Center for Cancer Nanotechnology Excellence
and Translation (CCNE-T)

Research Highlights

Project 1
Smith B.R., Ghosn E., Rallapalli H., Prescher J., Larson T., Herzenberg L., Gambhir S.S. Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery. Nature Nanotechnology, 2014, In Press.  PMCID in progress.

Smith B.R., Zavaleta C., Liu Z., Tong R., Ramunas J., Dai H., Gambhir S.S. High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model. Nano Today, 2013; 8(2):126-137. PMCID in progress.

Project 2
Zhang M., Xie X., Tang M., Criddle C.S., Cui Y., Wang S.X., Magnetically ultra-responsive nanoscavengers for next-generation water purification systems. Nature Communications, 2013, 4: 1866.PMCID in progress.

Zhang M., Bechstein D.J.B., Wilson R.J., and Wang S.X, Wafer-scale synthesis of monodisperse synthetic magnetic multilayer nanorods, Nano Letter2014; 14(1): 333-8. PMID: 234329003. PMCID in progress.

Widney, D.P., Olafsen, T., Wu, A.M., Kitchen, C.M.R., Said, J.W., Smith, J.B., Pena, G., Magpantay, L., and Martinez-Maza, O. Levels of murine, but not human, CXCL13 are greatly elevated in a NOD-SCID mice bearing the AIDS-associated Burkitt Lymphoma cell line, 2F7.  PLoSOne, 2013, 8:e72414. PMCID: PMC3732224.

Tavaré, R., McCracken, M.N., Zettlitz, K.A., Knowles, S.M., Salazar, F.B., Olafsen, T., Witte, O.N. and Wu, A.M.  Engineered antibody fragments for immunoPET imaging of endogenous CD8 T cells in vivo.  Proc. Nat. Acad. Sci.  Accepted 2014. PMCID in progress.

Project 3
Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang JH, Hecht VC, Winslow MM, Jacks T, Mallick P, Manalis SR. Characterizing deformability and surface friction of cancer cells. Proc. Nat. Acad. Sci. of the USA, 2013; 110(19): 7580-5.  PMCID: PMC3651488.

Wu A.R., Neff N.F.,Kalisky T., Dalerba P., Barbara Treutlein, Rothenberg M.E., Mburu F.M., Mantalas G.L., Sim S., Clarke M.F. and Quake S.R. Quantitative assessment of single-cell RNA-sequencing methods, Nature Methods, 2013; 11: 41-6. PMCID in progress.

Project 4
Smith B.R., Kempen P., Bouley D., Xu A., Liu Z., Melosh N., Dai H., Sinclair R, and Gambhir SS. Shape matters: intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation. Nano Letters. 2013, 12(7): 3369-3377. PMCID in Progress.

Ziv K., Gambhir S.S. Bioengineering and regenerative medicine: Keeping track. Nature Materials. 2013; 12(3):180-1. PMCID in progress.

Bohndiek, S. E., Bodapati S., Van De Sompei D., Kothapalli S-R., Gambhir S.S. Development and Application of Stable Phantoms for the Evaluation of Photoacoustic Imaging Instruments. PLoS One. 2013, 8(9): e75533.  PMCID in progress.

Nair, V.S., Keu K.V., Luttgen M.S., Kolatkar A., Vasanawala M., Kuschner W., Bethel K., Iagaru A.H., Hoh C., Shrager J.B., Loo, B.W. Jr., Bazhenova L., Nieva J., Gambhir S.S. and Kuhn P. An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer. PLoS One. 2013, 8(7): e67733. PMCID in progress.

Salm, E., Duarte C., Dak P., Dorvel B., Reddy Jr. B., Alam A., and Bashir R. Ultra-localized Thermal Reactions in Sub-Nanoliter Droplets-in-Air. PNAS. 2013, 110: 3310-3315. PMCID in progress.

Zavaleta, C.L., Garai E., Liu J.T., Sensam S., Mandella M.J., Van De Sompei, D., Friedland S., Van Dam J., Contag C.H., and Gambhir S.S. A Raman-based endoscopic strategy for multiplexed molecular imaging. PNAS. 2013, 110(25): E2288-E2297. PMCID in progress.