The Laboratory of Dr. Thomas Südhof
Investigating the formation of synapses and synaptic communication
For a person to think, act, or feel, the neurons in a person’s brain must communicate continuously, rapidly, and repeatedly. This communication occurs at synapses, specialized junctions that allow neurons to exchange information on a millisecond timescale and that organize neurons in vast overlapping circuits.
When stimulated, a presynaptic neuron releases a chemical neurotransmitter signal that diffuses across the synaptic cleft to react with postsynaptic receptor neurons or muscle cells.
Thomas Südhof’s laboratory studies how synapses form in the brain, how their properties are specified, and how they accomplish the rapid and precise signaling that forms the basis for all information processing by the brain.