Pancreatic alpha cells from people with diabetes release excess amounts of glucagon, a hormone important in blood sugar control, in a new Stanford-developed mouse model of transplanted human islets.
Roeland Nusse receives Gairdner award
The Stanford developmental biologist was honored for a lifetime of work on the Wnt signaling pathway, which plays an important role in normal development and in cancer.
Fragile DNA creates evolutionary hot spot
DNA regions susceptible to breakage and loss are genetic hot spots for important evolutionary changes, according to Stanford study. The findings may lead to new understanding of human evolution.
What sea invertebrate reveals about us
A lowly sea creature may provide a way to understand our own blood-forming system, improve our immune function and find new immune-associated tools for biological discovery, Stanford researchers say.
DNA folding key to cell differentiation
In trying to decipher the “DNA origami” responsible for the generation of transplantable human skin, Stanford researchers have uncovered a master regulatory hierarchy controlling tissue differentiation.
Analysis reveals surprising DNA secrets
DNA twitches during transcription to bring distant regions in contact and enhance gene expression, according to Stanford researchers who devised a new way to label individual, nonrepetitive DNA sequences.
Shorter bones linked to arthritis risk
Humans in Europe and Asia evolved to have shorter bones and an increased risk of osteoarthritis, a trade-off that may have helped them in colder climates, Stanford researchers say.
Ribosomes unexpectedly variable, powerful
Ribosomes, which make proteins, are startlingly variable in their composition and associations. This variability confers on them the ability to regulate genes, confounding previous ideas, Stanford researchers say.
Mouse lemur as model for human disease
Stanford researchers have identified more than 20 mouse lemurs with genetic traits for conditions such as heart disease and eye problems, making the tiny primates potentially useful for understanding diseases in humans.
Pancreatic cells change fate to produce insulin
Alpha cells can convert to insulin-producing beta cells in mice when just two genes are blocked, a new Stanford study shows. A similar mechanism may occur in people with diabetes.
Nusse wins $3 million Breakthrough Prize
The developmental biologist was honored for helping to decode how Wnt signaling proteins affect embryonic development, cancer and the activity of tissue-specific adult stem cells that repair damage after injury or disease.
What microballoons could reveal about gut
A microballoon that fits inside a fruit fly intestine could help scientists understand the forces or nutrients responsible for signaling the intestine to grow or shrink in response to food.
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