Clinical Trials Unit
Stanford University School of Medicine's Center for Advanced Dermatologic Investigation is the Dermatology Department's clinical trials unit.
The Center is home to 12-15 ongoing clinical studies, investigating the safety and efficacy of new and currently available drugs and over-the-counter medications. The Center works with Stanford's own panel on medical research, leading pharmaceutical companies,and the Food and Drug Administration to safely and ethically expand the medical field's knowledge of dermatologic treatments. New studies begin regularly, and the Center continues to recruit patients with skin aging, sun damage, skin cancer (including basal cell carcinomas), psoriasis, atopic dermatitis, rosacea, and other dermatologic diseases for ongoing studies.
Skin Aging Studies
We seek to understand the human aging processes as it relates to skin on a fundamental level. To this end, our studies focus on clinical and translational research efforts ranging from: (1) the analysis of gene changes which predispose individuals to exceptionally youthful skin to (2) molecular signatures that may be biomarkers for aging skin to (3) the careful study of new candidate agents which might affect the skin aging process.
Nonmelanoma Skin Cancer
Recent advances in our understanding of basal cell skin cancer biology have enabled the development of cutting edge study drugs which combat tumor growth. We are currently home to a number of clinical trials at the forefront of potential therapy for advanced or metastatic basal cell cancer. In addition, we seek to understand the biology of basal cell skin cancers and to identify molecular predictors for treatment success.
Acne Rosecea
This is a common and frustrating chronic inflammatory condition of the face, usually affecting older individuals. The causes of this complex condition are the subject of much study. Our clinical studies seek to identify new topical or oral medications to improve the symptoms of acne rosacea.
Contact
For more information, please email dermtrials@stanford.edu
Featured Clinical Trials
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: Perhexiline
- drug: Perhexiline
- device: Use of bioanalytical assay to monitor plasma levels of perhexiline
Eligibility
Key Inclusion Criteria:
- Hypertrophic cardiomyopathy with symptoms of moderate-to-severe heart failure
- Left ventricular hypertrophy with maximum LV wall thickness ≥ 15 mm
- Left ventricular ejection fraction ≥ 50%
- Able to perform exercise testing but unable to exceed 75% of the predicted
age-adjusted maximum level
Key Exclusion Criteria:
- CYP2D6 Poor Metabolizer (PM) status
- History of a known chronic liver disease
- ALT, AST, alkaline phosphatase, or LDH > 1.5 x upper limit of normal
- Total Bilirubin > 2.0 x upper limit of normal
- Severe LV outflow obstruction
- Asymptomatic patients or cardiomyopathy-related criteria as per protocol
- QT interval related criteria as per protocol
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Austin Bland
6507256911
I'm interested
Psoriasis Clinical Trials
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: Perhexiline
- drug: Perhexiline
- device: Use of bioanalytical assay to monitor plasma levels of perhexiline
Eligibility
Key Inclusion Criteria:
- Hypertrophic cardiomyopathy with symptoms of moderate-to-severe heart failure
- Left ventricular hypertrophy with maximum LV wall thickness ≥ 15 mm
- Left ventricular ejection fraction ≥ 50%
- Able to perform exercise testing but unable to exceed 75% of the predicted
age-adjusted maximum level
Key Exclusion Criteria:
- CYP2D6 Poor Metabolizer (PM) status
- History of a known chronic liver disease
- ALT, AST, alkaline phosphatase, or LDH > 1.5 x upper limit of normal
- Total Bilirubin > 2.0 x upper limit of normal
- Severe LV outflow obstruction
- Asymptomatic patients or cardiomyopathy-related criteria as per protocol
- QT interval related criteria as per protocol
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Austin Bland
6507256911
I'm interested
Dermatology Clinical Trials
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: Perhexiline
- drug: Perhexiline
- device: Use of bioanalytical assay to monitor plasma levels of perhexiline
Eligibility
Key Inclusion Criteria:
- Hypertrophic cardiomyopathy with symptoms of moderate-to-severe heart failure
- Left ventricular hypertrophy with maximum LV wall thickness ≥ 15 mm
- Left ventricular ejection fraction ≥ 50%
- Able to perform exercise testing but unable to exceed 75% of the predicted
age-adjusted maximum level
Key Exclusion Criteria:
- CYP2D6 Poor Metabolizer (PM) status
- History of a known chronic liver disease
- ALT, AST, alkaline phosphatase, or LDH > 1.5 x upper limit of normal
- Total Bilirubin > 2.0 x upper limit of normal
- Severe LV outflow obstruction
- Asymptomatic patients or cardiomyopathy-related criteria as per protocol
- QT interval related criteria as per protocol
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Austin Bland
6507256911
I'm interested
Pediatric Dermatology Clinical Trials
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: Perhexiline
- drug: Perhexiline
- device: Use of bioanalytical assay to monitor plasma levels of perhexiline
Eligibility
Key Inclusion Criteria:
- Hypertrophic cardiomyopathy with symptoms of moderate-to-severe heart failure
- Left ventricular hypertrophy with maximum LV wall thickness ≥ 15 mm
- Left ventricular ejection fraction ≥ 50%
- Able to perform exercise testing but unable to exceed 75% of the predicted
age-adjusted maximum level
Key Exclusion Criteria:
- CYP2D6 Poor Metabolizer (PM) status
- History of a known chronic liver disease
- ALT, AST, alkaline phosphatase, or LDH > 1.5 x upper limit of normal
- Total Bilirubin > 2.0 x upper limit of normal
- Severe LV outflow obstruction
- Asymptomatic patients or cardiomyopathy-related criteria as per protocol
- QT interval related criteria as per protocol
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Austin Bland
6507256911
I'm interested
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: Perhexiline
- drug: Perhexiline
- device: Use of bioanalytical assay to monitor plasma levels of perhexiline
Eligibility
Key Inclusion Criteria:
- Hypertrophic cardiomyopathy with symptoms of moderate-to-severe heart failure
- Left ventricular hypertrophy with maximum LV wall thickness ≥ 15 mm
- Left ventricular ejection fraction ≥ 50%
- Able to perform exercise testing but unable to exceed 75% of the predicted
age-adjusted maximum level
Key Exclusion Criteria:
- CYP2D6 Poor Metabolizer (PM) status
- History of a known chronic liver disease
- ALT, AST, alkaline phosphatase, or LDH > 1.5 x upper limit of normal
- Total Bilirubin > 2.0 x upper limit of normal
- Severe LV outflow obstruction
- Asymptomatic patients or cardiomyopathy-related criteria as per protocol
- QT interval related criteria as per protocol
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Austin Bland
6507256911
I'm interested
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: Perhexiline
- drug: Perhexiline
- device: Use of bioanalytical assay to monitor plasma levels of perhexiline
Eligibility
Key Inclusion Criteria:
- Hypertrophic cardiomyopathy with symptoms of moderate-to-severe heart failure
- Left ventricular hypertrophy with maximum LV wall thickness ≥ 15 mm
- Left ventricular ejection fraction ≥ 50%
- Able to perform exercise testing but unable to exceed 75% of the predicted
age-adjusted maximum level
Key Exclusion Criteria:
- CYP2D6 Poor Metabolizer (PM) status
- History of a known chronic liver disease
- ALT, AST, alkaline phosphatase, or LDH > 1.5 x upper limit of normal
- Total Bilirubin > 2.0 x upper limit of normal
- Severe LV outflow obstruction
- Asymptomatic patients or cardiomyopathy-related criteria as per protocol
- QT interval related criteria as per protocol
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Austin Bland
6507256911
I'm interested