Research Symposium

Program

08:30AM Continental Breakfast

09:00AM Opening Remarks

• Michael J. Rosen, MD, MSCI, Stanford University Endowed Professor for Pediatric IBD and Celiac Disease; Director, Center for Pediatric IBD and Celiac Disease
• Mary Leonard, MD, MSCE, Arline and Pete Harman Professor of Pediatrics; Chair, Department of Pediatrics

09:15AM-10:15AM Host-Microbe and Intercellular Interactions in IBD and Mucosal Immunity

• Moderator: Stephan Rogalla, MD, PhD, Clinical Assistant Professor of Medicine (Gastroenterology & Hepatology)

09:15AM The Impact of Commensal Eukaryotes on Mucosal Immunity and their implications for IBD Severity

• Michael Howitt, PhD, Assistant Professor of Pathology and of Microbiology and Immunology

09:45AM Single-cell and Spatial Multi-omics to Understand Epithelial Injury in IBD

• Michael Kattah, MD, PhD, Assistant Professor of Medicine, UCSF

10:15AM AM BREAK 

10:30AM-11:40AM Understanding Celiac Disease: Body, Mind, and Microbe

• Moderator: Elizabeth Mellins, MD, Professor of Pediatrics (Human Gene Therapy)

10:30AM Psychological Impacts of Celiac Disease

• Hilary Jericho, MD, MSCI, Clinical Associate Professor of Pediatric Gastroenterology; Director, Stanford Children's Health Celiac Disease Program

11:00AM Keynote Address: The Importance of Adequate Nutrition and The Intestinal Microbiota in the Balance Between Health and Disease Early In Life: The Celiac Disease Paradigm

• Alessio Fasano, MD, W. Allan Walker Chair in Pediatric Gastroenterology and Nutrition; Division Chief, Pediatric Gastroenterology and Nutrition; Director, Center for Celiac Research and Treatment; Director, Mucosal Immunology and Biology Research Center; Associate Chief for Basic, Clinical and Translational Research; Massachusetts General Hospital

11:40AM Refreshments Break

12:00PM-12:40PM The Future of IBD Care and Monitoring

• Moderator: Ruben Colman, MD, PhD, Instructor, Pediatrics- Gastroenterology

12:00PM Keynote Address: C. difficile and IBD

• Maria Oliva-Hemker, MD, Vice Dean for Faculty; Stermer Family Professor of Pediatric Inflammatory Bowel Disease; Division Chief, Pediatric Gastroenterology, Hepatology, and Nutrition; Professor of Pediatrics; Johns Hopkins University School of Medicine

12:40PM Transforming Healthcare with Deep Data and Remote Monitoring 

• Michael Snyder, PhD, Stanford W. Ascherman Professor of Genetics

01:10PM Closing Remarks

• Michael J. Rosen, MD, MSCI, Stanford University Endowed Professor for Pediatric IBD and Celiac Disease; Director, Center for Pediatric IBD and Celiac Disease

01:30 Boxed Lunch 

Program

07:30AM Continental Breakfast

08:15AM Opening Remarks

• Michael Rosen, MD, MSCI, Stanford University Endowed Professor for Pediatric IBD and Celiac Disease; Director, Stanford Medicine Children’s Health Center for IBD and Celiac Disease
• Mary Leonard, MD, MSCE, Arline and Pete Harman Professor of Pediatrics; Chair, Department of Pediatrics
• Sohail Husain, MD, Chambers-Okamura Endowed Professor of Pediatrics; Chief, Division of Gastroenterology, Hepatology, and Nutrition

08:30AM Keynote Address: Regulation of the host-microbiota relationship

• Introduction: Michael Rosen, MD, MSCI, Stanford University Endowed Professor for Pediatric IBD and Celiac Disease; Director, Stanford Medicine Children’s Health Center for IBD and Celiac Disease
• Theresa Alenghat, VMD, PhD, Associate Professor, Department of Pediatrics (Immunobiology), Cincinnati; Children’s Hospital Medical Center

09:15AM Human Autoimmunity

• Introduction: Michael Rosen, MD, MSCI, Stanford University Endowed Professor for Pediatric IBD and Celiac Disease; Director, Stanford Medicine Children’s Health Center for IBD and Celiac Disease
• Mark Davis, PhD, Burt and Marion Avery Family Professor of Microbiology & Immunology; Director, Stanford Institute for Immunity, Transplantation, and Infection 
  • The return of CD8 T cell suppression

09:40AM AM Break

10:00AM Influence of the Microbiome of Health & Disease

• Introduction: Michael Rosen, MD, MSCI, Stanford University Endowed Professor for Pediatric IBD and Celiac Disease; Director, Stanford Medicine Children’s Health Center for IBD and Celiac Disease
• Michael Fischbach, PhD, Associate Professor of Bioengineering and of Medicine
  • 10:10AM-10:35AM Understanding and manipulating immune modulation by the microbiome
• Justin Sonnenburg, PhD, Professor of Microbiology and Immunology
  • 10:35AM-11:00AM Gut microbiome industrialization and the rise of chronic inflammatory disease

11:00AM News Ways of Understanding the Immune Response in Celiac Disease

• Introduction: Nasim Khavari, MD, MPH, Clinical Associate Professor of Pediatrics (Gastroenterology, Hepatology, and Nutrition)
• Elizabeth Mellins, MD, Professor of Pediatrics (Human Gene Therapy)
  • 11:10AM-11:35AM MHCII antigen presentation in autoimmune disease: the celiac disease example
• Calvin Kuo, MD, PhD, Maureen Lyles D’Ambrogio Professor of Medicine (Hematology)
  • 11:35AM-12:00PM Using organoids to model celiac disease and IBD

12:00PM Poster Session & Lunch

01:00PM Immune Therapy and Profiling in IBD 

• Introduction: Alka Goyal, MD, Clinical Professor of Pediatrics (Gastroenterology, Hepatology, and Nutrition); Interim Associate Chief of Clinical Affairs, Division of Gastroenterology, Hepatology, and Nutrition
• Christopher Garcia, PhD, Younger Family Professor of Molecular & Cellular Physiology, and Structural Biology
  • 01:10PM-01:35PM Cytokine engineering for IBD
    • Presented by Robert A. Saxton, PhD, Assistant Professor of Immunology & Molecular Medicine    
• Rosa Bacchetta, MD, Associate Professor of Pediatrics (Stem Cell Transplantation Regenerative Medicine)  
  • 01:35PM-02:00PM Autologous engineered regulatory T cells for pediatric IBD
• Stephan Rogalla, MD, PhD, Clinical Assistant Professor of Medicine (Gastroenterology & Hepatology)
  • 02:00PM-02:25PM High-parameter spatial analysis to improve understanding in IBD
    

02:25PM PM Break

02:40PM Pediatric Gastroenterology Divison Research

• Introduction: Steven Levitte, MD, PhD, Postdoctoral Pediatric Medical Fellow (Gastroenterology, Hepatology, and Nutrition)
• Michael Rosen, MD, MSCI, Stanford University Endowed Professor for Pediatric IBD and Celiac Disease; Director, Stanford Medicine Children’s Health Center for IBD and Celiac Disease
  • Tissue molecular predictors of treatment response in pediatric ulcerative colitis
• Alka Goyal, MD, Clinical Professor of Pediatrics (Gastroenterology, Hepatology, and Nutrition); Interim Associate Chief of Clinical Affairs, Division of Gastroenterology, Hepatology, and Nutrition
  • Bench to bedside: Clinical research studies in IBD

03:40PM PM Break

03:55PM Novel Technologies for Assessing Intestinal Inflammation and Fibrosis

• Introduction: Dylan Dodd, MD, PhD, Assistant Professor of Pathology, of Microbiology & Immunology
• Tom Soh, MS, PhD, Professor of Radiology
  • 04:05PM-04:30PM Technology for continuously measuring specific molecules in vivo
• Jeong Hyun, MD, Assistant Professor of Surgery (Pediatrics)
  • 04:30PM-04:55PM Characterization of creeping fat in intestinal strictures in Crohn’s Disease    
• John Gubatan, MD, Instructor, Medicine (Gastroenterology & Hepatology)
  • 04:55PM-05:20PM Decoding the Adaptive Immune Repertoire with Machine Learning to Predict Biologic Therapy Outcomes in Patients with Pediatric Inflammatory Bowel

05:20PM Closing Remarks & Networking Session

06:00PM Program Ends