"Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging" published in Nature Communications

Primary Cilia Schematic

In this collaboration between the Blau and Jackson labs, lead authors Adelaida R. Palla and Keren I. Hilgendorf show that the ability of muscle stem cells to regenerate is regulated by the primary cilium, a cellular protrusion that serves as a sensitive sensory organelle. Their findings provide fresh insights into signaling dysfunction exhibited by aged muscle stem cells and identify the ciliary Hedgehog signaling pathway as a potential therapeutic target to counter the loss of muscle regenerative capacity which accompanies aging.