Center for Cancer Nanotechnology Excellence
for Translational Diagnostics (CCNE-TD)

Pilot and Developmental Projects

Year 1

Pilot Project 1 
Near-infrared photo-switchable nanoprobes for super-sensitive photoacoustic imaging

(J. Rao Project Lead; S. ChuX. Zheng)

Pilot Project 2
Enhancing Photoacoustic Imaging with Reactive Porous Si/Iron Oxide Core/Shell Nanoparticles

(X. Zheng Project Lead)

Year 2

Pilot Project 3 
Novel Theranostic Nanoparticles for treating Glioblastoma

(H. Daldrup-Link Project Lead)

Pilot Project 4 
Upconverting Nanoparticle as Contrast agent for Image-Guided Surgery

(E. Rosenthal Project Lead; Nutt (Tarn) Teraphonghom)

Pilot Project 5 
Enhancing Nanotechnology Solutions for Radiation Therapeutic Modalities

(J.Rao Project PI; A. Wang)

Developmental Project 1 
A Novel Raman Active Theranostic Nanoparticle Which Can Detect Oxidative Stress in Tumors

(Avnesh Thakor Project Lead)

Developmental Project 2 
A Novel Theranostic ‘PolyGOLD’ Nanoparticle Customized for Intranasal Delivery and Targeting of Glioblastoma
(Tarik Massoud Project Lead; Ramasamy Paulmurugan; Meenakshi Malhotra)

Developmental Project 3 
Optimized Production and Assessment of Therapeutic Delivery using Focused Ultrasound Gated Phase-change 
(Raag Airan Project Lead;
Kim Butts Pauly; Frederick Chin)

Developmental Project 4 
Early Cancer Detection by Highly Efficient Magnetic Sifting of Hypermethylated Circulating Tumor DNA and Methylation-Specific PCR
(Shan Wang Project Lead; Megan Hitchins Project Lead 2)

Developmental Project 5 
Prospective Clinical Sample Collection Study
(Alice Fan Project Lead)

Year 3

Pilot Project 6 
Using Nano Particles for the Delivery of a Novel dCas9-GFP blocker to prevent increased CD47 Levels and Immune Evasion of Breast Cancers

(Paola A. Betancur Project Lead)

Pilot Project 7 
Incorporation of CD2 on a Nanoparticle-based Artificial Antigen Presenting Cell Platform for Type-1 Regulatory Cell Induction and Expansion

(Maria G. Roncarolo and Rosa Bacchetta Project Leads)

Developmental Project 6 
Wireless RFID‐based Spies for Cancer Cell Monitoring

(Demir Akin Project Lead)

Developmental Project 7
A Novel Cancer Theranostics plus Radiation Strategy for Curing Glioblastoma

(Daldrup-Link Project Lead)

Developmental Project 8 
Assessing Biodistribution and Drug Delivery of IL-2R Targeted Nano-vaults In Vivo

(C. Garrison Fathman Project Lead)

Developmental Project 9 
Neural Stem Cell-derived Engineered Extracellular Vesicles (eEV) Loaded with Custom MicroRNAs and Gold-coated Iron Oxide Nanoparticles (GIONs) as a Targeted Theranostic Strategy for Multimodal Imaging and Therapy of Glioblastoma

(Ramasamy Paulmurugan Project Lead)

Developmental Project 10
New Nanoassembly Strategies to Enhance and Amplify Cancer Treatment Efficacy

(Jianghong Rao and Stoyanova Tanya Project Leads)

Year 4

Pilot Project 8 
Nanoscale FTIR Spectromicroscopic Characterization of Tumor Exosomes and their Effects on Neighboring Cells in Real-time

(Francis Blankenberg and Derek Rudolf Holman Project Leads)


Pilot Project 9
Activation of endogenous tumor infiltrating antigen-specific CD8+ T cells by polymeric nanoparticles for enhanced cancer immunotherapy
(Mark Davis and Qian Yin Project Leads)