FEATURED PUBLICATIONS

 

Recent Publications (2018-present)

  1. Fan Yang, Duo Zhang, Haowen Jiang, Jiangbin Ye, Lin Zhang, Stephen J Bagley, Jeffery Winkler, Yanqing Gong, Yi Fan. Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Science Translational Medicine 15 Feb 2023 Vol 15, Issue 683 DOI: 10.1126/scitranslmed.abq3558.  
  2. Duo Zhang, Albert Li, Menggui Huang, Lin Zhang, Kathryn Wellen, Xiaowei Xu, Crystal Conn, Wei Zou, Mark Kahn, Seth Rhoades, Aalim Weljie, Nduka Amankulor, Daniel Yoshor, Jiangbin Ye, Constantinos Koumenis, Yanqing Gong, Yi Fan. PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Cell Metabolism. 2023 Feb 16;S1550-4131(23)00010-4. doi: 10.1016/j.cmet.2023.01.010.
  3. Pingting Liu, Wei Chen, Haowen Jiang*, Haoliang Huang, Liping Liu, Fang Fang, Liang Li, Xue Feng, Dong Liu, Roopa Dalal, Yang Sun, Paymaan Jafar-Nejad, Karen Ling, Frank Rigo, Jiangbin Ye, Yang Hu. Differential Effects of SARM1 Inhibition in Traumatic Glaucoma and EAE Optic Neuropathies. Molecular Therapy-Nucleic Acids. February 26, 2023 DOI:https://doi.org/10.1016/j.omtn.2023.02.029. *co-first author.
  4. Haowen Jiang, Albert M. Li, Jiangbin Ye. The magic bullet: Niclosamide. Frontiers Onology. Nov 21;12:1004978. doi: 10.3389/fonc.2022.1004978. eCollection 2022.PMID: 36479072
  5. Haowen Jiang, Rachel Greathouse, Sarah J. Tiche, Man Zhao, Bo He, Yang Li, Albert M. Li, Balint Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Meng-Ning Zhou, Joshua J. Gruber, Erinn B. Rankin, Zhen Hu, Hiroyuki Shimada, Bill Chiu, Jiangbin Ye. Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma. Cancer Research. 2022.
  6. Ioannis I Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V Karagounis, Brett I Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S Wu, Yang Li, Jiangbin Ye, David A Scott, Andrei L Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W Tobias, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G Hatzigeorgiou, Sandra Ryeom, J Alan Diehl, Serge Y Fuchs, Ellen Puré, Constantinos Koumenis. A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression. Nature cell biology. 24, pages940–953 (2022). 
  7. Vignesh Viswanathan, Hongbin Cao, Julie Saiki, Dadi Jiang, Aaron Mattingly, Dhanya Nambiar, Joshua Bloomstein, Yang Li, Sizun Jiang, Manish Chamoli, Davud Sirjani, Michael Kaplan, F Christopher Holsinger, Rachel Liang, Rie Von Eyben, Haowen Jiang, Li Guan, Edward Lagory, Zhiping Feng, Garry Nolan, Jiangbin Ye, Nicholas Denko, Sarah Knox, Daria-Mochly Rosen, Quynh-Thu Le. Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype. PNAS nexus. Volume 1, Issue 2, May 2022, pgac056. 
  8. Sooyeon Lee, Haixia Xu, Aidan Van Vleck, Alex M. Mawla, Albert Mao Li, Jiangbin Ye, Mark O. Huising, Justin P. Annes. β-cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes. Diabetes. 2022 Apr 26;db210834. doi: 10.2337/db21-0834 
  9. Gentaro Ikeda, Michelle R. Santoso, Yuko Tada, Albert M. Li, Evgeniya Vaskova, Ji-Hye Jung, Connor O’Brien, Elizabeth Egan, Jiangbin Ye, and Phillip C. Yang. Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium. Journal of American College of Cardiology. 2021 Mar;77(8) 1073-1088. PMID: 33632482. 
  10. Fang F, Zhuang P, Feng X, Liu P, Liu D, Huang H, Li L, Chen W, Liu L, Sun Y, Jiang H, Ye J, Hu Y. NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function. Mol Ther. 2022 Jan 31:S1525-0016(22)00074-0. doi: 10.1016/j.ymthe.2022.01.035. Online ahead of print. PMID: 35114390
  11. Haowen Jiang, Rachel L Greathouse, Bo He, Yang Li, Albert M. Li, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Mengning Zhou, Joshua J. Gruber, Hiroyuki Shimada, Bill Chiu, Jiangbin Ye. Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler. bioRxiv 2021.09.05. doi: https://doi.org/10.1101/2021.09.05.459035 
  12. Albert M. Li, Yang Li, Bo He, Haowen Jiang, Yaniel Ramirez, Meng-Ning Zhou, Chao Lu, Joshua J. Gruber, Erinn B. Rankin, Jiangbin Ye. Serine starvation silences estrogen receptor signaling through histone hypoacetylation. bioRxiv 2021.09.05. doi: https://doi.org/10.1101/2021.09.05.459037
  13. Dhanir Tailor, Catherine C. Going, Angel Resendez, Vineet Kumar, Dhanya K. Nambiar, Yang Li, Arpit Dheeraj, Edward Lewis LaGory, Ali Ghoochani, Alisha M. Birk, Tanya Stoyanova, Jiangbin Ye, Amato J. Giaccia, Quynh-Thu Le, Rana P. Singh, George W. Sledge, Sharon J. Pitteri, Sanjay V. Malhotra. Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer. Br J Cancer (2020) Nov 3. DOI: 10.1038/s41416-020-01137-4. PMID 33139797.
  14. Liz J. Valente, Amy Tarangelo, Albert Mao Li, Marwan Naciri, Nitin Raj, Anthony M. Boutelle, Yang Li, Stephano Spano Mello, Kathryn Bieging-Rolett, Ralph J. DeBerardinis, Jiangbin Ye, Scott J. Dixon, Laura D. Attardi. p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen. J Cell Biol (2020) 219 (11): e201908212.DOI: 10.1083.
  15. Yiren Xiao, Kaushik N Thakkar, Hongjuan Zhao, James Broughton, Yang Li, Jose A Seoane, Anh N Diep, Thomas J Metzner, Rie von Eyben, David L Dill, James D Brooks, Christina Curtis, John T Leppert, Jiangbin Ye, Donna M Peehl, Amato J Giaccia, Subarna Sinha, Erinn B Rankin. The m 6 A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. PNAS 2020 Aug 19 DOI: 10.1073/pnas.200516117. PMID: 32817424
  16. Albert M. Li and Jiangbin Ye. Reprogramming of serine, glycine and one-carbon metabolism in cancer. Biochimica et biophysica acta. Molecular basis of disease. 2020 May DOI: 10.1016/j.bbadis.2020.1655841
  17. Albert M. Li and Jiangbin Ye. The PHGDH enigma: do cancer cells only need serine or also a redox modulator? Cancer Letters 2020 Feb 4 DOI: 10.1016/j.canlet2020.01.036. PMID: 32032680.
  18. Yang Li, Joshua J. Gruber, Ulrike M. Litzenburger, Yiren Zhou, Yu Rebecca Miao, Edward L. LaGory, Albert M. Li, Zhen Hu, Lori S. Hart, John M. Maris, Howard Y. Chang, Amato J. Giaccia, Jiangbin Ye. Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia.  Cell Death & Disease 2020 Feb 6;11(2):102 DOI: 10.1038/s41419-020-2303-9 PMCID: PMC7005271.
  19. Albert M. Li, Gregory S. Ducker, Yang Li, Jose A. Seoane, Yiren Xiao, Stavros Melemenidis, Yiren Zhou, Ling Liu, Sakari Vanharanta, Edward E. Graves, Erinn B. Rankin, Christina Curtis, Joan Massagué, Joshua D. Rabinowitz, Craig B. Thompson*, Jiangbin Ye*.  Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Molecular Cancer Research 2020 Jan 15 DOI: 10.1158/1541-7786.MCR-19-0606. PMID: 31941752 *Co-corresponding author.
  20. Feven Tameire, Ioannis I. Verginadis, Nektaria Maria Leli, Christine Polte, Crystal S. Conn , Rani Ojha, Carlo Salas Salinas, Frank Chinga, Alexandra. M. Monroy, Weixuan Fu , Paul Wang , Andrew Kossenkov, Jiangbin Ye, Ravi K. Amaravadi, Zoya Ignatova, Serge Y. Fuchs, J. Alan Diehl , Davide Ruggero and Constantinos Koumenis . ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature Cell Biology. volume 21, pages 889–899 (2019) PMCID: PMC6608727.
  21. Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, and Scott J. Dixon. P53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Reports. 2018 January 16;22(3):569-575.

 

 

Previous Publications 

 

  1. Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis and Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes & Development 2015. 29:2331-2336.
  2. Jiangbin Ye, Jing Fan, Sriram Venneti, Ying-Wooi Wan, Bruce R. Pawel, Ji Zhang, Lydia W.S. Finley, Chao Lu, Tullia Lindsten, Justin Cross, Guoliang Qing, Zhandong Liu, M. Celeste Simon, Joshua D. Rabinowitz, and Craig B. Thompson. Serine catabolism regulates mitochondrial redox control during hypoxia.  Cancer Discovery. 2014 Sep 3. pii: CD-14-0250. 
  3. Jing Fan, Jiangbin Ye, Jurre J. Kamphorst, Tomer Shlomi, Craig B. Thompson, and Joshua D. Rabinowitz.  Quantitative flux analysis reveals folate-dependent NADPH production. Nature 2014 Jun 12;510(7504):298-302.
  4. Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S. Ward, Jing Fan, Joshua D. Rabinowitz and Craig B. Thompson. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. PNAS 2012 May 1;109(18):6904-9
  5.  Ye, J., Kumanova, M., Hart, L.S., Sloane, K., Zhang, H., De Panis, D.N., Bobrovnikova-Marjon, Diehl, J.A., Ron, D., Koumenis, C. The GCN2-ATF4 pathway is critical for tumor cell survival and proliferation in response to nutrient deprivation. EMBO Journal. 2010;29(12):2082-2096

 

For a complete list of publications, please click here