Disease Research Area 2 (Lung Transplantation)
Loss of the functional airway microvasculature predisposes lung transplants to chronic rejection. We investigate mechanisms associated with transplant microvascular injury as well as repair. We are interested in developing novel therapeutics to improve airway anastomosis health and long-term survival of lung transplants. Our discoveries in airway microvascular biology may also provide insights into other chronic lung diseases such as emphysema and pulmonary hypertension.
"Lung transplantation is a cure for thousands of patients with advanced lung disease. Our group focuses on how airway microvascular injury contributes to harmful airway disease and what steps might be taken to protect the transplant to optimize the life of the patient."
- Mark Nicolls, MD.