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  • Set-shifting among adolescents with anorexia nervosa INTERNATIONAL JOURNAL OF EATING DISORDERS Fitzpatrick, K. K., Darcy, A., Colborn, D., Gudorf, C., Lock, J. 2012; 45 (7): 909-912

    Abstract

    Set-shifting difficulties are documented for adults with anorexia nervosa (AN). However, AN typically onsets in adolescents and it is unclear if set-shifting difficulties are a result of chronic AN or present earlier in its course. This study examined whether adolescents with short duration AN demonstrated set-shifting difficulties compared to healthy controls (HC).Data on set-shifting collected from the Delis-Kaplan executive functioning system and Wisconsin card sort task (WCST) as well as eating psychopathology were collected from 32 adolescent inpatients with AN and compared with those from 22 HCs.There were no differences in set-shifting in adolescents with AN compared to HCs on most measures.The findings suggest that set-shifting difficulties in AN may be a consequence of AN. Future studies should explore set-shifting difficulties in a larger sample of adolescents with the AN to determine if there is sub-set of adolescents with these difficulties and determine any relationship of set-shifting to the development of a chronic from of AN.

    View details for DOI 10.1002/eat.22027

    View details for Web of Science ID 000310271600014

    View details for PubMedID 22692985

  • Set-Shifting Among Adolescents With Bulimic Spectrum Eating Disorders PSYCHOSOMATIC MEDICINE Darcy, A. M., Fitzpatrick, K. K., Colborn, D., Manasse, S., Datta, N., Aspen, V., Shields, C. S., Le Grange, D., Lock, J. 2012; 74 (8): 869-872

    Abstract

    Set-shifting difficulties are observed among adults with bulimia nervosa (BN). This study aimed to assess whether adolescents with BN and BN spectrum eating disorders exhibit set-shifting problems relative to healthy controls.Neurocognitive data from 23 adolescents with BN were compared with those from 31 adolescents with BN-type eating disorder not otherwise specified and 22 healthy controls on various measures of set-shifting (Trail Making Task [shift task], Color-Word Interference, Wisconsin Card Sorting Test, and Brixton Spatial Anticipation Task).No significant differences in set-shifting tasks were found among groups (p >.35), and effect sizes were small (Cohen f < 0.17).Cognitive inflexibility may develop over time because of the eating disorder, although it is possible that there is a subset of individuals in whom early neurocognitive difficulty may result in a longer illness trajectory. Future research should investigate the existence of neurocognitive taxons in larger samples and use longitudinal designs to fully explore biomarkers and illness effects.clinicaltrials.gov NCT00879151.

    View details for DOI 10.1097/PSY.0b013e31826af636

    View details for Web of Science ID 000310047800011

    View details for PubMedID 23001391

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