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Mary Leonard, MD, MSCE, is the Arline and Pete Harman Professor and Chair of the Department of Pediatrics at Stanford University School of Medicine and the Adalyn Jay Physician in Chief at Lucile Packard Children's Hospital Stanford. She assumed these positions on July 1, 2016.Energetic and collaborative, Dr. Leonard is a compassionate clinician and researcher who cares deeply about improving the health and well-being of children everywhere. A graduate of the Stanford University School of Medicine, Mary returned to Stanford Medicine in 2014 after spending 25 years at the Children’s Hospital of Philadelphia and the University of Pennsylvania. At Stanford, her multi-disciplinary research program is focused on the impact of chronic diseases on bone metabolism and nutrition across the life span. Mary directs the innovative and trans-disciplinary child and maternal health research and training initiatives of the Stanford Child Health Research Institute.Mary is a distinguished investigator, an expert clinician, and a respected mentor who embodies the academic and integrated mission of Stanford Medicine. A member of the Precision Health Committee, she is committed to Stanford Medicine’s vision of proactive and personalized health care and has been at the forefront of efforts to integrate Precision Health approaches and skills into our training programs.
My multidisciplinary research program is focused on (1) the detrimental effects of glucocorticoids, sarcopenia and inflammation on bone development in pediatric diseases, (2) the long-term effects of childhood cancer on bone and muscle quality, (3) the assessment of renal osteodystrophy using novel micro-imaging techniques, (4) the effects of vitamin D deficiency on physical function and cardiovascular disease, and (5) the evaluation of biomechanical interventions as anabolic bone therapies.
The Effect of Exercise on Muscle Dysfunction in Cystinosis
Classification of activity tolerance is of importance in chronic progressive myopathies, not
only to better understand functional implications of the disease state itself, but also for
purposes of exercise prescription for health maintenance. Maximal exercise testing has been
considered as the gold standard of assessing maximal aerobic capacity, however testing in
individuals with neuromuscular disease is often limited due to pain, activity intolerance,
musculoskeletal impairments, fatigue and other such related variables. Often, submaximal
exercise testing can overcome some of these obstacles, and as such, is used frequently in the
clinical environment. Non-ambulatory exercise testing utilizing an arm ergometer specifically
has not been studied as heavily, especially in those with progressive myopathies. For this
study, we will use maximal aerobic capacity testing for individuals with Cystinosis Myopathy
utilizing a bike ergometer to allow testing of individuals regardless of their ambulatory
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Bone Health in Pediatric Crohn's Disease: A Low Magnitude Mechanical Stimulus Trial
The purpose of this 12-month double blind, placebo controlled randomized trial is to evaluate
the effects of daily treatments with low magnitude mechanical stimuli on bone in 160 children
with Crohn disease.
Stanford is currently not accepting patients for this trial.
For more information, please contact Spectrum Child Health, 650-724-1175.