Journal Club 2019-2020

Both MCTI and CSI students are required to attend the IMMUNOL 305 Immunology Journal Club for their First through Third years. Attendance is optional for Fourth year and above graduate students.

Announcement for Journal Club 2019-2020: Journal Club will now be open to faculty. Please refer to the schedule below. Faculty are encouraged to attend. The paper of the week will continue to be presented by a student, but we ask that the presenting student’s advisor make every effort to attend the journal club to facilitate discussion.  If your student is presenting, they will contact you about scheduling. Papers will be posted on this page each week.

Fall Quarter: Tuesdays at 3:00-4:00 pm, LKSC Room 308
Winter Quarter: Tuesdays at 10:30-11:30am, LKSC Room 209
Spring Quarter: Tuesdays at 3:00-4:00, Online/Video Conference

Mar March 31 Tue 2020

Kalani Rastnasiri, Rotating Lab
Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.

Wang X, Ni L, Wan S, Zhao X, Ding X, Dejean A, Dong C. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Immunity. 2020 Feb 18;52(2):328-341.e5. doi: 10.1016/j.immuni.2020.01.006. Epub 2020 Feb 11. PubMed PMID: 32049050.

Download article here


Apr April 03 Fri 2020

Julia Adamska, Pulendran Lab
Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. 

Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R. Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Nat Immunol. 2019 Dec;20(12):1681-1691. doi: 10.1038/s41590-019-0513-z. Epub 2019 Oct 21. PubMed PMID: 31636462.

Download article here


Apr April 07 Tue 2020

Grayson Rodriguez, Rotating Lab
Human chimeric antigen receptor macrophages for cancer immunotherapy.

Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, Zeeman M, et al. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol. 2020 Mar 23; 1–7.

Download article here


Apr April 14 Tue 2020

Valentino Sudaryo, Rotating Lab
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. 

Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N. Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. Nat Immunol. 2020 Feb;21(2):158-167. doi: 10.1038/s41590-019-0569-9. Epub 2020 Jan 13. PubMed PMID: 31932809; PubMed Central PMCID: PMC6983345.

Download article here


Apr April 21 Tue 2020

Aaron Trotman-Grant, Rotating Lab
Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.

Tan Y, Kagan JC. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019 Apr 4;177(2):384-398.e11. doi: 10.1016/j.cell.2019.01.039. Epub 2019 Mar 7. PubMed PMID: 30853218; PubMed Central PMCID: PMC6710629.

Download article here


Apr April 28 Tue 2020

Katherine Nico, Howitt Lab
Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses.

Nadafi R, Gago de Graça C, Keuning ED, Koning JJ, de Kivit S, Konijn T, et al. Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses. Cell Rep. 2020 Mar 24;30(12):4110-4123.e4. doi:
10.1016/j.celrep.2020.03.007. PubMed PMID: 32209472.

Download article here


May May 05 Tue 2020

Camilo Espinosa, Rotating Lab
A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes.

Emming S, Bianchi N, Polletti S, Balestrieri C, Leoni C, Montagner S, et al. A molecular network regulating  the proinflammatory phenotype of human memory T lymphocytes. Nat Immunol. 2020 Apr;21(4):388-399. doi: 10.1038/s41590-020-0622-8. Epub 2020 Mar 16. PubMed PMID: 32205878; PubMed Central PMCID: PMC7100912.

Download article here


May May 12 Tue 2020

Maddie Lee, Rotating Lab
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner.

Farsakoglu Y, Palomino-Segura M, Latino I, Zanaga S, Chatziandreou N, Pizzagalli DU, et al. Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner. Cell Rep. 2019 Feb 26;26(9):2307-2315.e5. doi: 10.1016/j.celrep.2019.01.104. PubMed PMID: 30811982.

Download article here


May May 19 Tue 2020

Rachel Ee, Rotating Lab
PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer. 

Diskin B, Adam S, Cassini MF, Sanchez G, Liria M, Aykut B, et al. PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer. Nat Immunol. 2020 Apr;21(4):442-454. doi: 10.1038/s41590-020-0620-x. Epub 2020 Mar 9. PubMed PMID: 32152508.

Download article here


May May 26 Tue 2020

Joe Gonzalez, Wang Lab
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus. 

Goel RR, Wang X, O'Neil LJ, Nakabo S, Hasneen K, Gupta S, et al. Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5409-5419. doi: 10.1073/pnas.1916897117. Epub 2020 Feb 24. PMID: 32094169; PMCID: PMC7071891.

Download article here


Jun June 02 Tue 2020

Jack Silberstein, Cochran Lab
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. 

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. PMID: 32142651; PMCID: PMC7102627.

Download article here