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Clinical investigation has been a major component of my academic life for over 25 years. My research has focused on the epidemiology of ESRD and on clinical trials in acute and chronic kidney disease in children. As a pediatric nephrologist, I learned early the critical importance of collaborative research. I was the first pediatric nephrology representative to the NIH-NIDDK National CAPD Registry Advisory Committee in 1986 and served in a similar advisory role to the USRDS when it was established in 1988. I was a co-founder of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) in 1987 and continue to serve as Secretary of the NAPRTCS Board of Directors. The NAPRTCS is the largest and longest running multi-center study group in pediatric nephrology consisting of three registries (CKD, Dialysis, Transplant) that have enrolled over 17,000 patients from over 100 centers in four countries. My current participation in observational studies and clinical trials in pediatrics also includes the Prospective Pediatric CRRT Registry and the International Pediatric Peritonitis Registry. I now devote considerable time to mentoring junior faculty, fellows and other trainees. In 2006 I co-founded and continue to co-direct the Stanford Intensive Course in Clinical Research Study Design and Performance, a week-long immersion course for junior faculty and fellows that is given twice yearly. Since 2005 I have also been heavily involved in re-engineering the clinical and translational research enterprise at Stanford School of Medicine and now serve as Medical Director of Operations, Training and Compliance in Spectrum, Stanford’s Clinical and Translational Science Award.
Dialysis, kidney transplantation, continuous renal replacement therapy in pediatric patients; chronic kidney disease in pediatric patients.