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Advancing the understanding of the molecular and cellular mechanisms of aortic aneurysm formation, with particular interest in patients with Marfan Syndrome

Investigative studies include:

1.

Genomic and transcriptomic analyses of pathogenesis of aortic aneurysms arising due to Marfan Syndrome




 

2.

Development of in vitro disease models of Marfan Syndrome using primary culture cells and inducible pluripotent stem cell (iPSC) technologies


 

3.

Use of an in vivo murine model of Marfan Syndrome to study aortic aneurysm formation via biological assays including gene expression quantification, protein modification analyses, and immunohistochemistry.