Derek Boothroyd, Ph.D.
Senior Biostatistician

Dr. Boothroyd joined the QSU in October 2014. He received his PhD in Statistics from Stanford University in 2001 where his doctoral research was applied to modeling progression of kidney function in diabetic nephropathy. While a student at Stanford, he worked on studies in the Department of Health Research and Policy relating to coronary artery disease, primarily a clinical trial comparing cost-effectiveness and quality of life after coronary revascularization. After graduating, he joined that department as a staff statistician, working there from 2001 until joining QSU.  He continued to collaborate primarily on studies relating to coronary revascularization including analyses of clinical trials, of pooled individual patient data from multiple clinical trials, and of data from Medicare.  Between 2003 and 2010 he also worked with researchers at the Center for Quality Management in Public Health (now the Population Health group) at the Palo Alto VA looking at national VA patterns of care and outcomes for patients with HIV and Hepatitis C.  His statistical interests include treatment heterogeneity, matching for observational studies, and cost-effectiveness.

Methodology Area of Interest:  Investigation of heterogeneity of treatment effects, matching for observational or randomized studies, survival analysis, cost effectiveness. 

Clinical Area of Interest: Primary medical areas of research experience include cardiology (particularly studies of coronary artery disease), infectious diseases (largely HIV and hepatitis C), and nephrology (mainly diabetic nephropathy).

Selected Publications: 

Schroeder JS, Gao SZ, Alderman EL, Hunt SA, Johnstone I, Boothroyd DB, Wiederhold V, Stinson EB. A preliminary study of diltiazem in the prevention of coronary artery disease in heart-transplant recipients.  New England Journal of Medicine 1993; 328: 164-170.

Hlatky MA, Rogers WJ, Johnstone I, Boothroyd D, Brooks MM, Pitt B, Reeder G, Ryan T, Smith H, Whitlow P, Wiens R, Mark D, for the BARI Investigators.  Medical care costs and quality of life after randomization to coronary angioplasty or coronary bypass surgery.  New England Journal of Medicine 1997; 336: 92-99.

Hlatky MA, Boothroyd DB, Vittinghoff E, Sharp P, Whooley MA, for the HERS Research Group.  Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: Results from the Heart and Estrogen/Progestin Replacement Study (HERS) Trial.  JAMA 2002; 287: 591-597.

Lemley KV, Boothroyd DB, Blouch KL, Nelson RG, Jones LI, Olshen RA, Myers KD. Modeling GFR trajectories in diabetic nephropathy.  American Journal of Physiology. Renal Physiology 2005; 289: F863-F870.

Backus LI, Phillips BR, Boothroyd DB, Mole LA, Burgess J, Rigsby MO, Chang SW. Effects of hepatitis C virus coinfection on survival in veterans with HIV treated with highly active antiretroviral therapy.  Journal of Acquired Immune Deficiency Syndromes 2005; 39: 613-619.

Hlatky MA, Quertermous T, Boothroyd DB, Priest JR, Glassford AJ, Myers RM, Fortmann SP, Iribarren C, Tabor HK, Assimes TL, Tibshirani RJ, Go AS.  Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease.  American Heart Journal 2007; 154: 1035-1042.

Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, Carrié D, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kähler J, Kelsey SF, King SB, Kosinski AS, Lopes N, McDonald KM, Rodriguez A, Serruys P, Sigwart U, Stables RH, Owens DK, Pocock SJ.  Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials.  The Lancet 2009; 373: 1190-1197.

Backus LI, Boothroyd DB, Phillips BR, Belperio P, Halloran J, Mole LA.  A sustained virologic response reduces risk of all-cause mortality in patients with hepatitis C.  Clinical Gastroenterology and Hepatology 2011; 9: 509-516.

Hlatky MA, Boothroyd DB, Baker L, Kazi DS, Solomon MD, Chang TI, Shilane D, Go AS.  Comparative effectiveness of multivessel coronary bypass surgery and multivessel percutaneous coronary intervention: a cohort study.  Annals of Internal Medicine 2013; 158: 727-734.

Chang TI, Leong TK, Boothroyd DB, Hlatky MA, Go AS.  Acute kidney injury after CABG vs PCI: An observational study using 2 cohorts.  Journal of the American College of Cardiology 2014; 64: 985-994.


List of published papers at MyBibliography: