Mohsen Afshar awarded SUMS Seed Grant

Postdoctoral fellow Mohsen Afshar was awarded a SUMS Seed Grant for his proposal Quantifying cellular NAD+ metabolome using a liquid chromatography coupled to mass spectrometry approach. NAD+ is known to be a key regulator of metabolism and longevity. Aging is accompanied by changes in NAD+ metabolome. The Blau Lab has recently identified a novel target, 15-PGDH, that acts as a master regulator of muscle rejuvenation in aged mice by restoring mitochondrial activity. This proposal allows development of a novel method to measure key components of NAD+ metabolome in aged mouse muscles post 15-PGDH inhibition.