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clinical epidemiology, health services research, decision sciences, clinical trials in acute and chronic kidney disease
SARS-COV-2 Screening in Dialysis Facilities
Patients receiving dialysis are one of the highest risk groups for serious illness with
SARS-CoV-2 infection. In addition to the inherent risks of travel to and dialysis within
indoor facilities, patients receiving dialysis are more likely to be older, non-white, from
disadvantaged backgrounds, and have impaired immune responses to viral infections and
vaccinations. Universal testing offered at hemodialysis facilities could shield this
vulnerable population from exposure, enable early identification and treatment for those
affected, and reduce transmission to other patients and family members. In this pragmatic
cluster randomized controlled trial as part of NIH RADx-UP Consortium, we will randomize 62
US Renal Care facilities with an estimated 2480 patients to static versus dynamic universal
screening testing strategies. Static universal screening will involve offering patients
SARS-CoV-2 screening tests every two weeks; the dynamic universal screening strategy will
vary the frequency of testing from once every week to once every four weeks, depending on
community COVID-19 case rates. We hypothesize that patients dialyzing at facilities
randomized to a dynamic testing frequency responsive to community case rates will have higher
test acceptability (primary outcome), experience lower rates of COVID-19 death and
hospitalization, and report better experience-of-care metrics.
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Sit Less, Interact and Move More (SLIMM) 2 Study
- Prolonged sitting (sedentary behavior) is a risk factor for decreased kidney function,
obesity, diabetes and mortality. Prolonged sitting is associated with decreased kidney
function and increased risk of diabetes, heart disease and death.
- In a previous pilot study funded by NIH, it was shown that a Sit Less, Interact and Move
More (SLIMM) intervention targeting sedentary behavior in people with kidney disease was
able to decrease prolonged sitting but that effect was not sustained.
- Therefore, the researchers are currently conducting a follow-up study named Sit Less,
Interact and Move More (SLIMM) 2.
- This NIH funded study is conducted at the University of Utah and Stanford University.
- The purpose of this study is to see if guided resistance training (to improve muscle
strength) and semaglutide (FDA approved diabetes and weight loss medication that might
also improve physical function) can boost adherence to the SLIMM Intervention and reduce