Bio

Clinical Focus


  • Pediatric Infectious Disease

Academic Appointments


Honors & Awards


  • Outstanding Faculty Educator Award, University of Minnesota (2006)
  • Outstanding Faculty Educator Award, University of Minnesota (2004)
  • Pediatric Housestaff Outstanding Fellow's Award, Stanford University (2003)
  • Member, Alpha Omega Alpha (1999)

Professional Education


  • Board Certification: Pediatrics, American Board of Pediatrics (1999)
  • Masters of Science, Univ Minnesota Schl Public Hlth, Clinical Research (2006)
  • Fellowship:Stanford University Medical Center (2003) CA
  • Residency:University of Rochester (1999) NY
  • Medical Education:Baylor College of Medicine (1996) TX
  • Bachelor of Arts, University of Texas at Austin, Biology (1992)
  • Board Certification: Pediatric Infectious Disease, American Board of Pediatrics (2005)

Research & Scholarship

Current Research and Scholarly Interests


My research interest is focused on Herpes virus pathogenesis and the host immune response to these viral infections. To characterize these interactions, we use flow-cytometry based immunology assays, culture-based assays, molecular techniques and tissue histology. My current study investigates anti-viral immunity to CMV in lung transplant patients to characterize the kinetics of CMV-specific T-cell reconstitution and to test its ability to predict CMV infection and allograft rejection.

Publications

Journal Articles


  • Human Parvovirus B19 in Solid Organ Transplantation AMERICAN JOURNAL OF TRANSPLANTATION Eid, A. J., Chen, S. F. 2013; 13: 201-205

    View details for DOI 10.1111/ajt.12111

    View details for Web of Science ID 000315907900021

    View details for PubMedID 23465012

  • Conversion From Tacrolimus/Mycophenolic Acid to Tacrolimus/Leflunomide to Treat Cutaneous Warts in a Series of Four Pediatric Renal Allograft Recipients TRANSPLANTATION Lieuko Nguyen, L., McClellan, R. B., Chaudhuri, A., Alexander, S. R., Chen, S. F., Concepcion, W., Grimm, P. 2012; 94 (5): 450-455

    Abstract

    The challenge of immunosuppression in pediatric renal transplantation is to balance preventing rejection while avoiding infectious complications. A dermatological complication of immunosuppression is viral warts, which cause significant disfigurement and increase the risk of skin malignancy.We present three pediatric and adolescent renal allograft recipients with multiple, recalcitrant verrucae vulgares lesions and one patient with molluscum contagiosum who were switched from mycophenolate mofetil to leflunomide. Teriflunomide metabolite levels were carefully maintained between 50,000 and 100,000 ng/mL to balance its immunosuppressive and antiviral properties. No adverse events requiring discontinuation of leflunomide were encountered.Switching from mycophenolate mofetil to leflunomide successfully cleared verrucae vulgares and molluscum lesions in all four renal transplant patients.The ability to minimize and even resolve warts can improve quality of life by reducing risk of skin malignancies and emotional distress in solid organ transplant patients. Leflunomide is a potential therapeutic option for posttransplantation patients with skin warts because it serves both as an adjunct to the immunosuppressive regimen and an antiviral agent.

    View details for DOI 10.1097/TP.0b013e318264351e

    View details for Web of Science ID 000308668000012

    View details for PubMedID 22960763

  • Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood JOURNAL OF INFECTIOUS DISEASES Chen, S. F., Tu, W. W., Sharp, M. A., Tongson, E. C., He, X. S., Greenberg, H. B., Holmes, T. H., Wang, Z. T., Kemble, G., Manganello, A. M., Adler, S. P., Dekker, C. L., Levvis, D. B., Arvin, A. M. 2004; 189 (9): 1619-1627

    Abstract

    Human cytomegalovirus (CMV) establishes persistent infection, with control of replication thought to be mediated by CMV-specific CD8 T cells. Primary CMV infection commonly affects young children and causes prolonged viral shedding in saliva and urine. We investigated whether this virus-host interaction pattern reflects a developmental deficiency of antiviral CD8 T cell-mediated immunity during childhood. CMV-specific CD8 T cell responses in asymptomatic children with active infection were not different from adults with recent or long-term infection in frequency and functional analyses. High urine CMV concentrations were detected, despite these CMV-specific CD8 T cell responses. We conclude that delayed resolution of primary CMV infection in young children is not caused by a deficient CMV-specific CD8 T cell response. Because these healthy children continue to have local CMV replication, we suggest that CD8 T cells may function primarily to prevent symptomatic, disseminated disease.

    View details for Web of Science ID 000220951300010

    View details for PubMedID 15116298

  • Persistent and selective deficiency of CD4(+) T cell immunity to cytomegalovirus in immunocompetent young children JOURNAL OF IMMUNOLOGY Tu, W. W., Chen, S., Sharp, M., Dekker, C., Manganello, A. M., Tongson, E. C., Maecker, H. T., Holmes, T. H., Wang, Z. T., Kemble, G., Adler, S., Arvin, A., Lewis, D. B. 2004; 172 (5): 3260-3267

    Abstract

    Healthy young children who acquire CMV have prolonged viral shedding into the urine and saliva, but whether this is attributable to limitations in viral-specific immune responses has not been explored. In this study, we found that otherwise immunocompetent young children after recent primary CMV infection accumulated markedly fewer CMV-specific CD4(+) T cells that produced IFN-gamma than did adults. These differences in CD4(+) T cell function persisted for more than 1 year after viral acquisition, and did not apply to CMV-specific IFN-gamma production by CD8(+) T cells. The IFN-gamma-producing CD4(+) T cells of children or adults that were reactive with CMV Ags were mainly the CCR7(low) cell subset of memory (CD45R0(high)CD45RA(low)) cells. The decreased IFN-gamma response to CMV in children was selective, because their CCR7(low) memory CD4(+) T cells and those of adults produced similar levels of this cytokine after stimulation with staphylococcal enterotoxin B superantigen. CD4(+) T cells from children also had reduced CMV-specific IL-2 and CD154 (CD40 ligand) expression, suggesting an early blockade in the differentiation of viral-specific CD4(+) T cells. Following CMV acquisition, children, but not adults, persistently shed virus in urine, and this was observable for at least 29 mo postinfection. Thus, CD4(+) T cell-mediated immunity to CMV in humans is generated in an age-dependent manner, and may have a substantial role in controlling renal viral replication and urinary shedding.

    View details for Web of Science ID 000189186000069

    View details for PubMedID 14978134

  • Mycobacterium bovis disease in a pediatric renal transplant patient PEDIATRIC INFECTIOUS DISEASE JOURNAL Chen, S. F., Gutierrez, K. 2006; 25 (6): 564-566

    Abstract

    We describe a pediatric renal transplant patient with Mycobacterium bovis disease who was successfully treated using an antituberculosis regimen that included rifampin. We discuss the history of M. bovis and the diagnosis and management of M. bovis infection in renal transplant patients.

    View details for DOI 10.1097/01.inf.0000219482.75490.d5

    View details for Web of Science ID 000238432300020

    View details for PubMedID 16732161

  • Staphylococcus aureus decolonization PEDIATRIC INFECTIOUS DISEASE JOURNAL Chen, S. F. 2005; 24 (1): 79-80
  • Acute retinal necrosis syndrome in a child PEDIATRIC INFECTIOUS DISEASE JOURNAL Chen, S., Weinberg, G. A. 2002; 21 (1): 78-80

    Abstract

    We recently cared for an 11-year-old child with acute retinal necrosis syndrome, an ophthalmologic condition characterized by the triad of anterior uveitis, occlusive retinal vasculitis and progressive peripheral retinal necrosis. Acute retinal necrosis syndrome occurs primarily in nonimmunocompromised adults as a result of reactivated herpes simplex or varicella-zoster virus infection. Antiviral and antiinflammatory therapy appears to reduce the incidence of vision-threatening retinal necrosis and involvement of the contralateral eye.

    View details for Web of Science ID 000173306400020

    View details for PubMedID 11791109

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