Publications

2023

Progress and challenges in stem cell biology.

Apostolou, E., Blau, HM, Chien, K, Lancaster, MA, Rao Tata, P, Trompouki, E, Watt, FM, Zeng, YA, Zernicka-Goetz, M. Nat Cell Biol. 2023 Feb;25(2):203-206. doi: 10.1038/s41556-023-01087-y. PMID: 36788378.

Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors.

Togninalli M, Ho ATV, Madl CM, Holbrook CA, Wang YX, Magnusson KEG, Kirillova A, Chang A, Blau HM. NPJ Regen Med. 2023 Jan 14;8(1):4. doi: 10.1038/s41536-023-00277-4. PMID: 36639373.

TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs.

Eguchi A, Gonzalez AFGS, Torres-Bigio SI, Koleckar K, Birnbaum F, Zhang JZ, Wang VY, Wu JC, Artandi SE, Blau HM. Proc Natl Acad Sci USA. 2023 Feb 7;120(6):e2209967120. doi: 10.1073/pnas.2209967120. Epub 2023 Jan 31. PMID: 36719921.

Spatial compartmentalization of signaling imparts source-specific functions on secreted factors.

Groppa E, Martini P, Derakhshan N, Theret M, Ritso M, Tung LW, Wang YX, Soliman H, Hamer MS, Stankiewicz L, Eisner C, Erwan LN, Chang C, Yi L, Yuan JH, Kong S, Weng C, Adams J, Chang L, Peng A, Blau HM, Romualdi C, Rossi FMV. Cell Rep. 2023 Jan 31;42(2):112051. doi: 10.1016/j.celrep.2023.112051. PMID: 36729831.

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.

Danielli SG, Porpiglia E, De Micheli AJ, Navarro N, Zellinger MJ, Bechtold I, Kisele S, Volken L, Marques JG, Kasper S, Bode PK, Henssen AG, Gürgen D, Delattre O, Surdez D, Roma J, Bühlmann P, Blau HM, Wachtel M, Schäfer BW. Sci Adv. 2023 Feb 10;9(6):eade9238. doi: 10.1126/sciadv.ade9238. Epub 2023 Feb 8. PMID: 36753540.

Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression.

Zengel J, Wang YX, Seo JW, Ning K, Hamilton JN, Wu B, Raie M, Holbrook C, Su S, Clements DR, Pillay S, Puschnik AS, Winslow MM, Idoyaga J, Nagamine CM, Sun Y, Mahajan VB, Ferrara KW, Blau HM, Carette JE. Nat Methods. 2023 Jul;20(7):1070-1081. doi: 10.1038/s41592-023-01896-x. Epub 2023 Jun 8. PMID: 37291262.

2022

Elevated CD47 is a Hallmark of Dysfunctional Aged Muscle Stem Cells that can be Targeted to Augment Regeneration.

Porpiglia E, Mai T, Kraft P, Holbrook C, de Morree A, Gonzalez V, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM. Cell Stem Cell. 2022 Dec 1;29(12):1653-1668.e8.. doi: 10.1016/j.stem.2022.10.009. PMID: 36384141

Plasticity of Muscle Stem Cells in Homeostasis and Aging.

Porpiglia E, Blau HM. Current Opinion in Genetics and Development. 2022 Vol 77, 101999. https://doi.org/10.1016/j.gde.2022.101999. PMID: 36308777

Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation.

Scanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Scientific Reports. 2022 12, 16218. https://doi.org/10.1038/s41598-022-19013-x. PMID: 36171423

Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates.

Birnbaum F, Eguchi A, Pardon G, Chang ACY, Blau HM. NPJ Regen Med. 2022 Mar 18;7(1):19. doi: 10.1038/s41536-022-00214-x.PMID: 35304486

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging.

Palla AR, Hilgendorf KI, Yang AV, Kerr JP, Hinken AC, Demeter J, Kraft P, Mooney NA, Yucel N, Burns DM, Wang YX, Jackson PK, Blau HM. Nat Commun. 2022 Mar 17;13(1):1439. doi: 10.1038/s41467-022-29150-6.PMID: 35301320

2021

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.

Palla AR, Ravichandran M, Wang YX, Alexandrova L, Yang AV, Kraft P, Holbrook CA, Schürch CM, Ho ATV, Blau HM. Science. 2021 Jan 29;371(6528):eabc8059. doi: 10.1126/science.abc8059. Epub 2020 Dec 10. PMID: 33303683

Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes

Chang ACY, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL, Blau HM. Stem Cell Reports. 2021 May 11:S2213-6711(21)00213-7. doi: 10.1016/j.stemcr.2021.04.018. PMID: 34019816

AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency.

Markov GJ, Mai T, Nair S, Shcherbina A, Wang YX, Burns DM, Kundaje A, Blau HM. Proc Natl Acad Sci USA. 2021 Jun 8;118(23):e2104841118. doi: 10.1073/pnas.2104841118.PMID: 34088849

Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments

Madl CM, Flaig IA, Holbrook CA, Wang YX, Blau HM. Biomaterials. 2021 Jun 14;275:120973. doi: 10.1016/j.biomaterials.2021.120973. PMID: 34224984

Reversing aging for heart repair

Wang YX and Blau HM. Science. 24 Sep 2021. Vol 373, Issue 6562 pp. 1439-1440. Link.

2020

Tissue Stem Cells: Architects of Their Niches.

Fuchs E, Blau HM. Cell Stem Cell. 2020 Oct 1;27(4):532-556. doi: 10.1016/j.stem.2020.09.011. PMID: 33007238 Review.

An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics.

Chang ACY, Chang ACH, Nicin L, Weber GJ, Holbrook C, Davies MF, Blau HM, Bertaccini EJ. Anesth Analg. 2020 Jan;130(1):e1-e4. doi: 10.1213/ANE.0000000000003757. PMID: 30198930

Farewell to Professor David Yaffe - A pillar of the myogenesis field.

Yablonka-Reuveni Z, Stockdale F, Nudel U, Israeli D, Blau HM, Shainberg A, Neuman S, Kessler-Icekson G, Krull EM, Paterson B, Fuchs OS, Greenberg D, Sarig R, Halevy O, Ozawa E, Katcoff DJ. Eur J Transl Myol. 2020 Aug 18;30(3):9306. doi: 10.4081/ejtm.2020.9306. eCollection 2020 Sep 30. PMID: 33117511

A Clock that Controls Human Spine Development

Palla, A, Blau HM. Nature. 2020 April 2. Vol 580, pg 32. PMID 32238938

2019

Stem Cells in the Treatment of Disease.

Blau HM, Daley GQ. N Engl J Med. 2019 May 2;380(18):1748-1760. doi: 10.1056/NEJMra1716145. PMID: 31042827 Review.

Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.

Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC. Eur Heart J. 2019 Dec 1;40(45):3685-3695. doi: 10.1093/eurheartj/ehz326. PMID: 31219556

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function.

Yucel N, Wang YX, Mai T, Porpiglia E, Lund PJ, Markov G, Garcia BA, Bendall SC, Angelo M, Blau HM. Cell Rep. 2019 Jun 25;27(13):3939-3955.e6. doi: 10.1016/j.celrep.2019.05.092. PMID: 31242425

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.

Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC. Cell Stem Cell. 2019 May 2;24(5):802-811.e5. doi: 10.1016/j.stem.2019.02.015. Epub 2019 Mar 14. PMID: 30880024

2018

Bioengineering strategies to accelerate stem cell therapeutics.

Madl CM, Heilshorn SC, Blau HM. Nature. 2018 May;557(7705):335-342. doi: 10.1038/s41586-018-0089-z. Epub 2018 May 16. PMID: 29769665. Review.

Telomere shortening is a hallmark of genetic cardiomyopathies.

Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, Ashley E, Wu JC, Blau HM. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9276-9281. doi: 10.1073/pnas.1714538115. Epub 2018 Aug 27. PMID: 30150400

Short telomeres - A hallmark of heritable cardiomyopathies.

Chang ACY, Blau HM. Differentiation. 2018 Mar-Apr;100:31-36. doi: 10.1016/j.diff.2018.02.001. Epub 2018 Feb 9.
PMID: 29482077. Review.

Macrophages rescue injured engineered muscle.

Wang YX, Blau HM. Nat Biomed Eng. 2018 Dec;2(12):890-891. doi: 10.1038/s41551-018-0312-0. PMID: 31015725

Muscling toward therapy with ERBB3 and NGFR.

Ho ATV, Blau HM. Nat Cell Biol. 2018 Jan;20(1):6-7. doi: 10.1038/s41556-017-0015-x. PMID: 29269948

Humanizing the mdx mouse model of DMD: the long and the short of it.

Yucel N, Chang AC, Day JW, Rosenthal N, Blau HM. NPJ Regen Med. 2018 Feb 16;3:4. doi: 10.1038/s41536-018-0045-4. eCollection 2018. PMID: 29479480. Review.

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M.

Sampath SC, Sampath SC, Ho ATV, Corbel SY, Millstone JD, Lamb J, Walker J, Kinzel B, Schmedt C, Blau HM. Nat Commun. 2018 Apr 18;9(1):1531. doi: 10.1038/s41467-018-03876-8. PMID: 29670077

A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells.

Tichy ED, Sidibe DK, Greer CD, Oyster NM, Rompolas P, Rosenthal NA, Blau HM, Mourkioti F. Skelet Muscle. 2018 Aug 24;8(1):27. doi: 10.1186/s13395-018-0169-7. PMID: 30139374

NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and human iPSC induction.

Mai T, Markov GJ, Brady JJ, Palla A, Zeng H, Sebastiano V, Blau HM. Nat Cell Biol. 2018 Aug;20(8):900-908. doi: 10.1038/s41556-018-0136-x. Epub 2018 Jul 16. PMID: 30013107

Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9182-E9191. doi: 10.1073/pnas.1808648115. Epub 2018 Sep 4. PMID: 30181272

An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics.

Chang ACY, Chang ACH, Nicin L, Weber GJ, Holbrook C, Davies MF, Blau HM, Bertaccini EJ. Anesth Analg. 2020 Jan;130(1):e1-e4. doi: 10.1213/ANE.0000000000003757. PMID: 30198930

Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9182-E9191. doi: 10.1073/pnas.1808648115. Epub 2018 Sep 4. PMID: 30181272

2017

Dermatologist-level classification of skin cancer with deep neural networks.

Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S. Nature. 2017 Feb 2;542(7639):115-118. doi: 10.1038/nature21056. Epub 2017 Jan 25. PMID: 28117445

High-resolution myogenic lineage mapping by single-cell mass cytometry.

Porpiglia E, Samusik N, Ho ATV, Cosgrove BD, Mai T, Davis KL, Jager A, Nolan GP, Bendall SC, Fantl WJ, Blau HM.Nat Cell Biol. 2017 May;19(5):558-567. doi: 10.1038/ncb3507. Epub 2017 Apr 17.PMID: 28414312

Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.

Ho ATV, Palla AR, Blake MR, Yucel ND, Wang YX, Magnusson KEG, Holbrook CA, Kraft PE, Delp SL, Blau HM. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6675-6684. doi: 10.1073/pnas.1705420114. Epub 2017 Jun 12. PMID: 28607093

An objective comparison of cell-tracking algorithms.

Ulman V, Maška M, Magnusson KEG, Ronneberger O, Haubold C, Harder N, Matula P, Matula P, Svoboda D, Radojevic M, Smal I, Rohr K, Jaldén J, Blau HM, Dzyubachyk O, Lelieveldt B, Xiao P, Li Y, Cho SY, Dufour AC, Olivo-Marin JC, Reyes-Aldasoro CC, Solis-Lemus JA, Bensch R, Brox T, Stegmaier J, Mikut R, Wolf S, Hamprecht FA, Esteves T, Quelhas P, Demirel Ö, Malmström L, Jug F, Tomancak P, Meijering E, Muñoz-Barrutia A, Kozubek M, Ortiz-de-Solorzano C. Nat Methods. 2017 Dec;14(12):1141-1152. doi: 10.1038/nmeth.4473. Epub 2017 Oct 30. PMID: 29083403

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons.

Wong WT, Matrone G, Tian X, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP. Elife. 2017 Mar 21;6:e23588. doi: 10.7554/eLife.23588. PMID: 28323620

Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation.

Sleep E, Cosgrove BD, McClendon MT, Preslar AT, Chen CH, Sangji MH, Pérez CMR, Haynes RD, Meade TJ, Blau HM, Stupp SI. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7919-E7928. doi: 10.1073/pnas.1708142114. Epub 2017 Sep 5. PMID: 28874575

Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency.

Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D. J Clin Invest. 2017 May 1;127(5):1683-1688. doi: 10.1172/JCI90338. Epub 2017 Mar 27. PMID: 28346225

Corrigendum: Dermatologist-level classification of skin cancer with deep neural networks.

Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S. Nature. 2017 Jun 28;546(7660):686. doi: 10.1038/nature22985. PMID: 28658222

2016

Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.

Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Nat Med. 2016 May;22(5):547-56. doi: 10.1038/nm.4087. Epub 2016 Apr 18. PMID: 27089514

Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy.

Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13120-13125. doi: 10.1073/pnas.1615340113. Epub 2016 Oct 31. PMID: 27799523

Noninvasive Tracking of Quiescent and Activated Muscle Stem Cell (MuSC) Engraftment Dynamics In Vivo.

Ho AT, Blau HM. Methods Mol Biol. 2016;1460:181-9. doi: 10.1007/978-1-4939-3810-0_13. PMID: 27492173

2015

The central role of muscle stem cells in regenerative failure with aging.

Blau HM, Cosgrove BD, Ho AT. Nat Med. 2015 Aug;21(8):854-62. doi: 10.1038/nm.3918. PMID: 26248268

Stem Cells and Aging: What's Next?

Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y. Cell Stem Cell. 2015 Jun 4;16(6):578-81. doi: 10.1016/j.stem.2015.05.005. PMID: 26247067

Turning terminally differentiated skeletal muscle cells into regenerative progenitors.

Wang H, Lööf S, Borg P, Nader GA, Blau HM, Simon A. Nat Commun. 2015 Aug 5;6:7916. doi: 10.1038/ncomms8916. PMID: 26243583

Global linking of cell tracks using the Viterbi algorithm.

Magnusson KE, Jalden J, Gilbert PM, Blau HM. IEEE Trans Med Imaging. 2015 Apr;34(4):911-29. doi: 10.1109/TMI.2014.2370951. Epub 2014 Nov 14. PMID: 25415983

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells.

Ramunas J, Yakubov E, Brady JJ, Corbel SY, Holbrook C, Brandt M, Stein J, Santiago JG, Cooke JP, Blau HM. FASEB J. 2015 May;29(5):1930-9. doi: 10.1096/fj.14-259531. Epub 2015 Jan 22. PMID: 25614443

Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice.

Raval A, Behbehani GK, Nguyen le XT, Thomas D, Kusler B, Garbuzov A, Ramunas J, Holbrook C, Park CY, Blau H, Nolan GP, Artandi SE, Mitchell BS. PLoS One. 2015 Jul 2;10(7):e0131722. doi: 10.1371/journal.pone.0131722. eCollection 2015. PMID: 26133370

2014

Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein.

Chu J, Haynes RD, Corbel SY, Li P, González-González E, Burg JS, Ataie NJ, Lam AJ, Cranfill PJ, Baird MA, Davidson MW, Ng HL, Garcia KC, Contag CH, Shen K, Blau HM, Lin MZ. Nat Methods. 2014 May;11(5):572-8. doi: 10.1038/nmeth.2888. Epub 2014 Mar 16. PMID: 24633408

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.

Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM. Nat Med. 2014 Mar;20(3):255-64. doi: 10.1038/nm.3464. Epub 2014 Feb 16. PMID: 24531378

Objective comparison of particle tracking methods.

Chenouard N, Smal I, de Chaumont F, Maška M, Sbalzarini IF, Gong Y, Cardinale J, Carthel C, Coraluppi S, Winter M, Cohen AR, Godinez WJ, Rohr K, Kalaidzidis Y, Liang L, Duncan J, Shen H, Xu Y, Magnusson KE, Jaldén J, Blau HM, Paul-Gilloteaux P, Roudot P, Kervrann C, Waharte F, Tinevez JY, Shorte SL, Willemse J, Celler K, van Wezel GP, Dan HW, Tsai YS, Ortiz de Solórzano C, Olivo-Marin JC, Meijering E. Nat Methods. 2014 Mar;11(3):281-9. doi: 10.1038/nmeth.2808. Epub 2014 Jan 19. PMID: 24441936

Sir John Gurdon: father of nuclear reprogramming.

Blau HM. Differentiation. 2014 Jul;88(1):10-12. doi: 10.1016/j.diff.2014.05.002. Epub 2014 Jun 18. PMID: 24954777

A benchmark for comparison of cell tracking algorithms.

Maška M, Ulman V, Svoboda D, Matula P, Matula P, Ederra C, Urbiola A, España T, Venkatesan S, Balak DM, Karas P, Bolcková T, Streitová M, Carthel C, Coraluppi S, Harder N, Rohr K, Magnusson KE, Jaldén J, Blau HM, Dzyubachyk O, Křížek P, Hagen GM, Pastor-Escuredo D, Jimenez-Carretero D, Ledesma-Carbayo MJ, Muñoz-Barrutia A, Meijering E, Kozubek M, Ortiz-de-Solorzano C. Bioinformatics. 2014 Jun 1;30(11):1609-17. doi: 10.1093/bioinformatics/btu080. Epub 2014 Feb 12. PMID: 24526711

Global linking of cell tracks using the Viterbi algorithm.

Magnusson KE, Jalden J, Gilbert PM, Blau HM. IEEE Trans Med Imaging. 2015 Apr;34(4):911-29. doi: 10.1109/TMI.2014.2370951. Epub 2014 Nov 14. PMID: 25415983

Perspective for special Gurdon issue for differentiation: can cell fusion inform nuclear reprogramming?

Burns D, Blau HM. Differentiation. 2014 Jul;88(1):27-28. doi: 10.1016/j.diff.2014.07.001. Differentiation 2014 Aug 21. PMID: 25150886

Simultaneous silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic islets.

Tamaki S, Nye C, Slorach E, Scharp D, Blau HM, Whiteley PE, Pomerantz JH. BMC Biotechnol. 2014 Oct 11;14:86. doi: 10.1186/1472-6750-14-86. PMID: 25305068

2013

Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq.

Brady JJ, Li M, Suthram S, Jiang H, Wong WH, Blau HM. Nat Cell Biol. 2013 Oct;15(10):1244-52. doi: 10.1038/ncb2835. Epub 2013 Sep 1. PMID: 23995732

An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis.

Oliver SL, Brady JJ, Sommer MH, Reichelt M, Sung P, Blau HM, Arvin AM. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1911-6. doi: 10.1073/pnas.1216985110. Epub 2013 Jan 15. PMID: 23322733

A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells.

Bhutani N, Decker MN, Brady JJ, Bussat RT, Burns DM, Corbel SY, Blau HM. FASEB J. 2013 Mar;27(3):1107-13. doi: 10.1096/fj.12-222125. Epub 2012 Dec 4. PMID: 23212122

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy.

Mourkioti F, Kustan J, Kraft P, Day JW, Zhao MM, Kost-Alimova M, Protopopov A, DePinho RA, Bernstein D, Meeker AK, Blau HM. Nat Cell Biol. 2013 Aug;15(8):895-904. doi: 10.1038/ncb2790. Epub 2013 Jul 7. PMID: 23831727

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases.

Tremblay JP, Xiao X, Aartsma-Rus A, Barbas C, Blau HM, Bogdanove AJ, Boycott K, Braun S, Breakefield XO, Bueren JA, Buschmann M, Byrne BJ, Calos M, Cathomen T, Chamberlain J, Chuah M, Cornetta K, Davies KE, Dickson JG, Duchateau P, Flotte TR, Gaudet D, Gersbach CA, Gilbert R, Glorioso J, Herzog RW, High KA, Huang W, Huard J, Joung JK, Liu D, Liu D, Lochmüller H, Lustig L, Martens J, Massie B, Mavilio F, Mendell JR, Nathwani A, Ponder K, Porteus M, Puymirat J, Samulski J, Takeda S, Thrasher A, VandenDriessche T, Wei Y, Wilson JM, Wilton SD, Wolfe JH, Gao G. Mol Ther. 2013 Feb;21(2):266-8. doi: 10.1038/mt.2013.4. PMID: 23369965

Tumor suppressors: enhancers or suppressors of regeneration?

Pomerantz JH, Blau HM. Development. 2013 Jun;140(12):2502-12. doi: 10.1242/dev.084210. PMID: 23715544

2012

A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells.

Bhutani N, Decker MN, Brady JJ, Bussat RT, Burns DM, Corbel SY, Blau HM. FASEB J. 2013 Mar;27(3):1107-13. doi: 10.1096/fj.12-222125. Epub 2012 Dec 4. PMID: 23212122

Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB.

Banfi A, von Degenfeld G, Gianni-Barrera R, Reginato S, Merchant MJ, McDonald DM, Blau HM. FASEB J. 2012 Jun;26(6):2486-97. doi: 10.1096/fj.11-197400. Epub 2012 Mar 5. PMID: 22391130

Protein-engineered biomaterials to generate human skeletal muscle mimics.

Sengupta D, Gilbert PM, Johnson KJ, Blau HM, Heilshorn SC. Adv Healthc Mater. 2012 Nov;1(6):785-9. doi: 10.1002/adhm.201200195. Epub 2012 Sep 5. PMID: 23184832

A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal.

Gilbert PM, Corbel S, Doyonnas R, Havenstrite K, Magnusson KE, Blau HM. Integr Biol (Camb). 2012 Apr;4(4):360-7. doi: 10.1039/c2ib00148a. Epub 2012 Feb 10. PMID: 22327505

Redefining differentiation: Reshaping our ends.

Blau HM. Nat Cell Biol. 2012 May 30;14(6):558. doi: 10.1038/ncb2506. PMID: 22643873

2011

Nanogel star polymer architectures: a nanoparticle platform for modular programmable macromolecular self-assembly, intercellular transport, and dual-mode cargo delivery.

Lee VY, Havenstrite K, Tjio M, McNeil M, Blau HM, Miller RD, Sly J. Adv Mater. 2011 Oct 18;23(39):4509-15. doi: 10.1002/adma.201102371. Epub 2011 Sep 8. PMID: 21901765

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.

Gibbs KD Jr, Gilbert PM, Sachs K, Zhao F, Blau HM, Weissman IL, Nolan GP, Majeti R. Blood. 2011 Apr 21;117(16):4226-33. doi: 10.1182/blood-2010-07-298232. Epub 2011 Feb 28. PMID: 21357764

Structure-function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropism.

Vleck SE, Oliver SL, Brady JJ, Blau HM, Rajamani J, Sommer MH, Arvin AM. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18412-7. doi: 10.1073/pnas.1111333108. Epub 2011 Oct 24. PMID: 22025718

MicroRNA programs in normal and aberrant stem and progenitor cells.

Arnold CP, Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C, Chen CZ. Genome Res. 2011 May;21(5):798-810. doi: 10.1101/gr.111385.110. Epub 2011 Mar 30. PMID: 21451113

Re"evolutionary" regenerative medicine.

Blau HM, Pomerantz JH. JAMA. 2011 Jan 5;305(1):87-8. doi: 10.1001/jama.2010.1938. Epub 2010 Dec 21. PMID: 21177496

Engineering a stem cell house into a home.

Gilbert PM, Blau HM. Stem Cell Res Ther. 2011 Jan 31;2(1):3. doi: 10.1186/scrt44. PMID: 21345268

DNA demethylation dynamics.

Bhutani N, Burns DM, Blau HM. Cell. 2011 Sep 16;146(6):866-72. doi: 10.1016/j.cell.2011.08.042. PMID: 21925312

2010

skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration.

Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20750-5. doi: 10.1073/pnas.1013493107. Epub 2010 Nov 11. PMID: 21071677

Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle.

Pajcini KV, Corbel SY, Sage J, Pomerantz JH, Blau HM. Cell Stem Cell. 2010 Aug 6;7(2):198-213. doi: 10.1016/j.stem.2010.05.022. PMID: 20682446

Reprogramming towards pluripotency requires AID-dependent DNA demethylation.

Bhutani N, Brady JJ, Damian M, Sacco A, Corbel SY, Blau HM. Nature. 2010 Feb 25;463(7284):1042-7. doi: 10.1038/nature08752. PMID: 20027182

Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions.

Koshy AA, Fouts AE, Lodoen MB, Alkan O, Blau HM, Boothroyd JC. Nat Methods. 2010 Apr;7(4):307-9. doi: 10.1038/nmeth.1438. Epub 2010 Mar 7. PMID: 20208532

Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice.

Sacco A, Mourkioti F, Tran R, Choi J, Llewellyn M, Kraft P, Shkreli M, Delp S, Pomerantz JH, Artandi SE, Blau HM. Cell. 2010 Dec 23;143(7):1059-71. doi: 10.1016/j.cell.2010.11.039. Epub 2010 Dec 9. PMID: 21145579

Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture.

Gilbert PM, Havenstrite KL, Magnusson KE, Sacco A, Leonardi NA, Kraft P, Nguyen NK, Thrun S, Lutolf MP, Blau HM. Science. 2010 Aug 27;329(5995):1078-81. doi: 10.1126/science.1191035. Epub 2010 Jul 15. PMID: 20647425

Nuclear reprogramming to a pluripotent state by three approaches.

Yamanaka S, Blau HM. Nature. 2010 Jun 10;465(7299):704-12. doi: 10.1038/nature09229. PMID: 20535199

2009

Perturbation of single hematopoietic stem cell fates in artificial niches.

Lutolf MP, Doyonnas R, Havenstrite K, Koleckar K, Blau HM. Integr Biol (Camb). 2009 Jan;1(1):59-69. doi: 10.1039/b815718a. Epub 2008 Nov 21. PMID: 20023792

Imaging beta-galactosidase activity in vivo using sequential reporter-enzyme luminescence.

von Degenfeld G, Wehrman TS, Blau HM. Methods Mol Biol. 2009;574:249-59. doi: 10.1007/978-1-60327-321-3_20. PMID: 19685314

Reprogramming to a muscle fate by fusion recapitulates differentiation.

Pomerantz JH, Mukherjee S, Palermo AT, Blau HM. J Cell Sci. 2009 Apr 1;122(Pt 7):1045-53. doi: 10.1242/jcs.041376. PMID: 19295131

Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional.

Palermo A, Doyonnas R, Bhutani N, Pomerantz J, Alkan O, Blau HM. FASEB J. 2009 May;23(5):1431-40. doi: 10.1096/fj.08-122903. Epub 2009 Jan 13. PMID: 19141533

A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches.

Cosgrove BD, Sacco A, Gilbert PM, Blau HM. Differentiation. 2009 Sep-Oct;78(2-3):185-94. doi: 10.1016/j.diff.2009.08.004. PMID: 19751902

Artificial stem cell niches.

Lutolf MP, Blau HM. Adv Mater. 2009 Sep 4;21(32-33):3255-68. doi: 10.1002/adma.200802582. PMID: 20882496

Designing materials to direct stem-cell fate.

Lutolf MP, Gilbert PM, Blau HM. Nature. 2009 Nov 26;462(7272):433-41. doi: 10.1038/nature08602. PMID: 19940913

2008

Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation.

Johansson CB, Youssef S, Koleckar K, Holbrook C, Doyonnas R, Corbel SY, Steinman L, Rossi FM, Blau HM. Nat Cell Biol. 2008 May;10(5):575-83. doi: 10.1038/ncb1720. Epub 2008 Apr 20. PMID: 18425116

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L. Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1614-20. doi: 10.1161/ATVBAHA.107.158725. Epub 2008 May 29. PMID: 18511699

Myoblasts and macrophages share molecular components that contribute to cell-cell fusion.

Pajcini KV, Pomerantz JH, Alkan O, Doyonnas R, Blau HM. J Cell Biol. 2008 Mar 10;180(5):1005-19. doi: 10.1083/jcb.200707191. PMID: 18332221

Perturbation of single hematopoietic stem cell fates in artificial niches.

Lutolf MP, Doyonnas R, Havenstrite K, Koleckar K, Blau HM. Integr Biol (Camb). 2009 Jan;1(1):59-69. doi: 10.1039/b815718a. Epub 2008 Nov 21. PMID: 20023792

Cell therapies for muscular dystrophy.

Blau HM. N Engl J Med. 2008 Sep 25;359(13):1403-5. doi: 10.1056/NEJMcibr0805708. PMID: 18815403

Self-renewal and expansion of single transplanted muscle stem cells.

Sacco A, Doyonnas R, Kraft P, Vitorovic S, Blau HM. Nature. 2008 Nov 27;456(7221):502-6. doi: 10.1038/nature07384. Epub 2008 Sep 17. PMID: 18806774

Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells.

Streetz KL, Doyonnas R, Grimm D, Jenkins DD, Fuess S, Perryman S, Lin J, Trautwein C, Shizuru J, Blau H, Sylvester KG, Kay MA. Hepatology. 2008 Feb;47(2):706-18. doi: 10.1002/hep.22012. PMID: 18220289

2007

Anne McLaren (1927-2007).

Blau HM. Differentiation. 2007 Dec;75(10):899-901. doi: 10.1111/j.1432-0436.2007.00248.x. PMID: 18076565

A universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals.

von Degenfeld G, Wehrman TS, Hammer MM, Blau HM. FASEB J. 2007 Dec;21(14):3819-26. doi: 10.1096/fj.07-9597com. Epub 2007 Oct 17. PMID: 17942828

Increased host neuronal survival and motor function in BMT Parkinsonian mice: involvement of immunosuppression.

Keshet GI, Tolwani RJ, Trejo A, Kraft P, Doyonnas R, Clayberger C, Weimann JM, Blau HM. J Comp Neurol. 2007 Oct 20;504(6):690-701. doi: 10.1002/cne.21483. PMID: 17722033

Localization of vascular response to VEGF is not dependent on heparin binding.

Springer ML, Banfi A, Ye J, von Degenfeld G, Kraft PE, Saini SA, Kapasi NK, Blau HM. FASEB J. 2007 Jul;21(9):2074-85. doi: 10.1096/fj.06-7700com. Epub 2007 Feb 26. PMID: 17325231

Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons.

Zhang F, Pomerantz JH, Sen G, Palermo AT, Blau HM. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4395-400. doi: 10.1073/pnas.0700181104. Epub 2007 Mar 7. PMID: 17360535

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M. Nat Chem Biol. 2007 Oct;3(10):668-77. doi: 10.1038/nchembio.2007.26. Epub 2007 Sep 9. PMID: 17828252

In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts.

Kutschka I, Chen IY, Kofidis T, von Degenfeld G, Sheikh AY, Hendry SL, Hoyt G, Pearl J, Blau HM, Gambhir SS, Robbins RC. J Heart Lung Transplant. 2007 Mar;26(3):273-80. doi: 10.1016/j.healun.2006.11.604. PMID: 17346630

Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation.

Wan DC, Pomerantz JH, Brunet LJ, Kim JB, Chou YF, Wu BM, Harland R, Blau HM, Longaker MT. J Biol Chem. 2007 Sep 7;282(36):26450-9. doi: 10.1074/jbc.M703282200. Epub 2007 Jul 2. PMID: 17609215

A novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization.

Hammer MM, Wehrman TS, Blau HM. FASEB J. 2007 Dec;21(14):3827-34. doi: 10.1096/fj.07-8777com. Epub 2007 Oct 17. PMID: 17942829

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.

Wehrman T, He X, Raab B, Dukipatti A, Blau H, Garcia KC. Neuron. 2007 Jan 4;53(1):25-38. doi: 10.1016/j.neuron.2006.09.034. PMID: 17196528

2006

Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts.

Kutschka I, Kofidis T, Chen IY, von Degenfeld G, Zwierzchoniewska M, Hoyt G, Arai T, Lebl DR, Hendry SL, Sheikh AY, Cooke DT, Connolly A, Blau HM, Gambhir SS, Robbins RC. Circulation. 2006 Jul 4;114(1 Suppl):I174-80. doi: 10.1161/CIRCULATIONAHA.105.001370. PMID: 16820569

Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts.

Kutschka I, Chen IY, Kofidis T, Arai T, von Degenfeld G, Sheikh AY, Hendry SL, Pearl J, Hoyt G, Sista R, Yang PC, Blau HM, Gambhir SS, Robbins RC. Circulation. 2006 Jul 4;114(1 Suppl):I167-73. doi: 10.1161/CIRCULATIONAHA.105.001297. PMID: 16820568

Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia.

von Degenfeld G, Banfi A, Springer ML, Wagner RA, Jacobi J, Ozawa CR, Merchant MJ, Cooke JP, Blau HM. FASEB J. 2006 Dec;20(14):2657-9. doi: 10.1096/fj.06-6568fje. Epub 2006 Nov 9. PMID: 17095533

A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.

Wehrman TS, Raab WJ, Casipit CL, Doyonnas R, Pomerantz JH, Blau HM. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19063-8. doi: 10.1073/pnas.0605218103. Epub 2006 Dec 5. PMID: 17148612

Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence.

Wehrman TS, von Degenfeld G, Krutzik PO, Nolan GP, Blau HM. Nat Methods. 2006 Apr;3(4):295-301. doi: 10.1038/nmeth868. PMID: 16554835

A brief history of RNAi: the silence of the genes.

Sen GL, Blau HM. FASEB J. 2006 Jul;20(9):1293-9. doi: 10.1096/fj.06-6014rev. PMID: 16816104

2005

IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors.

Sacco A, Doyonnas R, LaBarge MA, Hammer MM, Kraft P, Blau HM. J Cell Biol. 2005 Nov 7;171(3):483-92. doi: 10.1083/jcb.200506123. PMID: 16275752

Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.

Jacobi J, Sydow K, von Degenfeld G, Zhang Y, Dayoub H, Wang B, Patterson AJ, Kimoto M, Blau HM, Cooke JP. Circulation. 2005 Mar 22;111(11):1431-8. doi: 10.1161/01.CIR.0000158487.80483.09. PMID: 15781754

Bone marrow contribution to skeletal muscle: a physiological response to stress.

Palermo AT, Labarge MA, Doyonnas R, Pomerantz J, Blau HM. Dev Biol. 2005 Mar 15;279(2):336-44. doi: 10.1016/j.ydbio.2004.12.024. PMID: 15733662

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.

Sen GL, Blau HM. Nat Cell Biol. 2005 Jun;7(6):633-6. doi: 10.1038/ncb1265. Epub 2005 May 22. PMID: 15908945

mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage.

Sen GL, Wehrman TS, Blau HM. Differentiation. 2005 Jul;73(6):287-93. doi: 10.1111/j.1432-0436.2005.00029.x. PMID: 16138829

Optimizing techniques for tracking transplanted stem cells in vivo.

Brazelton TR, Blau HM. Stem Cells. 2005 Oct;23(9):1251-65. doi: 10.1634/stemcells.2005-0149. Epub 2005 Aug 18. PMID: 16109764

Enzymatic detection of protein translocation.

Wehrman TS, Casipit CL, Gewertz NM, Blau HM. Nat Methods. 2005 Jul;2(7):521-7. doi: 10.1038/nmeth771. PMID: 15973423

Critical role of microenvironmental factors in angiogenesis.

Banfi A, von Degenfeld G, Blau HM. Curr Atheroscler Rep. 2005 May;7(3):227-34. doi: 10.1007/s11883-005-0011-7. PMID: 15811258

2004

Restriction enzyme-generated siRNA (REGS) vectors and libraries.

Sen G, Wehrman TS, Myers JW, Blau HM. Nat Genet. 2004 Feb;36(2):183-9. doi: 10.1038/ng1288. Epub 2004 Jan 4. PMID: 14704668

Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis.

Jacobi J, Tam BY, Sundram U, von Degenfeld G, Blau HM, Kuo CJ, Cooke JP. Gene Ther. 2004 Feb;11(3):302-9. doi: 10.1038/sj.gt.3302162. PMID: 14737090

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.

Ozawa CR, Banfi A, Glazer NL, Thurston G, Springer ML, Kraft PE, McDonald DM, Blau HM. J Clin Invest. 2004 Feb;113(4):516-27. doi: 10.1172/JCI18420. PMID: 14966561

Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors.

Doyonnas R, LaBarge MA, Sacco A, Charlton C, Blau HM. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13507-12. doi: 10.1073/pnas.0405361101. Epub 2004 Sep 7. PMID: 15353585

Nuclear reprogramming: a key to stem cell function in regenerative medicine.

Pomerantz J, Blau HM. Nat Cell Biol. 2004 Sep;6(9):810-6. doi: 10.1038/ncb0904-810. PMID: 15340448

2003

Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle.

Springer ML, Ozawa CR, Banfi A, Kraft PE, Ip TK, Brazelton TR, Blau HM. Mol Ther. 2003 Apr;7(4):441-9. doi: 10.1016/s1525-0016(03)00010-8. PMID: 12727106

Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains.

Weimann JM, Charlton CA, Brazelton TR, Hackman RC, Blau HM. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2088-93. doi: 10.1073/pnas.0337659100. Epub 2003 Feb 7. PMID: 12576546

Significant differences among skeletal muscles in the incorporation of bone marrow-derived cells.

Brazelton TR, Nystrom M, Blau HM. Dev Biol. 2003 Oct 1;262(1):64-74. doi: 10.1016/s0012-1606(03)00357-9. PMID: 14512018

Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant.

Weimann JM, Johansson CB, Trejo A, Blau HM. Nat Cell Biol. 2003 Nov;5(11):959-66. doi: 10.1038/ncb1053. Epub 2003 Oct 15. PMID: 14562057

Contribution of hematopoietic stem cells to skeletal muscle.

Corbel SY, Lee A, Yi L, Duenas J, Brazelton TR, Blau HM, Rossi FM. Nat Med. 2003 Dec;9(12):1528-32. doi: 10.1038/nm959. Epub 2003 Nov 16. PMID: 14625543

Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis.

von Degenfeld G, Banfi A, Springer ML, Blau HM. Br J Pharmacol. 2003 Oct;140(4):620-6. doi: 10.1038/sj.bjp.0705492. PMID: 14534145

2002

Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation.

Springer ML, Ozawa CR, Blau HM. Cell Motil Cytoskeleton. 2002 Apr;51(4):177-86. doi: 10.1002/cm.10022. PMID: 11977092

Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury.

LaBarge MA, Blau HM. Cell. 2002 Nov 15;111(4):589-601. doi: 10.1016/s0092-8674(02)01078-4. PMID: 12437931

Protein-protein interactions monitored in mammalian cells via complementation of beta -lactamase enzyme fragments.

Wehrman T, Kleaveland B, Her JH, Balint RF, Blau HM. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3469-74. doi: 10.1073/pnas.062043699. PMID: 11904411

VEGF gene delivery for treatment of ischemic cardiovascular disease.

Koransky ML, Robbins RC, Blau HM. Trends Cardiovasc Med. 2002 Apr;12(3):108-14. doi: 10.1016/s1050-1738(01)00158-x. PMID: 12007735

A twist of fate.

Blau HM. Nature. 2002 Oct 3;419(6906):437. doi: 10.1038/419437a. PMID: 12374136

RIP2, a checkpoint in myogenic differentiation.

Munz B, Hildt E, Springer ML, Blau HM. Mol Cell Biol. 2002 Aug;22(16):5879-86. doi: 10.1128/mcb.22.16.5879-5886.2002. PMID: 12138198

Myoblast-mediated gene transfer for therapeutic angiogenesis.

Banfi A, Springer ML, Blau HM. Methods Enzymol. 2002;346:145-57. doi: 10.1016/s0076-6879(02)46054-5. PMID: 11883066

Gene delivery to muscle.

Springer ML, Rando TA, Blau HM. Curr Protoc Hum Genet. 2002 Feb;Chapter 13:Unit13.4. doi: 10.1002/0471142905.hg1304s31. PMID: 18428326

Something in the eye of the beholder.

Blau H, Brazelton T, Keshet G, Rossi F. Science. 2002 Oct 11;298(5592):361-2; author reply 362-3. PubMed PMID: 12392027

2001

Not the usual suspects: the unexpected sources of tissue regeneration.

Springer ML, Brazelton TR, Blau HM. J Clin Invest. 2001 Jun;107(11):1355-6. doi: 10.1172/JCI13248. PMID: 11390416

Purification of mouse primary myoblasts based on alpha 7 integrin expression.

Blanco-Bose WE, Yao CC, Kramer RH, Blau HM. Exp Cell Res. 2001 May 1;265(2):212-20. doi: 10.1006/excr.2001.5191. PMID: 11302686

Laminin-induced change in conformation of preexisting alpha7beta1 integrin signals secondary myofiber formation.

Blanco-Bose WE, Blau HM. Dev Biol. 2001 May 1;233(1):148-60. doi: 10.1006/dbio.2001.0177. PMID: 11319864

The evolving concept of a stem cell: entity or function?

Blau HM, Brazelton TR, Weimann JM. Cell. 2001 Jun 29;105(7):829-41. doi: 10.1016/s0092-8674(01)00409-3. PMID: 11439179

The well-tempered vessel.

Blau HM, Banfi A. Nat Med. 2001 May;7(5):532-4. doi: 10.1038/87850. PMID: 11329048

In vivo monitoring of myoblast transplantation into rat myocardium.

Koransky ML, Ip TK, Wu S, Cao Y, Berry G, Contag C, Blau H, Robbins R. J Heart Lung Transplant. 2001 Feb;20(2):188-189. PMID: 11250320.

2000-1991

1990-1981