The Cancer Immunotherapy Program brings together basic scientists, translational investigators and clinician scientists to discover fundamental principles that regulate immune responses to cancer and to translate this understanding into novel cancer therapies. A major focus is on comprehensive immune profiling, using tools for high dimensional analysis of immune responses. Fundamental modeling of cancer therapeutics is conducted in murine models and the Program has an increasing effort in translating novel therapeutics to the clinic and utilizing patient samples to study the tumor: immune interface.