Faculty Grants and Awards

Title: Stabilized liposome hydrogels for localized growth factor delivery to the infarcted myocardium - Sarah Heilshorn, PhD (PI), Joseph Woo, MD (Co-I)

Elucidating the Role of Inflammation in Transthyretin Cardiac Amyloidosis - Kevin Alexander, MD (PI), Joseph Woo, MD (Co-PI)

The American Heart Association’s 2021 Clinical Research Prize to be awarded to Joseph Woo, M.D., of Stanford University

The Clinical Research Prize is awarded annually to recognize an individual making outstanding contributions to the advancement of clinical science relevant to the Association’s mission. Dr. Woo’s expertise as a surgeon includes thoracic aortic surgery, mitral and aortic valve repair, mechanical circulatory support and thoracic transplant. He has pioneered novel operations and minimally invasive approaches for valve repair and reconstruction.

"Human Bone Marrow Derived Bilayer Smooth Muscle -Endothelial Progenitor Cell sheets Augment Post-infarction Ventricular Function: Implication for Multi-lineage Cellular Tissue Engineering Clinical Translation"

PI: Yasuhiro Shudo, MD, Collaborator: Y. Joseph Woo, MD

Funding Years: 2021 – 2026

A pilot study for an engineered HGF fragment for the treatment of myocardial infarction in a preclincal ovine model

Y. Joseph Woo, MD, Amanda Steele (PhD candidate)

Funding Years: 2008 – 2024

Heart attack and its complications comprise a global health problem for which there are few highly effective treatments. As an innovative therapy, this proposal seeks to amplify the body's native repair machinery by stimulating vascular progenitor cells in the bone marrow and then specifically directing them to the heart to grow new perfusing blood vessels to the damaged heart muscle and providing a clinically viable treatment for human disease.

Toward the development of novel therapeutic strategies to replicate the benefits of exercise

Patricia Nguyen, MD (PI), Ngan Huang, PhD (Co-I), Jonathan Myers, PhD (Co-I)

The  International Society for Applied Cardiovascular Biology (ISACB) is dedicated to enhancing discovery, development and clinical translation of cutting edge biomedical science for innovative, state of the art cardiovascular diagnostic and therapeutic modalities. The 2024 Elena Aikawa Trailblazer Award is named after Dr. Elena Aikawa in recognition of her scientific accomplishments and dedication to mentoring female and underrepresented scientists.

T33IP6580 (Huang) 7/1/23-6/30/25
Tobacco Related Disease Research Program
Role of Nicotine on Endothelial-to-Mesenchymal Transition in Atherosclerotic Lesions
The effect of nicotine in regulating EndoMT in the progression of atherosclerosis is largely unknown. Accordingly, Specific Aim 1 is to test the hypothesis that nicotine induces EndoMT using an in vitro ‘atherosclerosis-on-a-chip’ platform. In a complementary strategy, Specific Aim 2 will test the hypothesis that nicotine induces EndoMT using an endothelial reporter atherosclerosis mouse model.

R41HL170875 STTR Phase I (Lee/Huang) 9/01/2023-8/31/2024              
NIH / NHLBI                                                                                       
Novel Highly Regenerative and Scalable Progenitor Cell Exosomes for Treating Peripheral Artery Disease 
The objective is to test the efficacy of exosomes derived from pluripotent stem cells for treatment of peripheral arterial disease in a mouse model.

R21 HL172096-01  (McCloskey/Huang) 12/15/23-11/30/25         
NIH / NHLBI                                                                                       
Biomaterials for delivery and maintenance of tip endothelial cells
We will compare the ability of pluripotent stem cell-derived tip endothelial cells (ECs) versus non-tip ECs to rescue the muscle in a hindlimb ischemic mouse model. For delivery, we employ spatially nanopatterned collagen biomaterial scaffolds to enhance cell survival after transplantation into the ischemic limb. Lastly, we will incorporate placental growth factor (PIGF) mRNA delivery from aligned nanopatterned collagen biomaterials to support the release of PlGF protein for maintaining the angiogenic phenotype of tip ECs, and/or directing in vivo the differentiation of stalk to tip ECs.

PR230446 PRMRP Discovery Award (Huang, PI) 1/1/24-12/31/25         
Department of Defense                                                                     
Application of electrical current for promoting lymphatic regeneration                      
The objective is to employ electrical currents and collagen scaffolds for stimulating lymphatic regeneration in a rat model of lymphedema.

The Alan T. Hirsch, MD, Mid-Career Award in Vascular Medicine encourages and supports the efforts of peripheral vascular disease investigators who are at mid-career level. This award was given to Ngan Huang, PhD, at the Vascular Discovery: From Genes to Medicine 2023 Scientific Sessions, May 10-13, 2023.

The Society for Biomaterials Award recognizes an individual SFB member who has demonstrated outstanding achievements in and / or contributions to the field of biomaterials research. 

Funding years: 2023 to 2028

The Research Career Scientist Award is given to established, independent investigators who have distinguished themselves through scientific achievements and contributions to the VA research program and contribute to the VA in other service-focused roles and opportunities. Huang’s strong record of scientific contributions, funding history, and distinction within the VA and research community was recognized for this award.

The Stanford Cardiovascular Institute awarded the 2022 CVI Recognition Award to Ngan F. Huang, PhD, for her efforts in leading and providing educational opportunities for CVI members and active participation in numerous activities to strengthen the CVI community.

Project Title: Engineered Extracellular Matrix Cues Affecting Endothelial Phenotypic Change
Project Period: January 1, 2023 - December 31, 2025

Abstract: Blood vessel cells known as endothelial cells can change to another type of cell and contribute to vascular disease. This change is associated with plaque formation within atherosclerotic vessels. A key component of blood vessels is the underlying scaffolding structure that provides physical support and instructs endothelial cells. It isn't known if the small-scale molecular structure of the blood vessel affects the changes in cell type. This Boosting Research Ideas for Transformative and Equitable Advances in Engineering (BRITE) Pivot award supports research to discover new knowledge of how the mechanical properties of the scaffolding structure influence endothelial fate. The findings from this award may influence the design of new therapies to treat vascular diseases. Therefore, the findings from this award will benefit our society by advancing national health. The educational activities promote the development of military veteran college students from underserved communities through lectures, laboratory training, and summer research experiences that broaden participation in scientific research.

The Stanford Cardiovascular Institute has awarded Ngan F. Huang, PhD, the 2022 Seed Grant Award for the project, “Engineering protease-guided drug delivery to implanted stem cells for treatment of peripheral arterial disease.” Dr. Huang will serve as the principal investigator on the project, along with co-principal investigator Xiaojing Gao, PhD, Assistant Professor of Chemical Engineering.

This proposal aims to improve the clinical efficacy of iPSC-EC transplants through the design of a novel combinatorial family of engineered extracellular matrices (eECMs) with independently tunable biochemical and biomechanical cues to allow identification of optimal eECMs that promote iPSC-EC angiogenic potential. An in vitro array of 279 unique, combinatorial eECMs will be screened for enhancement of iPSC-EC viability, phenotype, and function, and optimal eECMs will be validated in a preclinical animal model of PAD. (April 2019)

This study examines the role of spatially patterned nano-scale biomaterials in enhancing the potential of stem cell-derived endothelial cells to survive and restore blood flow in the setting of peripheral arterial disease. The results of the proposed small and large animal studies will improve the efficacy stem cell therapy for treating peripheral arterial disease. (February 2018)

The goal of this project is to develop a tissue chip for high-throughput systematic control of ECM chemical composition, substrate stiffness, and mechanical stretch to identify microenvironmental conditions that optimize muscle progenitor cell survival, myotube formation, and contractility. (July 2019)

We propose to engineer a murine skeletal muscle tissue containing both muscle and vascular cells for treatment of acute volumetric muscle loss in a murine model. (April 2019)

The goal of this study is to test the efficacy of engineered skeletal muscle in microgravity to resemble salient characteristics of muscle with sarcopenia, and to apply this platform for testing drugs for treatment of sarcopenia. (October 2018)

The goal of this project is to engineer a microchip platform for testing the quality of human multipotent stromal cell growth and differentiation under varying substrate stiffness and extracellular matrix proteins. (September 2018)

Induced Pluripotent Stem Cell-Derived Aligned Vascular Graft with Improved Patency

Ngan Huang, PhD

Dr. William Hiesinger was awarded the 2022 Stanford Human-Centered Artificial Intelligence (HAI) Seed Research Grant to support a project on developing SuTr, a foundational vision model for artificial intelligence in surgery.

Project title: SuTr: A Foundational Model for AI in Surgery

Project description: The operating room is a highly demanding environment in which surgeons must process vast amounts of information to make timely and informed decisions that can greatly impact surgical outcomes. However, prolonged working hours coupled with the well-established effects of fatigue on cognitive and technical performance can lead to a significant potential for error, with detrimental consequences to patient health. To mitigate these human failings, we focus on developing SuTr, a foundational vision model for surgery with the ability to provide real-time intraoperative guidance and analysis. By leveraging the latest advancements in artificial intelligence and machine learning, SuTr aims to gain a holistic understanding of the operative scene to provide actionable insights into enhancing surgical precision and techniques, with the goal of decreasing error rates and complications, and paving the way towards autonomous robotic surgery.

Project period: 1/1/2022 - 12/31/2026

This project aims to develop and validate a core echocardiography artificial intelligence platform designed to extract the full density of information in a standard echocardiogram. Echocardiography is a ubiquitous imaging modality, and such a system has an immediate impact on how we manage heart failure – a disease that affects an estimated 6.5 million people in the United States alone. Using their designed ECHO AI platform, the research team proposes to build tools for surgical decision support and survival forecasting in patients with heart failure and early screening tools to identify individuals at high risk of developing heart failure in the future.

Integration of Novel Cardiac Monitoring Devices with Artificial Intelligence for Improved and Scalable Heart Failure Manage  

Funding period: 11/1/2021 - 10/31/2022

The Stanford Institute for Human-Centered AI  strives to foster a culture of interdisciplinary AI research in which technological advancements are inextricably linked to research about their potential societal impacts. HAI builds on the strength of Stanford research by offering multiple grant programs.

The AIMI Seed Grant program seeks to stimulate and support the creation of innovative and high-impact ideas that will advance the fields of medicine & imaging. AIMI funds exciting and innovative projects based on their scientific merit, potential clinical impact, and alignment with program priorities.

Project title: "Automating the Analysis of Echocardiographic Images for Predicting Post-Operative Right Heart Failure"

PI: William Hiesinger, Jeffrey Teuteberg
Co-Investigators: Rohan Shad, Nick Quach, Patpilai Kasinpila

Predicting post-operative right ventricular failure (RVF) has proven challenging despite decades of research. We aim to use a neural network to segment transthoracic echocardiograms (TTEs) collected as part of standard clinical care. The segmented TTEs will be used for the extraction of novel RVF metrics that have shown promise in predicting post-operative RVF, which will then be used to generate predictive models that are both sensitive and specific for post-operative RVF. The outcome of this research project will be the creation of a validated, clinically translatable, end-to-end automated tool for predicting postoperative RVF in patients undergoing LVAD implant.

The sarcoplasmic reticulum (SR) is a membrane-bound structure found within the cardiac muscle cells. Its main function is to regulate the flow of calcium, releasing calcium ions to the surrounding muscle fibers during contraction of the heart muscle and absorbing calcium during relaxation; calcium makes the heart pump. A crucial protein that regulates the function of the SR is phospholamban (PLN); mutations in the PLN gene result in defective PLN which can in turn causes a genetic, or inherited, form of heart failure. The CURE-PLaN network will focus on one particular mutation that is found in patients in the United States and Europe. Their objective is to understand how patients with the mutation develop heart failure, and why not all patients with the mutation have the same clinical course.  Network scientists will use mouse models, and single muscle cell lines to learn more about the genetics of the disease and how to alter the SR and PLN to make heart muscle cells work more efficiently. This Leducq network will work with the PLN Patient Foundation to focus on combatting PLN induced heart failure. Their ultimate goal is to cure PLN induced heart failure in humans.

CRISPR-mediated Therapy for Cardiac Laminopathies

Co-PI: Ioannis Karakikes, MD, Co-PI: Kevin Wang, MD, PhD

Dilated cardiomyopathy (DCM) is a leading cause of heart failure. The emergence of induced pluripotent stem cell (iPSC) technology offers an experimental human-based model to predict individual disease manifestations and design targeted therapies. This project advances the concept that patient stem cell derived heart cells can serve as a new paradigm to fill the knowledge gaps in our understanding of how certain gene mutations lead to the DCM phenotype, and ultimately promote the implementation of precision medicine. (June 2018)

The goal of this study is to leverage recent discoveries in human genetics and technological breakthroughs in genome engineering to develop novel therapies for cardiovascular disease. This study will explore the feasibility of using new modalities, such as CRISPR-mediated base-editing, to introduce naturally occurring mutations in the genome that could lower triglyceride levels, potentially conferring cardioprotection. (July 2019)

MicroRNAs (miRNAs) are newly discovered regulators of gene expression in the heart. Karakikes's team will investigate the role of miR-152 in the pathogenesis and progression of diabetic cardiomyopathy. This knowledge should ultimately be of value for understanding the etiology of the disease and they will define potential therapeutic targets for the future treatments. (December 2017)

The Role of Telomere Dysfunction in The Pathogenesis of Familial Dilated Cardiomyopathy 

Ioannis Karakikes, MD

Dr. Yihan Lin receives funding to study maternal and fetal outcomes in Rwandan women with mechanical heart valves

Yihan Lin, MD, MPH, a clinical assistant professor in the Department of Cardiothoracic Surgery at Stanford School of Medicine, has been awarded a Clinician Educator Award from the Stanford Maternal and Child Health Research Institute to support her project on maternal and fetal health outcomes in low-income countries.

January 25, 2024

Organ Care System (OCS)

Michael Ma, MD (PI), Perry Choi, MD (Co-I), Yellappa Palagani, PhD (Co-I)

Robert L. Replogle, MD, was a talented pediatric cardiac surgeon as well as an educator, researcher, and national leader in cardiothoracic surgery. The purpose of the Replogle Fellowship is to facilitate the continuing education of a deserving young faculty surgeon or resident committed to the treatment of congenital heart disease in neonates, infants, children, and adults.

"Development of Optogenetic Thrombin for Light-directed Hemostasis During Unifocalization Surgery"

PI: Mark Skylar-Scott, PhD, Co-PI: Michael Ma, MD, Collaborator: Doff McElhinney, MD

Award Year: July 2020 – July 2021

The Stanford Maternal and Child Health Research Institute (MCHRI) Pilot Grants funds innovative maternal and child health-focused clinical and translational research.

• NIH KL2 Mentored Career Development Program
  

Funding Years: Awarded Fall 2019, and runs through Fall 2021

Project Title: "Optimization of Surgical Repair Strategies in an Ex Vivo Model of Single Ventricle Physiology."

Project Abstract: Single ventricle defects are rare congenital disorders that affect one of the two ventricles of the heart, leading to one of them being undersized, underdeveloped, or missing a valve. These defects are fatal without surgical intervention, and surgeries typically need to be performed soon after birth. Staged surgical repair is performed shortly after birth and involves the rerouting of blood flow into the stages of Single Ventricle Physiology (SVP), from Norwood, to Glenn, and ultimately, Fontan circulation. Although there are variations of this transition, it generally involves rerouting the inferior and superior vena cavae directly into the pulmonary arteries, and subsequently utilizing a single ventricle and atrioventricular (AV) valve to support systemic circulation. Atrioventricular (AV) valve function is an important component of this circulation, especially as the longevity of children palliated with SVP continues to rise. While many risk factors associated with SVP have been overcome, numerous clinical studies have shown increased morbidity and mortality associated with AV valve insufficiency. The purpose of this proposal is to study heart valve function in response to Single Ventricle Physiology (SVP), with the goal of learning how SVP affects valve biomechanics, fluid dynamics, and tissue changes at the molecular level.

"Development of Optogenetic Thrombin for Light-directed Hemostasis During Unifocalization Surgery"

PI: Mark Skylar-Scott, PhD, Co-PI: Michael Ma, MD, Collaborator: Doff McElhinney, MD

Research Funded by the CHRI, Psychosocial, Cognitive, and Quality of Life Outcomes in Children and Adults with Repaired Tetralogy of Fallot with Pulmonary Atresia and Major Aortopulmonary Collateral Arteries

Presented annually at the World Conference on Lung Cancer (WCLC), the Robert J. Ginsberg Lectureship Award recognizes leaders who have made significant contributions to the lung cancer community. This honor was presented to Dr. Backhus during the plenary session of the 2024 WCLC held in San Diego, California, from September 7-10, 2024.

The Hedwig van Ameringen Executive Leadership in Academic Medicine® (ELAM) Program for Women at Drexel University College of Medicine has selected Leah Backhus, MD, to its 2022-2023 Executive Leadership in Health Care (ELH), a program is designed for senior-level women leaders interested in advancing in hospitals and healthcare systems to positions such as CEO, CMO, CNO and CFO. 

Awarded for: "iSALT: Imaging Surveillance After Lung Cancer Treatment" - VA HSR&D IIR Merit Award (HX002456-01A2)

Principal Investigator: Dr. Leah Backhus

The VA Health Services Research & Development Investigator-Initiated Research program enables VA clinicians and social scientists to pursue their personal research interests while advancing HSR&D priorities and contributing to the quality, effectiveness, and efficiency of VA health care. The IIR program spans the traditional, enduring areas of health services research (cost, quality, and access) as well as emerging areas and current topics (e.g., patient safety). Most projects are multidisciplinary in nature, involving a team of researchers with expertise in a variety of clinical specialties and academic disciplines. Many IIR studies involve data collection at multiple sites, to enhance generalizability and eventual dissemination. Rigorous scientific and programmatic review ensures the high quality of IIR research, and funding is highly competitive. All proposals undergo peer review by an interdisciplinary group of VA- and non-VA researchers. Recommendations of the Scientific Review and Evaluation Board regarding a project's scientific/technical merit, as well as importance to VA, inform all IIR funding decisions.

The Dr. Dwight C. McGoon Award is an award given annually by the TSRA to an outstanding young faculty member in cardiothoracic surgery in recognition of his or her commitment to resident education and mentorship. Each year, cardiothoracic surgery residents in North America are eligible to nominate a faculty member within the first ten years of their attendingship who has demonstrated a remarkable interest in resident training — inside or outside of the operating room. From the nominated faculty, the winner will be selected and presented with the award at the STS Annual Meeting.

Dr. Leah Backhus is the first woman to receive the award in fourteen years, the first African American recipient, and the first recipient from Stanford.

Awarded to the Stanford Thoracic Surgery Clinical Research Program
PI: Joseph Shrager
Co-PI: Leah Backhus

Funding Year: 2019 – 2023

The Stanford Thoracic Surgery Clinical Research Program was awarded an NIH R01 titled: "A mechanistic clinical trial of JAK inhibition to prevent ventilator-induced diaphragm dysfunction." Ventilator-induced diaphragm dysfunction is a process in which the diaphragm (the major respiratory muscle) weakens and atrophies while a patient is on mechanical ventilation (MV). This can lead to prolonged need for the ventilator, resulting in increased complications (e.g., ventilator-associated pneumonia) and deaths. The long-term goal of this program has been to develop/identify a drug that could be used to prevent this process and thus reduce ICU morbidity/mortality. The program worked out the molecular mechanisms underlying the process in human tissue from mechanically ventilated patients and in animal MV experiments. One molecular pathway we identified as being important is the JAK/Stat pathway. In this NIH-funded clinical trial, they are randomizing patients to a JAK inhibitor (Tofacitinib) vs placebo and then taking diaphragm biopsies early and late (about 6 hours apart) during esophagectomies. They are then studying the biopsies to assess for whether they have successfully blocked the involved pathways and for whether they have prevented the onset of diaphragm weakness (using a single-fiber muscle force transduction device).

Funding Year: 2019

The Levi Watkins Innovation and Leadership Development Scholarship provides up to $5,000 for cardiothoracic surgeons who are within 10 years of their first faculty appointment and supports travel to a center of excellence for the purposes of acquiring clinical, translational, or leadership training.

TSF awarded the Watkins scholarship to Dr. Backhus in 2019. In November, she traveled to the Mayo Clinic in Phoenix, Arizona, where she studied pectus repair with Dawn Jaroszewski, MD, MBA, a national leader in surgery for pectus carinatum, excavatum, and mixed defects in adults.

Dr. Leah Backhus, co-director of the Stanford Thoracic Surgery Clinical Research Program, on winning the award: "My goal in pursuing this scholarship was to gain experience in a variety of repair techniques by visiting a high-volume center performing minimally invasive adult pectus surgery and complex reconstructions,” she said. “As the final goal is to establish a program at my home institution, it was important to also gain experience with patient selection and program infrastructure."

Carolyn E. Reed, MD, was a thoracic surgeon, an educator and successful researcher, who died early while still in her prime. She served as the first female Chair of the ABTS and was also President of the STSA and STS. The Carolyn E. Reed Traveling Fellowship Award in her name provides support of up to $10,000 for a clinically-established woman cardiothoracic surgeon, or woman resident in her last year of cardiothoracic surgery residency, to travel to another institution for the purpose of learning a new skill or technology.

Project: "Tracheobronchoplasty for Tracheobronchomalacia"

The Dr. Dwight C. McGoon Award is an award given annually by the TSRA to an outstanding young faculty member in cardiothoracic surgery in recognition of his or her commitment to resident education and mentorship. Each year, cardiothoracic surgery residents in North America are eligible to nominate a faculty member within the first ten years of their attendingship who has demonstrated a remarkable interest in resident training — inside or outside of the operating room. From the nominated faculty, the winner will be selected and presented with the award at the STS Annual Meeting.

Dr. Natalie Lui is the second woman to receive the award in fourteen years, and Stanford is one of only two institutions to receive this award twice.

• Western Thoracic Surgical Association Donald B. Doty Educational Award 2019
  

"3D printing for cardiothoracic surgical education: a mediastinoscopy model"

• Stanford Clinical Innovation Fund 2019

"Identifying barriers to lung cancer screening enrollment"

• The Thoracic Surgery Foundation Carolyn E. Reed Traveling Fellowship Award 2018

"Advanced endoscopic techniques for esophageal disease at the Oregon Clinic"