Brice Gaudilliere

Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult-MSD) and, by courtesy, of Pediatrics (Neonatology)

Bio

Born in France, Dr. Gaudilliere studied Engineering at Ecole Polytechnique before completing an MD-PhD degree from the Harvard-MIT Health Sciences and Technology program and a postdoctoral fellowship at Stanford University (Dr. Garry Nolan laboratory). Research in the Gaudilliere lab combines high parameter mass cytometry (suspension and imaging mass cytometry) with other proteomics approaches to study how the human immune system responds and adapts to physiological or pathological stressors. Ongoing studies focus on several clinical scenarios including, 1) immune mechanisms of surgical recovery and complications (NIGMSR35), 2) pregnancy and preterm birth (NICHDP01, DDCF, BMGF, ITI, MOD), 3) immune dysfunction and outcomes prediction in patients with COVID19 (Fast Grant, CEND award).

Dr. Gaudilliere is a Board-Certified Anesthesiologist and works clinically in the operating room 25% of his time.

Clinical Focus

Anesthesia

Academic Appointments

Associate Professor - University Medical Line, Anesthesiology, Perioperative and Pain Medicine
Associate Professor - University Medical Line (By courtesy), Pediatrics - Neonatal and Developmental Medicine
Member, Maternal & Child Health Research Institute (MCHRI)
Member, Wu Tsai Neurosciences Institute

Honors & Awards

Promise in biomedical research, Doris Duke Charitable Foundation (2017)
Kozaka research award, International Anesthesia Research Society (2013)
Stanford Society for Physician Scholar's award, SSPS (2011, 2012)
Albert J. Ryan Fellowship, Harvard Medical School (2004)
Carnot Foundation Scholarship, Ecole Polytechnique, Paris, France (2000)
George Lurcy's Fellowship, Harvard University (2000)

Professional Education

BS, Ecole Polytechnique, Engineering (2000)
PhD, Harvard Medical School, Neurobiology (2005)
Medical Education: Harvard Medical School (2009) MA
Residency: Stanford University Anesthesiology Residency (2013) CA
Board Certification: American Board of Anesthesiology, Anesthesia (2014)

Patents

Brice Gaudilliere, Gabriela Fragiadakis, Martin Angst, Garry Nolan. "United States Patent S13-373 Flow cytometry methods for the diagnosis of prolonged convalescence after traumatic injury", Leland Stanford Junior University
Azad Bonni, Aryaman Shalizi, Brice Gaudilliere. "United StatesMethods and compositions for modulating synapse formation", Harvard University

Contact

Academic gbrice@stanford.edu

Clinical Anesthesia Department 300 Pasteur Dr Rm S238 Grant Bldg Stanford CA 94305 Tel: (650) 723-6412 Fax: (650) 725-8544

Current Research and Scholarly Interests

The advent of high dimensional flow cytometry has revolutionized our ability to study and visualize the human immune system. Our group combines high parameter mass cytometry (a.k.a Cytometry by Time of Flight Mass Spectrometry, CyTOF), with advanced bio-computational methods to study how the human immune system responds and adapts to acute physiological perturbations. The laboratory currently focuses on two clinical scenarios: surgical trauma and pregnancy.

Deep immune profiling of patients undergoing and recovering from surgery: Using high dimensional mass cytometry, we have recently shown that the signaling behavior of specific innate immune cells measured before surgery in patients blood was strongly associated with surgical recovery. Prospective validation of reported immune correlates of surgical recovery are underway. Ongoing work in humans and animal models focuses on the mechanisms by which pre-operative habilitation interventions may alter a patient’s immune state to improve recovery after surgery.

Deep Immune profiling of normal and preterm pregnancy: Our group is an integral component of a multi-disciplinary effort aiming at understanding the mechanisms of preterm birth, and identifying predictive factors of premature delivery. We have now developed a pipeline and the analytical framework to integrate the single-cell analysis of immune signaling networks by mass cytometry and proteomic profiling of secreted serum factors with the precise phenotyping of pregnancy-related clinical outcomes. In a pilot cross-sectional study of non-pregnant women, we identified candidate immune signatures that differentiated women with a history of preterm or term pregnancies. Longitudinal studies in pregnant patients are ongoing to validate these findings.

Clinical Trials

Immune Modulation by Enhanced vs Standard Prehabilitation Program Before Major Surgery Recruiting
More
Over 30 million surgeries are performed annually in the US. Up to 30% of surgical patients experience delayed surgical recovery, marked by prolonged post-surgical pain, opioid consumption, and functional impairment, which contributes $8 billion annually to US health care costs. Novel interventions that improve the resolution of pain, minimize opioid exposure, and accelerate functional recovery after surgery are urgently needed. Multi-modal pre-operative optimization programs (or "prehab") integrating exercise, nutrition, and stress reduction have been shown to safely and effectively improve outcomes after surgery. However, no objective biological markers assess prehab effectiveness and are able to tailor prehab programs to individual patients. Surgery is a profound immunological perturbation, during which a complex network of innate and adaptive immune cells is mobilized to organize the recovery process of wound healing, tissue repair, and pain resolution. As such, the in-depth assessment of a patient's immune system before surgery is a promising approach to tailor prehab programs to modifiable biological markers associated with surgical recovery. The primary goal of this clinical trial is to determine the effect of a personalized prehab program on patients immunological status before surgery.

Lead Sponsor
- Stanford University
Stanford Investigators
View full details
Detection of Immune Changes as a Result of Surgical Trauma in Human Subject Recruiting
More
Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study to characterize the cellular and molecular mechanisms immune response to surgical trauma. Additionally, detailed information about patients' recovery profile will be recorded over a period of 6 weeks, with the eventual goal of linking immune responses to recovery profiles.
Lead Sponsor
Stanford Investigators
- Martin S. Angst
- Brice Gaudilliere
View full details
Immune-modulation Effects of an Arginine Rich Nutritional Supplement in Surgical Patients Not Recruiting
More
The primary objective of this study is to characterize the immune-modulatory effects of arginine-rich nutritional supplements in patients undergoing surgery. Numerical and functional changes of all circulating immune cells will be assessed with mass cytometry.

Stanford is currently not accepting patients for this trial. For more information, please contact Julian Silva, MA, 650-724-9341.
Lead Sponsor
Stanford Investigators
- Martin S. Angst
- Brice Gaudilliere
View full details

2021-22 Courses

Independent Studies
- Graduate Research
  ANES 399 (Sum)
- Medical Scholars Research
  ANES 370 (Sum)
- Undergraduate Research
  ANES 199 (Sum)

Stanford Advisees

Orals Chair
Larry Kalesinskas
Postdoctoral Faculty Sponsor
Jakob Einhaus, Dorien Feyaerts, Masaki Sato
Postdoctoral Research Mentor
Dorien Feyaerts

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