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Low oxygen levels during brain development may cause particular cells to differentiate too soon, a Stanford-led study found.

Studying human oligodendrocytes, which provide insulation for nerve cells, has been challenging. But a new way of generating stem-cell-derived, three-dimensional brain-cell cultures is paying off.

Three types of cells in the brain’s white matter show interwoven problems during the cognitive dysfunction that follows treatment with the cancer drug methotrexate, Stanford neuroscientists have found.

In mice, a fatal brainstem tumor was cleared by injecting it with engineered T cells that recognized the cancer and targeted it for destruction. The Stanford discovery is moving to human trials.

Young, resting neural stem cells have large protein clumps often associated with neurodegeneration. As stem cells age, the aggregates inhibit their ability to make new neurons, Stanford researchers say.

Stanford researchers have found that a small set of nerve cells in the brain regulates the debilitating seizures and cognitive deficits characteristic of the most common form of epilepsy in adults. This discovery could lead to new and better treatments.

In a multicenter study led by Stanford researchers, the number of stroke patients who died or required confinement to nursing homes was nearly cut in half, the biggest improvement seen in any stroke-related trial to date.

The grant will help Stanford investigators find out if variants in many different autism-linked genes trigger the condition by affecting molecular pathways and cellular processes.

High-grade gliomas, a group of aggressive brain tumors, cease growing in mice if a signaling molecule called neuroligin-3 is absent or its activity is blocked with drugs, a Stanford team has shown.

Stanford investigators fused two stem-cell-derived neural spheroids, each containing a different type of human neuron, then watched as one set of neurons migrated and hooked up with the other set.