancer Cells into Antigen Presenting Cells for Cancer Vaccination”; Ravi Majeti, MD, PhD; Paul Wender, PhD; Bob Weymouth, PhD
• “Identification of Genetic Mutations in Patients With Multiple Primary Melanomas”; Kavita Sarin, MD, PhD; Susan Swetter, MD; Justin Ko, MD, MBA; Shaundra Eichstadt, MD
• “Pilot study to improve survivorship care related to fertility and family-building after cancer”; Catherine Benedict, PhD; Lidia Schapira, MD; David Spiegel, MD; Jonathan Berek, MD; Allison Kurian, MD; Rubin Alvero, MD; Pamela Simon, NP
• “A Surgical Window of Opportunity Trial Evaluating a Single Dose of Dostarlimab (Anti-PD-1) on Gestational Trophoblastic Neoplasia as a Model of Immune Marker Response”; Elisabeth Diver, MD

SCI Pancreatic Cancer Innovation Award

•  “Early detection of pancreas cancers through multi-omic circulating tumor DNA profiling”; Daniel King, MD, PhD; Ash Alizadeh, MD, PhD      
• “Development of a novel immunocompetent and physiologically-relevant mouse model for human pancreatic cancer”; Hiro Nakauchi, MD, PhD     

Stanford Women’s Cancer Center Innovation Award

• “Profiling and Optimizing Ovarian Cancer Immunotherapy Responses in Patient-Derived Organoid Cultures”; Calvin Kuo, MD, PhD; Brooke Howitt, MD; Amer Karam, MD
•  “Soluble CA-125 in Ovarian Cancer: Functional Implications and Therapeutic Targeting”; Venkatesh Krishnan, PhD; Oliver Dorigo, MD, PhD; Carolyn Bertozzi, PhD
• “B7-H3 Targeted Microbubble Imaging for Early Breast Cancer Detection in the Radiographically Dense Breast”; Jeremy Dahl, PhD; Ramasamy Paulmurugan, PhD; Amalie Lutz, MD

SCI Nodal Grant Award

• “Systems Biology Approach to Dissecting Gamma-Delta T/NK Cell Cytotoxic Antitumor Networks”; Andrew Gentles, PhD; John Sunwoo, MD; Yueh-Hsiu Chien, PhD

SCI Cancer Innovation Award

• “Phase II Study of Ruxolitinib in Primary Eosinophilic Disorders and Idiopathic Hypereosinophilic Syndrome” Gotlib, Shomali
• “Identification of causal cardiac-specific antigens in immune checkpoint inhibitor-induced fulminant myocarditis” S. Wu, Nguyen, Davis
• “ Evaluating the Efficacy of Autologous iPSC-Based Vaccine in Treating Breast Cancer ” J. Wu, Pegram, Telli
• “Promoting Physical Activity among African American Breast Cancer Survivors” Goldman Rosas, McClinton-Brown
• "Lifestyle-related determinants of chronic inflammation in girls at increased breast cancer risk: A pilot study" John, Maecker
• "Automated Pathologic Image Analysis for the Prediction of Microsatellite Instability (MSI) in Colorectal Cancer" Rubin, Shen
• "Pilot study to improve survivorship care related to fertility and family-building after cancer" Benedict