Publications

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.

Palla AR, Ravichandran M, Wang YX, Alexandrova L, Yang AV, Kraft P, Holbrook CA, Schürch CM, Ho ATV, Blau HM. Science. 2021 Jan 29;371(6528):eabc8059. doi: 10.1126/science.abc8059. Epub 2020 Dec 10. PMID: 33303683

Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes

Chang ACY, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL, Blau HM. Stem Cell Reports. 2021 May 11:S2213-6711(21)00213-7. doi: 10.1016/j.stemcr.2021.04.018. PMID: 34019816

AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency.

Markov GJ, Mai T, Nair S, Shcherbina A, Wang YX, Burns DM, Kundaje A, Blau HM. Proc Natl Acad Sci USA. 2021 Jun 8;118(23):e2104841118. doi: 10.1073/pnas.2104841118.PMID: 34088849

Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments

Madl CM, Flaig IA, Holbrook CA, Wang YX, Blau HM. Biomaterials. 2021 Jun 14;275:120973. doi: 10.1016/j.biomaterials.2021.120973. PMID: 34224984

Reversing aging for heart repair

Wang YX and Blau HM. Science. 24 Sep 2021. Vol 373, Issue 6562 pp. 1439-1440. Link.