“Our lab focus is on how vascular inflammation contributes to lung and lymphatic disease and to develop targeted therapeutics that can safely treat these conditions.” - Mark Nicolls

Research Areas


Our group investigates the so-called 'third circulation', the lymphatics. 

Learn More About Lymphedema >>


Our group recently found that loss of endothelial cell (EC) hypoxia inducible factor-2α (HIF-2α), induced by cigarette smoke, plays a key role in the development of emphysema.

Learn More About Emphysema/COPD >>


Lung Transplantation

Loss of the functional airway microvasculature predisposes lung transplants to chronic rejection. 

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Pulmonary Hypertension

Pulmonary Hypertension is a deadly disease, currently without a cure.

Learn More About Pulmonary Hypertension >>