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Those with aging immune systems struggle to fight off novel viruses and respond weakly to vaccination. Stanford Medicine researchers were able to revitalize the immune system in mice.

A drug that boosts strength in injured or aging mice restores connections between nerves and muscle and suggests ways to combat weakness in humans due to aging, injury or disease.

A study in mice finds that white matter — the tissue that transmits messages around the brain — shows the greatest changes as the animals age.

Old muscle stem cells express high levels of the cancer-associated molecule CD47. Blocking a pathway mediated by CD47 restored strength to old mice in a Stanford Medicine study.

Researchers have identified a mechanism underlying fragmented sleep with older age, paving the way for potential drug therapies.

Researchers have found that old skeletal stem cells contribute to bone fragility and poor healing in mice, but that a stem cell-boosting gel may help restore function.

Scientists have identified a key factor in mental aging and shown that it might be prevented or reversed by fixing a glitch in the immune system’s front-line soldiers.

A single protein is a master regulator of mouse muscle function during aging, a Stanford study finds. Blocking this protein increased muscle strength and endurance in old animals. It may play a role in age-related muscle weakening in humans.

Annelise Barron, Peter Kim, Siddhartha Jaiswal and Keren Haroush will receive grants totaling $10 million to fund their investigations. The awards support risky efforts that could potentially have a big impact in the biomedical sciences.

In laboratory studies, Stanford School of Medicine researchers have found a way to regenerate the cartilage that eases movement between bones.