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Our research group integrates new molecular technology development, advanced computation methods and genome biology to identify targets for therapy in cancer. We are pursuing projects focused on developing new therapies for stomach, bile duct and colon cancer. We also are involved in study the basis of genomic instability by examining chromosome structure.Ongoing projects include:1) Immunogenomic approaches to study cancer's interaction with the immune system and improve our understanding of immunotherapy2) Identification of kinase interactions which can improve targeted therapy strategies3) Use of advanced genome sequencing technologies including nanopore sequencers to understand the role of cancer rearrangements in response to therapy4) Identifying genes that increase the risk of developing cancer5) Developing new approaches for monitoring cancer from circulating DNAWe are developing new technologies for data storage using DNA technologies.
The Gastric Cancer Foundation: A Gastric Cancer Registry
The Gastric Cancer Registry will combine data acquired directly from patients with gastric
cancer; with a family history of gastric cancer in a first or second degree relative; or
persons with a known germline mutation in their CDH1 (E-Cadherin) gene via an online
questionnaire with genomic data obtained from saliva, blood and tissue samples. The purpose
of this registry is to gain better understanding of the causes of gastric cancer, both
environmental and genetic; whether certain genomic data can predict outcomes of treatment and
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Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
Our research of the biology of upper gastrointestinal cancers involves the study of tissue
samples and cells from biopsies of persons with gastric or esophageal cancer or blood samples
from upper gastrointestinal cancer patients and persons at high inherited risk for these
cancers. We hope to learn the role genes and proteins play in the development of gastric and