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Unregulated cell growth seems to be a driver behind the growth of atherosclerotic plaques, changing the traditional story of plaque formation. The rapid cell growth in the arterial wall is similar to pre-cancerous growth in other tissues.

The Stanford developmental biologist was honored for a lifetime of work on the Wnt signaling pathway, which plays an important role in normal development and in cancer.

Stanford Medicine professors Michele Barry, Howard Chang, Thomas Clandinin and Thomas Rando were among the 15 Stanford faculty members elected to the American Academy of Arts and Sciences.

The researchers also identified a molecular pathway involved in turning back the clock on the cells. Drugs that could manipulate the pathway might be an effective substitute for exercise, they suggest.