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The Salzman lab is primarily a computational data science laboratory focused on studying RNA biology with a secondary focus on validation and novel experimental design to enable statistical analysis of RNA expression. We develop new data science methods to analyze the mechanism and function gene expression and RNA splicing. We design new methodology aiming to uncover how splicing is regulated at a single cell level and is dysregulated in diseases from viral infections to cancer. We have active work in the area of analysis of massive single-cell sequencing projects such as Tabula Sapiens, spatial genomics and analysis of host response to SARS-CoV-2.
Circular RNA regulation and function; computational and experimental approaches