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Inadequate removal of uremic solutes contributes to widespread illness in the more than 500,000 Americans maintained on dialysis. But we know remarkably little about these solutes. Dr. Meyer's research efforts are focused on identifying which uremic solutes are toxic, how these solutes are made, and how their production could be decreased or their removal could be increased. We should be able to improve treatment if we knew more about what we are trying to remove.
Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis
Hemodialysis keeps patients with renal failure alive but does not restore normal health.
Retention of chemicals that bind to plasma proteins and are therefore poorly removed by
dialysis may contribute to ill health in patients receiving conventional treatment. This
proposal will test the effect of a new method designed to improve the removal of
protein-bound solutes during dialysis. The effects on blood chemical levels of two different
dialysis prescriptions will be tested in patients already undergoing nocturnal in-center
hemodialysis three times weekly.
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Dietary Maneuvers to Reduce Production of Colon-Derived Uremic Solutes
This study will assess whether dietary fiber supplements can reduce the production of
chemicals which are produced by colon bacteria and normally excreted from the body by the
kidney, but build up in the body in patients on hemodialysis.
Stanford is currently not accepting patients for this trial.
For more information, please contact Timothy Meyer, 6508523314.